These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

728 related articles for article (PubMed ID: 22396593)

  • 1. Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
    Neff T; Sinha AU; Kluk MJ; Zhu N; Khattab MH; Stein L; Xie H; Orkin SH; Armstrong SA
    Proc Natl Acad Sci U S A; 2012 Mar; 109(13):5028-33. PubMed ID: 22396593
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
    Danis E; Yamauchi T; Echanique K; Haladyna J; Kalkur R; Riedel S; Zhu N; Xie H; Bernt KM; Orkin SH; Armstrong SA; Neff T
    Exp Hematol; 2015 Nov; 43(11):930-935.e6. PubMed ID: 26118502
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.
    Fiskus W; Pranpat M; Balasis M; Herger B; Rao R; Chinnaiyan A; Atadja P; Bhalla K
    Mol Cancer Ther; 2006 Dec; 5(12):3096-104. PubMed ID: 17172412
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Polycomb repressive complex 2 regulates normal development of the mouse heart.
    He A; Ma Q; Cao J; von Gise A; Zhou P; Xie H; Zhang B; Hsing M; Christodoulou DC; Cahan P; Daley GQ; Kong SW; Orkin SH; Seidman CE; Seidman JG; Pu WT
    Circ Res; 2012 Feb; 110(3):406-15. PubMed ID: 22158708
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.
    Thiel AT; Feng Z; Pant DK; Chodosh LA; Hua X
    Haematologica; 2013 Jun; 98(6):918-27. PubMed ID: 23349306
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.
    Aoki R; Chiba T; Miyagi S; Negishi M; Konuma T; Taniguchi H; Ogawa M; Yokosuka O; Iwama A
    J Hepatol; 2010 Jun; 52(6):854-63. PubMed ID: 20395008
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.
    Shi J; Wang E; Zuber J; Rappaport A; Taylor M; Johns C; Lowe SW; Vakoc CR
    Oncogene; 2013 Feb; 32(7):930-8. PubMed ID: 22469984
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation.
    Rush M; Appanah R; Lee S; Lam LL; Goyal P; Lorincz MC
    Epigenetics; 2009 Aug; 4(6):404-14. PubMed ID: 19717977
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
    Xu B; On DM; Ma A; Parton T; Konze KD; Pattenden SG; Allison DF; Cai L; Rockowitz S; Liu S; Liu Y; Li F; Vedadi M; Frye SV; Garcia BA; Zheng D; Jin J; Wang GG
    Blood; 2015 Jan; 125(2):346-57. PubMed ID: 25395428
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.
    Mochizuki-Kashio M; Mishima Y; Miyagi S; Negishi M; Saraya A; Konuma T; Shinga J; Koseki H; Iwama A
    Blood; 2011 Dec; 118(25):6553-61. PubMed ID: 22042701
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
    Agherbi H; Gaussmann-Wenger A; Verthuy C; Chasson L; Serrano M; Djabali M
    PLoS One; 2009 May; 4(5):e5622. PubMed ID: 19462008
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
    Kirmizis A; Bartley SM; Kuzmichev A; Margueron R; Reinberg D; Green R; Farnham PJ
    Genes Dev; 2004 Jul; 18(13):1592-605. PubMed ID: 15231737
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Loss of BAP1 function leads to EZH2-dependent transformation.
    LaFave LM; Béguelin W; Koche R; Teater M; Spitzer B; Chramiec A; Papalexi E; Keller MD; Hricik T; Konstantinoff K; Micol JB; Durham B; Knutson SK; Campbell JE; Blum G; Shi X; Doud EH; Krivtsov AV; Chung YR; Khodos I; de Stanchina E; Ouerfelli O; Adusumilli PS; Thomas PM; Kelleher NL; Luo M; Keilhack H; Abdel-Wahab O; Melnick A; Armstrong SA; Levine RL
    Nat Med; 2015 Nov; 21(11):1344-9. PubMed ID: 26437366
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.
    Zhou J; Bi C; Cheong LL; Mahara S; Liu SC; Tay KG; Koh TL; Yu Q; Chng WJ
    Blood; 2011 Sep; 118(10):2830-9. PubMed ID: 21734239
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
    Kim W; Bird GH; Neff T; Guo G; Kerenyi MA; Walensky LD; Orkin SH
    Nat Chem Biol; 2013 Oct; 9(10):643-50. PubMed ID: 23974116
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML.
    Paul TA; Bies J; Small D; Wolff L
    Blood; 2010 Apr; 115(15):3098-108. PubMed ID: 20190193
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
    Ntziachristos P; Tsirigos A; Van Vlierberghe P; Nedjic J; Trimarchi T; Flaherty MS; Ferres-Marco D; da Ros V; Tang Z; Siegle J; Asp P; Hadler M; Rigo I; De Keersmaecker K; Patel J; Huynh T; Utro F; Poglio S; Samon JB; Paietta E; Racevskis J; Rowe JM; Rabadan R; Levine RL; Brown S; Pflumio F; Dominguez M; Ferrando A; Aifantis I
    Nat Med; 2012 Feb; 18(2):298-301. PubMed ID: 22237151
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.
    Berezovska OP; Glinskii AB; Yang Z; Li XM; Hoffman RM; Glinsky GV
    Cell Cycle; 2006 Aug; 5(16):1886-901. PubMed ID: 16963837
    [TBL] [Abstract][Full Text] [Related]  

  • 19. High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid.
    Lee ER; Murdoch FE; Fritsch MK
    Stem Cells; 2007 Sep; 25(9):2191-9. PubMed ID: 17525233
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
    Kong X; Chen L; Jiao L; Jiang X; Lian F; Lu J; Zhu K; Du D; Liu J; Ding H; Zhang N; Shen J; Zheng M; Chen K; Liu X; Jiang H; Luo C
    J Med Chem; 2014 Nov; 57(22):9512-21. PubMed ID: 25369470
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 37.