179 related articles for article (PubMed ID: 22422522)
1. Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Kögler M; Busson R; De Jonghe S; Rozenski J; Van Belle K; Louat T; Munier-Lehmann H; Herdewijn P
Chem Biodivers; 2012 Mar; 9(3):536-56. PubMed ID: 22422522
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.
Alexandrova LA; Chekhov VO; Shmalenyuk ER; Kochetkov SN; El-Asrar RA; Herdewijn P
Bioorg Med Chem; 2015 Nov; 23(22):7131-7. PubMed ID: 26482569
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
Kögler M; Vanderhoydonck B; De Jonghe S; Rozenski J; Van Belle K; Herman J; Louat T; Parchina A; Sibley C; Lescrinier E; Herdewijn P
J Med Chem; 2011 Jul; 54(13):4847-62. PubMed ID: 21657202
[TBL] [Abstract][Full Text] [Related]
4. Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.
Parchina A; Froeyen M; Margamuljana L; Rozenski J; De Jonghe S; Briers Y; Lavigne R; Herdewijn P; Lescrinier E
ChemMedChem; 2013 Aug; 8(8):1373-83. PubMed ID: 23836539
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Toti KS; Verbeke F; Risseeuw MD; Frecer V; Munier-Lehmann H; Van Calenbergh S
Bioorg Med Chem; 2013 Jan; 21(1):257-68. PubMed ID: 23199481
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.
Van Poecke S; Munier-Lehmann H; Helynck O; Froeyen M; Van Calenbergh S
Bioorg Med Chem; 2011 Dec; 19(24):7603-11. PubMed ID: 22061826
[TBL] [Abstract][Full Text] [Related]
7. Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
Sampathkumar P; Turley S; Ulmer JE; Rhie HG; Sibley CH; Hol WG
J Mol Biol; 2005 Oct; 352(5):1091-104. PubMed ID: 16139296
[TBL] [Abstract][Full Text] [Related]
8. Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.
Gasse C; Douguet D; Huteau V; Marchal G; Munier-Lehmann H; Pochet S
Bioorg Med Chem; 2008 Jun; 16(11):6075-85. PubMed ID: 18467107
[TBL] [Abstract][Full Text] [Related]
9. Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK).
Kato A; Yasuda Y; Kitamura Y; Kandeel M; Kitade Y
Parasitol Int; 2012 Sep; 61(3):501-3. PubMed ID: 22425904
[TBL] [Abstract][Full Text] [Related]
10. ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.
McGuigan C; Derudas M; Gonczy B; Hinsinger K; Kandil S; Pertusati F; Serpi M; Snoeck R; Andrei G; Balzarini J; McHugh TD; Maitra A; Akorli E; Evangelopoulos D; Bhakta S
Bioorg Med Chem; 2014 May; 22(9):2816-24. PubMed ID: 24690527
[TBL] [Abstract][Full Text] [Related]
11. 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Vanheusden V; Munier-Lehmann H; Froeyen M; Dugué L; Heyerick A; De Keukeleire D; Pochet S; Busson R; Herdewijn P; Van Calenbergh S
J Med Chem; 2003 Aug; 46(18):3811-21. PubMed ID: 12930144
[TBL] [Abstract][Full Text] [Related]
12. Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Vanheusden V; Munier-Lehmann H; Froeyen M; Busson R; Rozenski J; Herdewijn P; Van Calenbergh S
J Med Chem; 2004 Dec; 47(25):6187-94. PubMed ID: 15566289
[TBL] [Abstract][Full Text] [Related]
13. Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.
Van Daele I; Munier-Lehmann H; Froeyen M; Balzarini J; Van Calenbergh S
J Med Chem; 2007 Nov; 50(22):5281-92. PubMed ID: 17910427
[TBL] [Abstract][Full Text] [Related]
14. Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
Hunter JH; Gujjar R; Pang CK; Rathod PK
PLoS One; 2008 May; 3(5):e2237. PubMed ID: 18493582
[TBL] [Abstract][Full Text] [Related]
15. Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Familiar O; Munier-Lehmann H; Negri A; Gago F; Douguet D; Rigouts L; Hernández AI; Camarasa MJ; Pérez-Pérez MJ
ChemMedChem; 2008 Jul; 3(7):1083-93. PubMed ID: 18418833
[TBL] [Abstract][Full Text] [Related]
16. Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile.
Abu El Asrar R; Margamuljana L; Klaassen H; Nijs M; Marchand A; Chaltin P; Myllykallio H; Becker HF; De Jonghe S; Herdewijn P; Lescrinier E
Biochem Pharmacol; 2017 Jul; 135():69-78. PubMed ID: 28359706
[TBL] [Abstract][Full Text] [Related]
17. Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.
Pochet S; Dugué L; Labesse G; Delepierre M; Munier-Lehmann H
Chembiochem; 2003 Aug; 4(8):742-7. PubMed ID: 12898625
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.
Van Daele I; Munier-Lehmann H; Hendrickx PM; Marchal G; Chavarot P; Froeyen M; Qing L; Martins JC; Van Calenbergh S
ChemMedChem; 2006 Oct; 1(10):1081-90. PubMed ID: 16921580
[TBL] [Abstract][Full Text] [Related]
19. Structure-aided design of inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Van Calenbergh S
Verh K Acad Geneeskd Belg; 2006; 68(4):223-48. PubMed ID: 17214439
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
Biteau NG; Roy V; Lambry JC; Becker HF; Myllykallio H; Agrofoglio LA
Bioorg Med Chem; 2021 Sep; 46():116351. PubMed ID: 34391120
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
