These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
266 related articles for article (PubMed ID: 22449444)
1. Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report. van der Laan JW; Chapin RE; Haenen B; Jacobs AC; Piersma A Regul Toxicol Pharmacol; 2012 Jun; 63(1):115-23. PubMed ID: 22449444 [TBL] [Abstract][Full Text] [Related]
2. Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds. Selderslaghs IW; Blust R; Witters HE Reprod Toxicol; 2012 Apr; 33(2):142-54. PubMed ID: 21871558 [TBL] [Abstract][Full Text] [Related]
3. Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Verwei M; van Burgsteden JA; Krul CA; van de Sandt JJ; Freidig AP Toxicol Lett; 2006 Aug; 165(1):79-87. PubMed ID: 16517103 [TBL] [Abstract][Full Text] [Related]
4. A different approach to validating screening assays for developmental toxicity. Daston GP; Chapin RE; Scialli AR; Piersma AH; Carney EW; Rogers JM; Friedman JM Birth Defects Res B Dev Reprod Toxicol; 2010 Dec; 89(6):526-30. PubMed ID: 21086491 [TBL] [Abstract][Full Text] [Related]
5. Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): present status. Box RJ; Spielmann H Arch Toxicol; 2005 Nov; 79(11):615-26. PubMed ID: 15940470 [TBL] [Abstract][Full Text] [Related]
6. Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH). Lilienblum W; Dekant W; Foth H; Gebel T; Hengstler JG; Kahl R; Kramer PJ; Schweinfurth H; Wollin KM Arch Toxicol; 2008 Apr; 82(4):211-36. PubMed ID: 18322675 [TBL] [Abstract][Full Text] [Related]
7. Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006. Chapin R; Stedman D; Paquette J; Streck R; Kumpf S; Deng S Toxicol In Vitro; 2007 Dec; 21(8):1545-51. PubMed ID: 17137747 [TBL] [Abstract][Full Text] [Related]
8. Evaluation of an alternative in vitro test battery for detecting reproductive toxicants. Piersma AH; Bosgra S; van Duursen MB; Hermsen SA; Jonker LR; Kroese ED; van der Linden SC; Man H; Roelofs MJ; Schulpen SH; Schwarz M; Uibel F; van Vugt-Lussenburg BM; Westerhout J; Wolterbeek AP; van der Burg B Reprod Toxicol; 2013 Jul; 38():53-64. PubMed ID: 23511061 [TBL] [Abstract][Full Text] [Related]
9. Development of a streamlined rat whole embryo culture assay for classifying teratogenic potential of pharmaceutical compounds. Zhang C; Cao J; Kenyon JR; Panzica-Kelly JM; Gong L; Augustine-Rauch K Toxicol Sci; 2012 Jun; 127(2):535-46. PubMed ID: 22430072 [TBL] [Abstract][Full Text] [Related]
10. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. EFSA GMO Panel Working Group on Animal Feeding Trials Food Chem Toxicol; 2008 Mar; 46 Suppl 1():S2-70. PubMed ID: 18328408 [TBL] [Abstract][Full Text] [Related]
11. Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures. van Dartel DA; Pennings JL; de la Fonteyne LJ; Brauers KJ; Claessen S; van Delft JH; Kleinjans JC; Piersma AH Toxicol Sci; 2011 Jan; 119(1):126-34. PubMed ID: 20935163 [TBL] [Abstract][Full Text] [Related]
12. The embryonic stem cell test combined with toxicogenomics as an alternative testing model for the assessment of developmental toxicity. van Dartel DA; Piersma AH Reprod Toxicol; 2011 Sep; 32(2):235-44. PubMed ID: 21575713 [TBL] [Abstract][Full Text] [Related]
13. Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles. de Jong E; Barenys M; Hermsen SA; Verhoef A; Ossendorp BC; Bessems JG; Piersma AH Toxicol Appl Pharmacol; 2011 Jun; 253(2):103-11. PubMed ID: 21443896 [TBL] [Abstract][Full Text] [Related]
14. Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs. Brannen KC; Chapin RE; Jacobs AC; Green ML ILAR J; 2016 Dec; 57(2):144-156. PubMed ID: 28053068 [TBL] [Abstract][Full Text] [Related]
16. In Vitro Developmental Toxicology Screens: A Report on the Progress of the Methodology and Future Applications. Zhang C; Ball J; Panzica-Kelly J; Augustine-Rauch K Chem Res Toxicol; 2016 Apr; 29(4):534-44. PubMed ID: 26766213 [TBL] [Abstract][Full Text] [Related]
18. Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Selderslaghs IW; Van Rompay AR; De Coen W; Witters HE Reprod Toxicol; 2009 Nov; 28(3):308-20. PubMed ID: 19447169 [TBL] [Abstract][Full Text] [Related]
19. Assaying embryotoxicity in the test tube: current limitations of the embryonic stem cell test (EST) challenging its applicability domain. Riebeling C; Hayess K; Peters AK; Steemans M; Spielmann H; Luch A; Seiler AE Crit Rev Toxicol; 2012 May; 42(5):443-64. PubMed ID: 22512667 [TBL] [Abstract][Full Text] [Related]
20. Alternative experimental approaches for interpreting skeletal findings in safety studies. Augustine-Rauch K Birth Defects Res B Dev Reprod Toxicol; 2007 Dec; 80(6):497-504. PubMed ID: 18157901 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]