These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 22446816)

  • 1. Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy.
    Madden JC; Hewitt M; Przybylak K; Vandebriel RJ; Piersma AH; Cronin MT
    Regul Toxicol Pharmacol; 2012 Jun; 63(1):140-54. PubMed ID: 22446816
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
    EFSA GMO Panel Working Group on Animal Feeding Trials
    Food Chem Toxicol; 2008 Mar; 46 Suppl 1():S2-70. PubMed ID: 18328408
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH).
    Lilienblum W; Dekant W; Foth H; Gebel T; Hengstler JG; Kahl R; Kramer PJ; Schweinfurth H; Wollin KM
    Arch Toxicol; 2008 Apr; 82(4):211-36. PubMed ID: 18322675
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Strengths and limitations of using repeat-dose toxicity studies to predict effects on fertility.
    Dent MP
    Regul Toxicol Pharmacol; 2007 Aug; 48(3):241-58. PubMed ID: 17512650
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Working in partnership to advance the 3Rs in toxicity testing.
    Holmes AM; Creton S; Chapman K
    Toxicology; 2010 Jan; 267(1-3):14-9. PubMed ID: 19903508
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing.
    Rothfuss A; Honma M; Czich A; Aardema MJ; Burlinson B; Galloway S; Hamada S; Kirkland D; Heflich RH; Howe J; Nakajima M; O'Donovan M; Plappert-Helbig U; Priestley C; Recio L; Schuler M; Uno Y; Martus HJ
    Mutat Res; 2011 Aug; 723(2):108-20. PubMed ID: 21182982
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Toxicity assessment strategies, data requirements, and risk assessment approaches to derive health based guidance values for non-relevant metabolites of plant protection products.
    Dekant W; Melching-Kollmuss S; Kalberlah F
    Regul Toxicol Pharmacol; 2010 Mar; 56(2):135-42. PubMed ID: 19883711
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Alternatives to the carcinogenicity bioassay: in silico methods, and the in vitro and in vivo mutagenicity assays.
    Benigni R; Bossa C; Tcheremenskaia O; Giuliani A
    Expert Opin Drug Metab Toxicol; 2010 Jul; 6(7):809-19. PubMed ID: 20438313
    [TBL] [Abstract][Full Text] [Related]  

  • 9. OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints.
    Vermeire T; Aldenberg T; Buist H; Escher S; Mangelsdorf I; Pauné E; Rorije E; Kroese D
    Regul Toxicol Pharmacol; 2013 Nov; 67(2):136-45. PubMed ID: 23385135
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program.
    Martin MT; Knudsen TB; Judson RS; Kavlock RJ; Dix DJ
    Syst Biol Reprod Med; 2012 Feb; 58(1):3-9. PubMed ID: 22239076
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation.
    De Wever B; Fuchs HW; Gaca M; Krul C; Mikulowski S; Poth A; Roggen EL; Vilà MR
    Toxicol In Vitro; 2012 Apr; 26(3):526-34. PubMed ID: 22269383
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation.
    Grindon C; Combes R; Cronin MT; Roberts DW; Garrod JF
    Altern Lab Anim; 2008 Feb; 36(1):65-80. PubMed ID: 18333715
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): present status.
    Box RJ; Spielmann H
    Arch Toxicol; 2005 Nov; 79(11):615-26. PubMed ID: 15940470
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Toxicology in the 21st century--working our way towards a visionary reality.
    Berg N; De Wever B; Fuchs HW; Gaca M; Krul C; Roggen EL
    Toxicol In Vitro; 2011 Jun; 25(4):874-81. PubMed ID: 21338664
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals.
    Beken S; Kasper P; van der Laan JW
    Adv Exp Med Biol; 2016; 856():33-64. PubMed ID: 27671719
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
    Adler S; Basketter D; Creton S; Pelkonen O; van Benthem J; Zuang V; Andersen KE; Angers-Loustau A; Aptula A; Bal-Price A; Benfenati E; Bernauer U; Bessems J; Bois FY; Boobis A; Brandon E; Bremer S; Broschard T; Casati S; Coecke S; Corvi R; Cronin M; Daston G; Dekant W; Felter S; Grignard E; Gundert-Remy U; Heinonen T; Kimber I; Kleinjans J; Komulainen H; Kreiling R; Kreysa J; Leite SB; Loizou G; Maxwell G; Mazzatorta P; Munn S; Pfuhler S; Phrakonkham P; Piersma A; Poth A; Prieto P; Repetto G; Rogiers V; Schoeters G; Schwarz M; Serafimova R; Tähti H; Testai E; van Delft J; van Loveren H; Vinken M; Worth A; Zaldivar JM
    Arch Toxicol; 2011 May; 85(5):367-485. PubMed ID: 21533817
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
    Kimber I; Dearman RJ; Betts CJ; Gerberick GF; Ryan CA; Kern PS; Patlewicz GY; Basketter DA
    Contact Dermatitis; 2006 Apr; 54(4):181-5. PubMed ID: 16650091
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation.
    Louisse J; Verwei M; Woutersen RA; Blaauboer BJ; Rietjens IM
    Expert Opin Drug Metab Toxicol; 2012 Jan; 8(1):11-27. PubMed ID: 22114915
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The 3Rs and animal welfare - conflict or the way forward?
    Rusche B
    ALTEX; 2003; 20(Suppl 1):63-76. PubMed ID: 14671703
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A review of the status of alternative approaches to animal testing and the development of integrated testing strategies for assessing the toxicity of chemicals under REACH--a summary of a DEFRA-funded project conducted by Liverpool John Moores University and FRAME.
    Grindon C; Combes R; Cronin MT; Roberts DW; Garrod J
    Altern Lab Anim; 2006 Mar; 34 Suppl 1():149-58. PubMed ID: 16555968
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.