BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 22449023)

  • 1. Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
    Rörsch F; Buscató E; Deckmann K; Schneider G; Schubert-Zsilavecz M; Geisslinger G; Proschak E; Grösch S
    J Med Chem; 2012 Apr; 55(8):3792-803. PubMed ID: 22449023
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors.
    Banerjee A; Pawar MY; Patil S; Yadav PS; Kadam PA; Kattige VG; Deshpande DS; Pednekar PV; Pisat MK; Gharat LA
    Bioorg Med Chem Lett; 2014 Oct; 24(20):4838-44. PubMed ID: 25260492
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
    Bruno A; Di Francesco L; Coletta I; Mangano G; Alisi MA; Polenzani L; Milanese C; Anzellotti P; Ricciotti E; Dovizio M; Di Francesco A; Tacconelli S; Capone ML; Patrignani P
    Biochem Pharmacol; 2010 Apr; 79(7):974-81. PubMed ID: 19925781
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.
    Hanke T; Rörsch F; Thieme TM; Ferreiros N; Schneider G; Geisslinger G; Proschak E; Grösch S; Schubert-Zsilavecz M
    Bioorg Med Chem; 2013 Dec; 21(24):7874-83. PubMed ID: 24183739
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
    Xu D; Rowland SE; Clark P; Giroux A; Côté B; Guiral S; Salem M; Ducharme Y; Friesen RW; Méthot N; Mancini J; Audoly L; Riendeau D
    J Pharmacol Exp Ther; 2008 Sep; 326(3):754-63. PubMed ID: 18524979
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1.
    Wiegard A; Hanekamp W; Griessbach K; Fabian J; Lehr M
    Eur J Med Chem; 2012 Feb; 48():153-63. PubMed ID: 22209272
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
    Mbalaviele G; Pauley AM; Shaffer AF; Zweifel BS; Mathialagan S; Mnich SJ; Nemirovskiy OV; Carter J; Gierse JK; Wang JL; Vazquez ML; Moore WM; Masferrer JL
    Biochem Pharmacol; 2010 May; 79(10):1445-54. PubMed ID: 20067770
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.
    De Simone R; Bruno I; Riccio R; Stadler K; Bauer J; Schaible AM; Laufer S; Werz O
    Bioorg Med Chem; 2012 Aug; 20(16):5012-6. PubMed ID: 22795900
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).
    Liedtke AJ; Keck PR; Lehmann F; Koeberle A; Werz O; Laufer SA
    J Med Chem; 2009 Aug; 52(15):4968-72. PubMed ID: 19719242
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.
    Rörsch F; Wobst I; Zettl H; Schubert-Zsilavecz M; Grösch S; Geisslinger G; Schneider G; Proschak E
    J Med Chem; 2010 Jan; 53(2):911-5. PubMed ID: 20025212
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
    Schaible AM; Traber H; Temml V; Noha SM; Filosa R; Peduto A; Weinigel C; Barz D; Schuster D; Werz O
    Biochem Pharmacol; 2013 Aug; 86(4):476-86. PubMed ID: 23623753
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
    Koeberle A; Rossi A; Zettl H; Pergola C; Dehm F; Bauer J; Greiner C; Reckel S; Hoernig C; Northoff H; Bernhard F; Dötsch V; Sautebin L; Schubert-Zsilavecz M; Werz O
    J Pharmacol Exp Ther; 2010 Mar; 332(3):840-8. PubMed ID: 19934399
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
    Koeberle A; Haberl EM; Rossi A; Pergola C; Dehm F; Northoff H; Troschuetz R; Sautebin L; Werz O
    Bioorg Med Chem; 2009 Dec; 17(23):7924-32. PubMed ID: 19884011
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.
    Shang E; Wu Y; Liu P; Liu Y; Zhu W; Deng X; He C; He S; Li C; Lai L
    Bioorg Med Chem Lett; 2014 Jun; 24(12):2764-7. PubMed ID: 24794107
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E₂ synthase-1 inhibitors.
    Shiro T; Takahashi H; Kakiguchi K; Inoue Y; Masuda K; Nagata H; Tobe M
    Bioorg Med Chem Lett; 2012 Jan; 22(1):285-8. PubMed ID: 22137787
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.
    De Simone R; Chini MG; Bruno I; Riccio R; Mueller D; Werz O; Bifulco G
    J Med Chem; 2011 Mar; 54(6):1565-75. PubMed ID: 21323313
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen.
    He S; Li C; Liu Y; Lai L
    J Med Chem; 2013 Apr; 56(8):3296-309. PubMed ID: 23527738
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.
    Wang J; Limburg D; Carter J; Mbalaviele G; Gierse J; Vazquez M
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1604-9. PubMed ID: 20144869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
    Riendeau D; Aspiotis R; Ethier D; Gareau Y; Grimm EL; Guay J; Guiral S; Juteau H; Mancini JA; Méthot N; Rubin J; Friesen RW
    Bioorg Med Chem Lett; 2005 Jul; 15(14):3352-5. PubMed ID: 15953724
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
    Chiasson JF; Boulet L; Brideau C; Chau A; Claveau D; Côté B; Ethier D; Giroux A; Guay J; Guiral S; Mancini J; Massé F; Méthot N; Riendeau D; Roy P; Rubin J; Xu D; Yu H; Ducharme Y; Friesen RW
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1488-92. PubMed ID: 21295979
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.