BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 22417220)

  • 1. Hypoxia-selective, enzymatic conversion of 6-nitroquinoline into a fluorescent helicene: pyrido[3,2-f]quinolino[6,5-c]cinnoline 3-oxide.
    Rajapakse A; Gates KS
    J Org Chem; 2012 Apr; 77(7):3531-7. PubMed ID: 22417220
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions.
    Rajapakse A; Linder C; Morrison RD; Sarkar U; Leigh ND; Barnes CL; Daniels JS; Gates KS
    Chem Res Toxicol; 2013 Apr; 26(4):555-63. PubMed ID: 23488987
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD; van Zijl P; Denny WA; Wilson WR
    J Med Chem; 1995 Mar; 38(7):1229-41. PubMed ID: 7707325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Relationship to hypoxia-selective cytotoxicity.
    Siim BG; Atwell GJ; Wilson WR
    Biochem Pharmacol; 1994 Oct; 48(8):1593-604. PubMed ID: 7980625
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fluorescent markers for hypoxic cells. A study of novel heterocyclic compounds that undergo bio-reductive binding.
    Hodgkiss RJ; Begg AC; Middleton RW; Parrick J; Stratford MR; Wardman P; Wilson GD
    Biochem Pharmacol; 1991 Feb; 41(4):533-41. PubMed ID: 1705123
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.
    Shen X; Laber CH; Sarkar U; Galazzi F; Johnson KM; Mahieu NG; Hillebrand R; Fuchs-Knotts T; Barnes CL; Baker GA; Gates KS
    J Org Chem; 2018 Mar; 83(6):3126-3131. PubMed ID: 29461834
    [TBL] [Abstract][Full Text] [Related]  

  • 7. FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells.
    Su J; Guise CP; Wilson WR
    Biochem J; 2013 May; 452(1):79-86. PubMed ID: 23480813
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells.
    Wang S; Wu X; Zhang Y; Zhang D; Xie B; Pan Z; Ouyang K; Peng T
    Org Biomol Chem; 2021 Apr; 19(15):3469-3478. PubMed ID: 33899896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia.
    Melo T; Ballinger JR; Rauth AM
    Biochem Pharmacol; 2000 Sep; 60(5):625-34. PubMed ID: 10927020
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and Crystal Structure of the Azoxydichinyl Helicene, Pyrido[3,2-f]quinolino[6,5-c]cinnoline 5-Oxide Monohydrate.
    Rajapakse A; Barnes CL; Gates KS
    J Chem Crystallogr; 2011 Nov; 41(11):1712-1716. PubMed ID: 22303091
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bioreductive fluorescent imaging agents: applications to tumour hypoxia.
    Elmes RB
    Chem Commun (Camb); 2016 Jul; 52(58):8935-56. PubMed ID: 26924320
    [TBL] [Abstract][Full Text] [Related]  

  • 12. One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450.
    Goeptar AR; te Koppele JM; van Maanen JM; Zoetemelk CE; Vermeulen NP
    Biochem Pharmacol; 1992 Jan; 43(2):343-52. PubMed ID: 1310854
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase.
    Dutton DR; Reed GA; Parkinson A
    Arch Biochem Biophys; 1989 Feb; 268(2):605-16. PubMed ID: 2464338
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Enzymatic activation of indolequinone-substituted 5-fluorodeoxyuridine prodrugs in hypoxic cells.
    Jiho Y; Kurihara R; Kawai K; Yamada H; Uto Y; Tanabe K
    Bioorg Med Chem Lett; 2019 Jun; 29(11):1304-1307. PubMed ID: 30975626
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A turn-on fluorescent probe for tumor hypoxia imaging in living cells.
    Cai Q; Yu T; Zhu W; Xu Y; Qian X
    Chem Commun (Camb); 2015 Oct; 51(79):14739-41. PubMed ID: 26295073
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release.
    Everett SA; Swann E; Naylor MA; Stratford MR; Patel KB; Tian N; Newman RG; Vojnovic B; Moody CJ; Wardman P
    Biochem Pharmacol; 2002 May; 63(9):1629-39. PubMed ID: 12007566
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.
    Kim D; Kadlubar FF; Teitel CH; Guengerich FP
    Chem Res Toxicol; 2004 Apr; 17(4):529-36. PubMed ID: 15089095
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An activatable probe for detecting alcoholic liver injury via multispectral optoacoustic tomography and fluorescence imaging.
    Chen J; Fang Y; Sun L; Zeng F; Wu S
    Chem Commun (Camb); 2020 Sep; 56(75):11102-11105. PubMed ID: 32812955
    [TBL] [Abstract][Full Text] [Related]  

  • 19. C(3)-functionalized cyclotriveratrylene derivative bearing quinolinyl group as a fluorescent probe for Cu(2+).
    Moriuchi-Kawakami T; Sato J; Shibutani Y
    Anal Sci; 2009 Mar; 25(3):449-52. PubMed ID: 19276606
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nitroaryl compounds as potential fluorescent probes for hypoxia. I. Chemical criteria and constraints.
    Wardman P; Clarke ED; Hodgkiss RJ; Middleton RW; Parrick J; Stratford MR
    Int J Radiat Oncol Biol Phys; 1984 Aug; 10(8):1347-51. PubMed ID: 6547939
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.