These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 22429468)

  • 1. Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.
    Meng Q; Zhao B; Xu Q; Xu X; Deng G; Li C; Luan L; Ren F; Wang H; Xu H; Xu Y; Zhang H; Xiang JN; Elliott JD; Guo TB; Zhao Y; Zhang W; Lu H; Lin X
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2794-7. PubMed ID: 22429468
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
    Vachal P; Toth LM; Hale JJ; Yan L; Mills SG; Chrebet GL; Koehane CA; Hajdu R; Milligan JA; Rosenbach MJ; Mandala S
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3684-7. PubMed ID: 16682185
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
    Gilmore JL; Sheppeck JE; Watterson SH; Haque L; Mukhopadhyay P; Tebben AJ; Galella MA; Shen DR; Yarde M; Cvijic ME; Borowski V; Gillooly K; Taylor T; McIntyre KW; Warrack B; Levesque PC; Li JP; Cornelius G; D'Arienzo C; Marino A; Balimane P; Salter-Cid L; Barrish JC; Pitts WJ; Carter PH; Xie J; Dyckman AJ
    J Med Chem; 2016 Jul; 59(13):6248-64. PubMed ID: 27309907
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis.
    Jin J; Hu J; Zhou W; Wang X; Xiao Q; Xue N; Yin D; Chen X
    Biochem Pharmacol; 2014 Jul; 90(1):50-61. PubMed ID: 24780445
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
    Quattropani A; Sauer WH; Crosignani S; Dorbais J; Gerber P; Gonzalez J; Marin D; Muzerelle M; Beltran F; Nichols A; Georgi K; Schneider M; Vitte PA; Eligert V; Novo-Perez L; Hantson J; Nock S; Carboni S; de Souza AL; Arrighi JF; Boschert U; Bombrun A
    ChemMedChem; 2015 Apr; 10(4):688-714. PubMed ID: 25735812
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
    Yamamoto R; Okada Y; Hirose J; Koshika T; Kawato Y; Maeda M; Saito R; Hattori K; Harada H; Nagasaka Y; Morokata T
    PLoS One; 2014; 9(10):e110819. PubMed ID: 25347187
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P
    Liu T; Jin J; Chen Y; Xi Q; Hu J; Jia W; Chen X; Li Y; Wang X; Yin D
    Bioorg Chem; 2019 Feb; 82():41-57. PubMed ID: 30268973
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.
    Buzard DJ; Schrader TO; Zhu X; Lehmann J; Johnson B; Kasem M; Kim SH; Kawasaki A; Lopez L; Moody J; Han S; Gao Y; Edwards J; Barden J; Thatte J; Gatlin J; Jones RM
    Bioorg Med Chem Lett; 2015 Feb; 25(3):659-63. PubMed ID: 25532755
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.
    Skidmore J; Heer J; Johnson CN; Norton D; Redshaw S; Sweeting J; Hurst D; Cridland A; Vesey D; Wall I; Ahmed M; Rivers D; Myatt J; Giblin G; Philpott K; Kumar U; Stevens A; Bit RA; Haynes A; Taylor S; Watson R; Witherington J; Demont E; Heightman TD
    J Med Chem; 2014 Dec; 57(24):10424-42. PubMed ID: 25431977
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis.
    Komiya T; Sato K; Shioya H; Inagaki Y; Hagiya H; Kozaki R; Imai M; Takada Y; Maeda T; Kurata H; Kurono M; Suzuki R; Otsuki K; Habashita H; Nakade S
    Clin Exp Immunol; 2013 Jan; 171(1):54-62. PubMed ID: 23199323
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.
    Deng Q; Clemas JA; Chrebet G; Fischer P; Hale JJ; Li Z; Mills SG; Bergstrom J; Mandala S; Mosley R; Parent SA
    Mol Pharmacol; 2007 Mar; 71(3):724-35. PubMed ID: 17170199
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of S1P agonists with a dihydronaphthalene scaffold.
