These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

78 related articles for article (PubMed ID: 22445932)

  • 1. The γ-secretase blocker DAPT impairs recovery from lipopolysaccharide-induced inflammation in rat brain.
    Nasoohi S; Hemmati AA; Moradi F; Ahmadiani A
    Neuroscience; 2012 May; 210():99-109. PubMed ID: 22445932
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nuclear factor-κB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT.
    Cao Q; Li P; Lu J; Dheen ST; Kaur C; Ling EA
    J Neurosci Res; 2010 Sep; 88(12):2701-14. PubMed ID: 20648656
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the γ-secretase inhibitor DAPT has a nephroprotective effect.
    Huang R; Zhou Q; Veeraragoo P; Yu H; Xiao Z
    Ren Fail; 2011; 33(2):207-16. PubMed ID: 21332343
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilin 1/gamma-secretase is associated with cadmium-induced E-cadherin cleavage and COX-2 gene expression in T47D breast cancer cells.
    Park CS; Kim OS; Yun SM; Jo SA; Jo I; Koh YH
    Toxicol Sci; 2008 Dec; 106(2):413-22. PubMed ID: 18791180
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats.
    Hang CH; Shi JX; Tian J; Li JS; Wu W; Yin HX
    Brain Res; 2004 Nov; 1026(1):23-32. PubMed ID: 15476694
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.
    Lanz TA; Himes CS; Pallante G; Adams L; Yamazaki S; Amore B; Merchant KM
    J Pharmacol Exp Ther; 2003 Jun; 305(3):864-71. PubMed ID: 12626636
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?
    Connor TJ; Starr N; O'Sullivan JB; Harkin A
    Neurosci Lett; 2008 Aug; 441(1):29-34. PubMed ID: 18584961
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.
    Goldstein ME; Cao Y; Fiedler T; Toyn J; Iben L; Barten DM; Pierdomenico M; Corsa J; Prasad CV; Olson RE; Li YW; Zaczek R; Albright CF
    J Pharmacol Exp Ther; 2007 Oct; 323(1):102-8. PubMed ID: 17640949
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells.
    Pladzyk A; Reddy AB; Yadav UC; Tammali R; Ramana KV; Srivastava SK
    Invest Ophthalmol Vis Sci; 2006 Dec; 47(12):5395-403. PubMed ID: 17122129
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Corticosterone basal levels and vulnerability to LPS-induced neuroinflammation in the rat brain.
    Pérez-Nievas BG; Madrigal JL; García-Bueno B; Zoppi S; Leza JC
    Brain Res; 2010 Feb; 1315():159-68. PubMed ID: 20026014
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of nuclear factor-kappa B sensitises anterior pituitary cells to tumour necrosis factor-α- and lipopolysaccharide-induced apoptosis.
    Eijo G; Zárate S; Jaita G; Ferraris J; Magri ML; Zaldivar V; Radl D; Boti V; Pisera D; Seilicovich A
    J Neuroendocrinol; 2011 Aug; 23(8):651-9. PubMed ID: 21564349
    [TBL] [Abstract][Full Text] [Related]  

  • 13. beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid.
    Yu CJ; Wang WZ; Liu W
    Chin Med J (Engl); 2008 Aug; 121(15):1439-44. PubMed ID: 18959123
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo.
    Jin XH; Ohgami K; Shiratori K; Suzuki Y; Koyama Y; Yoshida K; Ilieva I; Tanaka T; Onoe K; Ohno S
    Exp Eye Res; 2006 May; 82(5):860-7. PubMed ID: 16309673
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
    Wen Y; Onyewuchi O; Yang S; Liu R; Simpkins JW
    Brain Res; 2004 May; 1009(1-2):1-8. PubMed ID: 15120577
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.
    Arslanova D; Yang T; Xu X; Wong ST; Augelli-Szafran CE; Xia W
    BMC Biotechnol; 2010 Mar; 10():24. PubMed ID: 20307292
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
    Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Influence of hydroxyethyl starch on lipopolysaccharide-induced tissue nuclear factor kappa B activation and systemic TNF-alpha expression.
    Tian J; Lin X; Li YH; Xu JG
    Acta Anaesthesiol Scand; 2005 Oct; 49(9):1311-7. PubMed ID: 16146468
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evidence that inducible nitric oxide synthase is involved in LPS-induced plasma leakage in rat skin through the activation of nuclear factor-kappaB.
    Iuvone T; D'Acquisto F; Van Osselaer N; Di Rosa M; Carnuccio R; Herman AG
    Br J Pharmacol; 1998 Apr; 123(7):1325-30. PubMed ID: 9579726
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.