224 related articles for article (PubMed ID: 22422993)
1. Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
Zhu J; Choi WS; McCoy JG; Negri A; Zhu J; Naini S; Li J; Shen M; Huang W; Bougie D; Rasmussen M; Aster R; Thomas CJ; Filizola M; Springer TA; Coller BS
Sci Transl Med; 2012 Mar; 4(125):125ra32. PubMed ID: 22422993
[TBL] [Abstract][Full Text] [Related]
2. Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening.
Zhu J; Zhu J; Negri A; Provasi D; Filizola M; Coller BS; Springer TA
Blood; 2010 Dec; 116(23):5050-9. PubMed ID: 20679525
[TBL] [Abstract][Full Text] [Related]
3. RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.
Li J; Vootukuri S; Shang Y; Negri A; Jiang JK; Nedelman M; Diacovo TG; Filizola M; Thomas CJ; Coller BS
Arterioscler Thromb Vasc Biol; 2014 Oct; 34(10):2321-9. PubMed ID: 25147334
[TBL] [Abstract][Full Text] [Related]
4. Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3.
Springer TA; Zhu J; Xiao T
J Cell Biol; 2008 Aug; 182(4):791-800. PubMed ID: 18710925
[TBL] [Abstract][Full Text] [Related]
5. Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand.
Negri A; Li J; Naini S; Coller BS; Filizola M
J Comput Aided Mol Des; 2012 Sep; 26(9):1005-15. PubMed ID: 22893377
[TBL] [Abstract][Full Text] [Related]
6. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists.
Hantgan RR; Stahle MC; Connor JH; Connor RF; Mousa SA
J Thromb Haemost; 2007 Mar; 5(3):542-50. PubMed ID: 17166246
[TBL] [Abstract][Full Text] [Related]
7. Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3).
Biris N; Abatzis M; Mitsios JV; Sakarellos-Daitsiotis M; Sakarellos C; Tsoukatos D; Tselepis AD; Michalis L; Sideris D; Konidou G; Soteriadou K; Tsikaris V
Eur J Biochem; 2003 Sep; 270(18):3760-7. PubMed ID: 12950259
[TBL] [Abstract][Full Text] [Related]
8. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.
Blue R; Kowalska MA; Hirsch J; Murcia M; Janczak CA; Harrington A; Jirouskova M; Li J; Fuentes R; Thornton MA; Filizola M; Poncz M; Coller BS
Blood; 2009 Jul; 114(1):195-201. PubMed ID: 19414864
[TBL] [Abstract][Full Text] [Related]
9. Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors.
Peter K; Schwarz M; Ylänne J; Kohler B; Moser M; Nordt T; Salbach P; Kübler W; Bode C
Blood; 1998 Nov; 92(9):3240-9. PubMed ID: 9787160
[TBL] [Abstract][Full Text] [Related]
10. The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanking the sequence RGD.
Rahman S; Lu X; Kakkar VV; Authi KS
Biochem J; 1995 Nov; 312 ( Pt 1)(Pt 1):223-32. PubMed ID: 7492316
[TBL] [Abstract][Full Text] [Related]
11. Human platelet alphaIIbeta3 integrin binding affinity and specificity of SJ874: antiplatelet efficacy versus aspirin.
Mousa SA; Forsythe M; Bozarth J; Jin F; Confalone PN
Coron Artery Dis; 2000 Oct; 11(7):563-70. PubMed ID: 11023245
[TBL] [Abstract][Full Text] [Related]
12. Platelet integrin alpha IIb beta 3 (GPIIb-IIIa) is not implicated in the binding of LDL to intact resting platelets.
Pedreño J; Fernández R; Cullaré C; Barceló A; Elorza MA; de Castellarnau C
Arterioscler Thromb Vasc Biol; 1997 Jan; 17(1):156-63. PubMed ID: 9012651
[TBL] [Abstract][Full Text] [Related]
13. Antagonism of the GPIIb/IIIa receptor with the nonpeptidic molecule BIBU52: inhibition of platelet aggregation in vitro and antithrombotic efficacy in vivo.
Guth BD; Seewaldt-Becker E; Himmelsbach F; Weisenberger H; Müller TH
J Cardiovasc Pharmacol; 1997 Aug; 30(2):261-72. PubMed ID: 9269956
[TBL] [Abstract][Full Text] [Related]
14. Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation.
Frelinger AL; Furman MI; Krueger LA; Barnard MR; Michelson AD
Circulation; 2001 Sep; 104(12):1374-9. PubMed ID: 11560852
[TBL] [Abstract][Full Text] [Related]
15. Variation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity.
Raborn J; Fu T; Wu X; Xiu Z; Li G; Luo BH
PLoS One; 2013; 8(10):e76793. PubMed ID: 24116162
[TBL] [Abstract][Full Text] [Related]
16. β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.
Lin FY; Zhu J; Eng ET; Hudson NE; Springer TA
J Biol Chem; 2016 Feb; 291(9):4537-46. PubMed ID: 26631735
[TBL] [Abstract][Full Text] [Related]
17. Human platelet activation is inhibited by the occupancy of glycoprotein IIb/IIIa receptor.
Padoin E; Alexandre A; Cavallini L; Polverino de Laureto P; Rao GH; Doni MG
Arch Biochem Biophys; 1996 Sep; 333(2):407-13. PubMed ID: 8809080
[TBL] [Abstract][Full Text] [Related]
18. RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation.
Jones ML; Harper MT; Aitken EW; Williams CM; Poole AW
J Thromb Haemost; 2010 Mar; 8(3):567-76. PubMed ID: 20002543
[TBL] [Abstract][Full Text] [Related]
19. [Conformational changes of the platelet membrane glycoprotein IIb-IIIa complex stimulated by a monoclonal antibody to the N-terminal segment of glycoprotein IIIa].
Khaspekova SG; Vyzova TV; Lukin VV; Tikhomirov OIu; Berndt M; Kouns W; Mazurov AV
Biokhimiia; 1996 Mar; 61(3):412-28. PubMed ID: 8724599
[TBL] [Abstract][Full Text] [Related]
20. Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb/IIIa) receptor.
Barre DE
Thromb Res; 2007; 119(5):601-7. PubMed ID: 16860375
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