    Kurata H; Kusumi K; Otsuki K; Suzuki R; Kurono M; Takada Y; Shioya H; Komiya T; Mizuno H; Ono T; Hagiya H; Minami M; Nakade S; Habashita H
    Bioorg Med Chem Lett; 2011 Jul; 21(13):3885-9. PubMed ID: 21641216
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P
    Xiao HY; Watterson SH; Langevine CM; Srivastava AS; Ko SS; Zhang Y; Cherney RJ; Guo WW; Gilmore JL; Sheppeck JE; Wu DR; Li P; Ramasamy D; Arunachalam P; Mathur A; Taylor TL; Shuster DJ; McIntyre KW; Shen DR; Yarde M; Cvijic ME; Marino AM; Balimane PV; Yang Z; Banas DM; Cornelius G; D'Arienzo CJ; Warrack BM; Lehman-McKeeman L; Salter-Cid LM; Xie J; Barrish JC; Carter PH; Dyckman AJ; Dhar TG
    J Med Chem; 2016 Nov; 59(21):9837-9854. PubMed ID: 27726358
    [TBL] [Abstract][Full Text] [Related]  

  • 14. SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.
    Yan L; Huo P; Hale JJ; Mills SG; Hajdu R; Keohane CA; Rosenbach MJ; Milligan JA; Shei GJ; Chrebet G; Bergstrom J; Card D; Mandala SM
    Bioorg Med Chem Lett; 2007 Feb; 17(3):828-31. PubMed ID: 17092714
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
    Watterson SH; Guo J; Spergel SH; Langevine CM; Moquin RV; Shen DR; Yarde M; Cvijic ME; Banas D; Liu R; Suchard SJ; Gillooly K; Taylor T; Rex-Rabe S; Shuster DJ; McIntyre KW; Cornelius G; D'Arienzo C; Marino A; Balimane P; Warrack B; Salter-Cid L; McKinnon M; Barrish JC; Carter PH; Pitts WJ; Xie J; Dyckman AJ
    J Med Chem; 2016 Mar; 59(6):2820-40. PubMed ID: 26924461
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
    Yan L; Huo P; Doherty G; Toth L; Hale JJ; Mills SG; Hajdu R; Keohane CA; Rosenbach MJ; Milligan JA; Shei GJ; Chrebet G; Bergstrom J; Card D; Quackenbush E; Wickham A; Mandala SM
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3679-83. PubMed ID: 16697189
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.
    Horan JC; Sanyal S; Choi Y; Hill-Drzewi M; Patnaude L; Anderson S; Fogal S; Mao C; Cook BN; Gueneva-Boucheva K; Fisher MB; Hickey E; Pack E; Bannen LC; Chan DS; Mac MB; Ng SM; Wang Y; Xu W; Modis LK; Lemieux RM
    Bioorg Med Chem Lett; 2014 Oct; 24(20):4807-11. PubMed ID: 25241927
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner.
    Galicia-Rosas G; Pikor N; Schwartz JA; Rojas O; Jian A; Summers-Deluca L; Ostrowski M; Nuesslein-Hildesheim B; Gommerman JL
    J Immunol; 2012 Oct; 189(7):3700-6. PubMed ID: 22933630
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P
    Kurata H; Kusumi K; Otsuki K; Suzuki R; Kurono M; Komiya T; Hagiya H; Mizuno H; Shioya H; Ono T; Takada Y; Maeda T; Matsunaga N; Kondo T; Tominaga S; Nunoya KI; Kiyoshi H; Komeno M; Nakade S; Habashita H
    J Med Chem; 2017 Dec; 60(23):9508-9530. PubMed ID: 29120624
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.
    Xu H; Zhang H; Luan L; Xu Y; Li C; Wang Y; Han F; Yang T; Ren F; Xiang JN; Elliott JD; Zhao Y; Guo TB; Lu H; Zhang W; Hirst D; Lindon M; Lin X
    Bioorg Med Chem Lett; 2012 Apr; 22(7):2456-9. PubMed ID: 22386243
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.