192 related articles for article (PubMed ID: 22403294)
1. A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.
Bhaskar V; Goldfine ID; Bedinger DH; Lau A; Kuan HF; Gross LM; Handa M; Maddux BA; Watson SR; Zhu S; Narasimha AJ; Levy R; Webster L; Wijesuriya SD; Liu N; Wu X; Chemla-Vogel D; Tran C; Lee SR; Wong S; Wilcock D; White ML; Corbin JA
Diabetes; 2012 May; 61(5):1263-71. PubMed ID: 22403294
[TBL] [Abstract][Full Text] [Related]
2. Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.
Corbin JA; Bhaskar V; Goldfine ID; Bedinger DH; Lau A; Michelson K; Gross LM; Maddux BA; Kuan HF; Tran C; Lao L; Handa M; Watson SR; Narasimha AJ; Zhu S; Levy R; Webster L; Wijesuriya SD; Liu N; Wu X; Chemla-Vogel D; Lee SR; Wong S; Wilcock D; White ML
PLoS One; 2014; 9(2):e88684. PubMed ID: 24533136
[TBL] [Abstract][Full Text] [Related]
3. Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody.
Bedinger DH; Goldfine ID; Corbin JA; Roell MK; Adams SH
J Pharmacol Exp Ther; 2015 Apr; 353(1):35-43. PubMed ID: 25613982
[TBL] [Abstract][Full Text] [Related]
4. XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity.
Bhaskar V; Lau A; Goldfine ID; Narasimha AJ; Gross LM; Wong S; Cheung B; White ML; Corbin JA
Diabetes Obes Metab; 2013 Mar; 15(3):272-5. PubMed ID: 23039274
[TBL] [Abstract][Full Text] [Related]
5. Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.
Bedinger DH; Kieffer DA; Goldfine ID; Roell MK; Adams SH
J Cell Biochem; 2015 Sep; 116(9):2109-19. PubMed ID: 25808283
[TBL] [Abstract][Full Text] [Related]
6. Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.
Issafras H; Bedinger DH; Corbin JA; Goldfine ID; Bhaskar V; White ML; Rubin P; Scannon PJ
J Diabetes Sci Technol; 2014 Jul; 8(4):865-73. PubMed ID: 24876415
[TBL] [Abstract][Full Text] [Related]
7. A Novel Allosteric Insulin Receptor-Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys.
Bezwada P; Zhao J; Der K; Shimizu B; Cao L; Ahene A; Rubin P; Johnson K
J Pharmacol Exp Ther; 2016 Feb; 356(2):466-73. PubMed ID: 26578267
[TBL] [Abstract][Full Text] [Related]
8. Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody.
Hinke SA; Cieniewicz AM; Kirchner T; D'Aquino K; Nanjunda R; Aligo J; Perkinson R; Cooper P; Boayke K; Chiu ML; Jarantow S; Lacy ER; Liang Y; Johnson DL; Whaley JM; Lingham RB; Kihm AJ
Mol Metab; 2018 Apr; 10():87-99. PubMed ID: 29453154
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.
Corbin JA; Bhaskar V; Goldfine ID; Issafras H; Bedinger DH; Lau A; Michelson K; Gross LM; Maddux BA; Kuan HF; Tran C; Lao L; Handa M; Watson SR; Narasimha AJ; Zhu S; Levy R; Webster L; Wijesuriya SD; Liu N; Wu X; Chemla-Vogel D; Lee SR; Wong S; Wilcock D; Rubin P; White ML
MAbs; 2014; 6(1):262-72. PubMed ID: 24423625
[TBL] [Abstract][Full Text] [Related]
10. Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models.
Brierley GV; Siddle K; Semple RK
Diabetologia; 2018 Jul; 61(7):1662-1675. PubMed ID: 29700562
[TBL] [Abstract][Full Text] [Related]
11. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Zhang H; Wei J; Xue R; Wu JD; Zhao W; Wang ZZ; Wang SK; Zhou ZX; Song DQ; Wang YM; Pan HN; Kong WJ; Jiang JD
Metabolism; 2010 Feb; 59(2):285-92. PubMed ID: 19800084
[TBL] [Abstract][Full Text] [Related]
12. Orally efficacious novel small molecule 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose selectively and potently stimulates insulin receptor and alleviates diabetes.
Cao Y; Li Y; Kim J; Ren Y; Himmeldirk K; Liu Y; Qian Y; Liu F; Chen X
J Mol Endocrinol; 2013; 51(1):15-26. PubMed ID: 23549408
[TBL] [Abstract][Full Text] [Related]
13. Agonism and antagonism at the insulin receptor.
Knudsen L; Hansen BF; Jensen P; Pedersen TÅ; Vestergaard K; Schäffer L; Blagoev B; Oleksiewicz MB; Kiselyov VV; De Meyts P
PLoS One; 2012; 7(12):e51972. PubMed ID: 23300584
[TBL] [Abstract][Full Text] [Related]
14. 2'-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway.
Yinghao W; Qiaoli G; Guanfu L; Xiaoyun W; Xuanjun W; Jun S
J Diabetes Res; 2022; 2022():2042273. PubMed ID: 35502441
[TBL] [Abstract][Full Text] [Related]
15. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes.
Wei Z; Peterson JM; Lei X; Cebotaru L; Wolfgang MJ; Baldeviano GC; Wong GW
J Biol Chem; 2012 Mar; 287(13):10301-10315. PubMed ID: 22275362
[TBL] [Abstract][Full Text] [Related]
16. Discovery of a small molecule insulin receptor activator.
Salituro GM; Pelaez F; Zhang BB
Recent Prog Horm Res; 2001; 56():107-26. PubMed ID: 11237209
[TBL] [Abstract][Full Text] [Related]
17. Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation.
Yunn NO; Koh A; Han S; Lim JH; Park S; Lee J; Kim E; Jang SK; Berggren PO; Ryu SH
Nucleic Acids Res; 2015 Sep; 43(16):7688-701. PubMed ID: 26245346
[TBL] [Abstract][Full Text] [Related]
18. miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.
Agarwal P; Srivastava R; Srivastava AK; Ali S; Datta M
Biochim Biophys Acta; 2013 Aug; 1832(8):1294-303. PubMed ID: 23579070
[TBL] [Abstract][Full Text] [Related]
19. Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.
Pandey SK; Yu XX; Watts LM; Michael MD; Sloop KW; Rivard AR; Leedom TA; Manchem VP; Samadzadeh L; McKay RA; Monia BP; Bhanot S
J Biol Chem; 2007 May; 282(19):14291-9. PubMed ID: 17353188
[TBL] [Abstract][Full Text] [Related]
20. The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway.
Lu J; Zeng Y; Hou W; Zhang S; Li L; Luo X; Xi W; Chen Z; Xiang M
J Nutr Biochem; 2012 Nov; 23(11):1449-57. PubMed ID: 22278080
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
