BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 22447115)

  • 1. Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
    Kobayashi K; Yoshida A; Ejiri Y; Takagi S; Mimura H; Hosoda M; Matsuura T; Chiba K
    Drug Metab Pharmacokinet; 2012; 27(5):478-85. PubMed ID: 22447115
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human hepatocarcinoma functional liver cell-4 cell line exhibits high expression of drug-metabolizing enzymes in three-dimensional culture.
    Kato R; Shigemoto K; Akiyama H; Ieda A; Ijiri Y; Hayashi T
    Biol Pharm Bull; 2014; 37(11):1782-7. PubMed ID: 25366484
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
    Guillouzo A; Corlu A; Aninat C; Glaise D; Morel F; Guguen-Guillouzo C
    Chem Biol Interact; 2007 May; 168(1):66-73. PubMed ID: 17241619
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.
    Iwahori T; Matsuura T; Maehashi H; Sugo K; Saito M; Hosokawa M; Chiba K; Masaki T; Aizaki H; Ohkawa K; Suzuki T
    Hepatology; 2003 Mar; 37(3):665-73. PubMed ID: 12601364
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin.
    Lee SY; Lee JY; Kim YM; Kim SK; Oh SJ
    Toxicol Lett; 2015 Jun; 235(2):107-15. PubMed ID: 25835148
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
    Duret C; Daujat-Chavanieu M; Pascussi JM; Pichard-Garcia L; Balaguer P; Fabre JM; Vilarem MJ; Maurel P; Gerbal-Chaloin S
    Mol Pharmacol; 2006 Jul; 70(1):329-39. PubMed ID: 16608920
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates.
    Kobayashi K; Kajiwara E; Ishikawa M; Mimura H; Oka H; Ejiri Y; Hosoda M; Chiba K
    Drug Metab Pharmacokinet; 2013; 28(3):265-8. PubMed ID: 23229783
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
    Küblbeck J; Reinisalo M; Mustonen R; Honkakoski P
    Eur J Pharm Sci; 2010 Jul; 40(4):263-72. PubMed ID: 20381613
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
    Aninat C; Piton A; Glaise D; Le Charpentier T; Langouët S; Morel F; Guguen-Guillouzo C; Guillouzo A
    Drug Metab Dispos; 2006 Jan; 34(1):75-83. PubMed ID: 16204462
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.
    Sugatani J; Yamakawa K; Tonda E; Nishitani S; Yoshinari K; Degawa M; Abe I; Noguchi H; Miwa M
    Biochem Pharmacol; 2004 Mar; 67(5):989-1000. PubMed ID: 15104253
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Kanno Y; Tanuma N; Yazawa S; Zhao S; Inaba M; Nakamura S; Nemoto K; Inouye Y
    Drug Metab Dispos; 2016 Aug; 44(8):1158-63. PubMed ID: 27197997
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
    Sugawara M; Okamoto K; Kadowaki T; Kusano K; Fukamizu A; Yoshimura T
    Drug Metab Dispos; 2010 Mar; 38(3):526-33. PubMed ID: 20007293
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor.
    Sugatani J; Sueyoshi T; Negishi M; Miwa M
    Methods Enzymol; 2005; 400():92-104. PubMed ID: 16399345
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    Trubetskoy O; Marks B; Zielinski T; Yueh MF; Raucy J
    AAPS J; 2005 Mar; 7(1):E6-13. PubMed ID: 16146350
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.
    Niu Y; Wu Z; Shen Q; Song J; Luo Q; You H; Shi G; Qin W
    Dig Liver Dis; 2013 Dec; 45(12):1041-8. PubMed ID: 23891548
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation.
    Sivertsson L; Edebert I; Palmertz MP; Ingelman-Sundberg M; Neve EP
    Mol Pharmacol; 2013 Mar; 83(3):659-70. PubMed ID: 23264496
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).
    Jacobs MN; Nolan GT; Hood SR
    Toxicol Appl Pharmacol; 2005 Dec; 209(2):123-33. PubMed ID: 15885729
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression.
    Sugatani J; Osabe M; Kurosawa M; Kitamura N; Ikari A; Miwa M
    Drug Metab Dispos; 2010 Jan; 38(1):177-86. PubMed ID: 19797611
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.
    Lu L; Zhou J; Shi J; Peng XJ; Qi XX; Wang Y; Li FY; Zhou FY; Liu L; Liu ZQ
    PLoS One; 2015; 10(5):e0127524. PubMed ID: 26010150
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
    Takahata T; Ookawa K; Suto K; Tanaka M; Yano H; Nakashima O; Kojiro M; Tamura Y; Tateishi T; Sakata Y; Fukuda S
    Basic Clin Pharmacol Toxicol; 2008 Apr; 102(4):399-407. PubMed ID: 18248513
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.