BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 22444597)

  • 1. Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin.
    Zhang W; Wang L; Kong L; Wang T; Chu Y; Deng Z; You D
    Chem Biol; 2012 Mar; 19(3):422-32. PubMed ID: 22444597
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae.
    Pulsawat N; Kitani S; Nihira T
    Gene; 2007 May; 393(1-2):31-42. PubMed ID: 17350183
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation.
    Kong L; Zhang W; Chooi YH; Wang L; Cao B; Deng Z; Chu Y; You D
    Cell Chem Biol; 2016 Apr; 23(4):508-16. PubMed ID: 27105283
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
    Seo JW; Ma M; Kwong T; Ju J; Lim SK; Jiang H; Lohman JR; Yang C; Cleveland J; Zazopoulos E; Farnet CM; Shen B
    Biochemistry; 2014 Dec; 53(49):7854-65. PubMed ID: 25405956
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin.
    Alt S; Wilkinson B
    ACS Chem Biol; 2015 Nov; 10(11):2468-79. PubMed ID: 26349074
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
    Tao M; Wang L; Wendt-Pienkowski E; George NP; Galm U; Zhang G; Coughlin JM; Shen B
    Mol Biosyst; 2007 Jan; 3(1):60-74. PubMed ID: 17216057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biosynthesis of the enediyne antitumor antibiotic C-1027.
    Liu W; Christenson SD; Standage S; Shen B
    Science; 2002 Aug; 297(5584):1170-3. PubMed ID: 12183628
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.
    Ohno S; Katsuyama Y; Tajima Y; Izumikawa M; Takagi M; Fujie M; Satoh N; Shin-Ya K; Ohnishi Y
    Chembiochem; 2015 Nov; 16(16):2385-91. PubMed ID: 26403163
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase.
    Paitan Y; Alon G; Orr E; Ron EZ; Rosenberg E
    J Mol Biol; 1999 Feb; 286(2):465-74. PubMed ID: 9973564
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.
    Ward SL; Hu Z; Schirmer A; Reid R; Revill WP; Reeves CD; Petrakovsky OV; Dong SD; Katz L
    Antimicrob Agents Chemother; 2004 Dec; 48(12):4703-12. PubMed ID: 15561847
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin.
    Daum M; Peintner I; Linnenbrink A; Frerich A; Weber M; Paululat T; Bechthold A
    Chembiochem; 2009 Apr; 10(6):1073-83. PubMed ID: 19266534
    [TBL] [Abstract][Full Text] [Related]  

  • 12. [Biosynthes of polyketide antibiotics by various actinomycin producing Streptomyces species].
    Alekhova TA; Novozhilova TIu
    Prikl Biokhim Mikrobiol; 2001; 37(3):309-16. PubMed ID: 11443900
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.
    Wang B; Song Y; Luo M; Chen Q; Ma J; Huang H; Ju J
    Org Lett; 2013 Mar; 15(6):1278-81. PubMed ID: 23438151
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.
    Li C; Roege KE; Kelly WL
    Chembiochem; 2009 Apr; 10(6):1064-72. PubMed ID: 19301315
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways.
    Palmu K; Ishida K; Mäntsälä P; Hertweck C; Metsä-Ketelä M
    Chembiochem; 2007 Sep; 8(13):1577-84. PubMed ID: 17654627
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of the post-polyketide synthase modification enzymes for fostriecin biosynthesis in Streptomyces pulveraceus.
    Liu XJ; Kong RX; Niu MS; Qiu RG; Tang L
    J Nat Prod; 2013 Apr; 76(4):524-9. PubMed ID: 23586868
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis.
    Qin Z; Devine R; Hutchings MI; Wilkinson B
    Nat Commun; 2019 Aug; 10(1):3611. PubMed ID: 31399587
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.
    Kudo F; Motegi A; Mizoue K; Eguchi T
    Chembiochem; 2010 Jul; 11(11):1574-82. PubMed ID: 20589823
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.
    He W; Lei J; Liu Y; Wang Y
    Arch Microbiol; 2008 May; 189(5):501-10. PubMed ID: 18214443
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.
    Wendt-Pienkowski E; Huang Y; Zhang J; Li B; Jiang H; Kwon H; Hutchinson CR; Shen B
    J Am Chem Soc; 2005 Nov; 127(47):16442-52. PubMed ID: 16305230
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.