307 related articles for article (PubMed ID: 22413863)
21. Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.
Łupicka-Słowik A; Psurski M; Grzywa R; Cuprych M; Ciekot J; Goldeman W; Wojaczyńska E; Wojaczyński J; Oleksyszyn J; Sieńczyk M
Invest New Drugs; 2020 Oct; 38(5):1350-1364. PubMed ID: 32270379
[TBL] [Abstract][Full Text] [Related]
22. Antitumor activity and pharmacodynamic biomarkers of a novel and orally available small-molecule antagonist of inhibitor of apoptosis proteins.
Sumi H; Yabuki M; Iwai K; Morimoto M; Hibino R; Inazuka M; Hashimoto K; Kosugi Y; Aoyama K; Yamamoto S; Yoshimatsu M; Yamasaki H; Tozawa R; Ishikawa T; Yoshida S
Mol Cancer Ther; 2013 Feb; 12(2):230-40. PubMed ID: 23243058
[TBL] [Abstract][Full Text] [Related]
23. Design of small-molecule Smac mimetics as IAP antagonists.
Wang S
Curr Top Microbiol Immunol; 2011; 348():89-113. PubMed ID: 21072626
[TBL] [Abstract][Full Text] [Related]
24. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
Cai Q; Sun H; Peng Y; Lu J; Nikolovska-Coleska Z; McEachern D; Liu L; Qiu S; Yang CY; Miller R; Yi H; Zhang T; Sun D; Kang S; Guo M; Leopold L; Yang D; Wang S
J Med Chem; 2011 Apr; 54(8):2714-26. PubMed ID: 21443232
[TBL] [Abstract][Full Text] [Related]
25. Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.
Paschall AV; Zimmerman MA; Torres CM; Yang D; Chen MR; Li X; Bieberich E; Bai A; Bielawski J; Bielawska A; Liu K
BMC Cancer; 2014 Jan; 14():24. PubMed ID: 24422988
[TBL] [Abstract][Full Text] [Related]
26. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
Cossu F; Mastrangelo E; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Seneci P; Scolastico C; Bolognesi M
Biochem Biophys Res Commun; 2009 Jan; 378(2):162-7. PubMed ID: 18992220
[TBL] [Abstract][Full Text] [Related]
27. Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells.
Grabinger T; Bode KJ; Demgenski J; Seitz C; Delgado ME; Kostadinova F; Reinhold C; Etemadi N; Wilhelm S; Schweinlin M; Hänggi K; Knop J; Hauck C; Walles H; Silke J; Wajant H; Nachbur U; W Wei-Lynn W; Brunner T
Gastroenterology; 2017 Mar; 152(4):867-879. PubMed ID: 27889570
[TBL] [Abstract][Full Text] [Related]
28. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
Wang J; Li W
J Pharmacol Exp Ther; 2014 May; 349(2):319-29. PubMed ID: 24623800
[TBL] [Abstract][Full Text] [Related]
29. IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Shekhar TM; Miles MA; Gupte A; Taylor S; Tascone B; Walkley CR; Hawkins CJ
Oncotarget; 2016 Jun; 7(23):33866-86. PubMed ID: 27129149
[TBL] [Abstract][Full Text] [Related]
30. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist.
Wong H; Gould SE; Budha N; Darbonne WC; Kadel EE; La H; Alicke B; Halladay JS; Erickson R; Portera C; Tolcher AW; Infante JR; Mamounas M; Flygare JA; Hop CE; Fairbrother WJ
Drug Metab Dispos; 2013 Dec; 41(12):2104-13. PubMed ID: 24041744
[TBL] [Abstract][Full Text] [Related]
31. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
Sun H; Nikolovska-Coleska Z; Lu J; Meagher JL; Yang CY; Qiu S; Tomita Y; Ueda Y; Jiang S; Krajewski K; Roller PP; Stuckey JA; Wang S
J Am Chem Soc; 2007 Dec; 129(49):15279-94. PubMed ID: 17999504
[TBL] [Abstract][Full Text] [Related]
32. The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
Choi YE; Butterworth M; Malladi S; Duckett CS; Cohen GM; Bratton SB
J Biol Chem; 2009 May; 284(19):12772-82. PubMed ID: 19258326
[TBL] [Abstract][Full Text] [Related]
33. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.
Peng Y; Sun H; Lu J; Liu L; Cai Q; Shen R; Yang CY; Yi H; Wang S
J Med Chem; 2012 Jan; 55(1):106-14. PubMed ID: 22148838
[TBL] [Abstract][Full Text] [Related]
34. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
Mastrangelo E; Cossu F; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Drago C; Seneci P; Scolastico C; Rizzo V; Bolognesi M
J Mol Biol; 2008 Dec; 384(3):673-89. PubMed ID: 18851976
[TBL] [Abstract][Full Text] [Related]
35. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
Allensworth JL; Sauer SJ; Lyerly HK; Morse MA; Devi GR
Breast Cancer Res Treat; 2013 Jan; 137(2):359-71. PubMed ID: 23225169
[TBL] [Abstract][Full Text] [Related]
36. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
[TBL] [Abstract][Full Text] [Related]
37. Estrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner.
Stanculescu A; Bembinster LA; Borgen K; Bergamaschi A; Wiley E; Frasor J
Horm Cancer; 2010 Jun; 1(3):127-35. PubMed ID: 21152357
[TBL] [Abstract][Full Text] [Related]
38. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.
Feltham R; Bettjeman B; Budhidarmo R; Mace PD; Shirley S; Condon SM; Chunduru SK; McKinlay MA; Vaux DL; Silke J; Day CL
J Biol Chem; 2011 May; 286(19):17015-28. PubMed ID: 21393245
[TBL] [Abstract][Full Text] [Related]
39. Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.
Peng Y; Sun H; Nikolovska-Coleska Z; Qiu S; Yang CY; Lu J; Cai Q; Yi H; Kang S; Yang D; Wang S
J Med Chem; 2008 Dec; 51(24):8158-62. PubMed ID: 19049347
[TBL] [Abstract][Full Text] [Related]
40. Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Talbott RL; Borzilleri RM; Chaudhry C; Fargnoli J; Shen H; Fairchild C; Barnhart B; Ortega M; McDonagh TE; Vuppugalla R; Vite GD; Hunt JT; Gottardis M; Naglich JG
Exp Cell Res; 2015 Nov; 338(2):251-60. PubMed ID: 26302264
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
