These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

354 related articles for article (PubMed ID: 22451937)

  • 1. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
    Eicher T; Cha HJ; Seeger MA; Brandstätter L; El-Delik J; Bohnert JA; Kern WV; Verrey F; Grütter MG; Diederichs K; Pos KM
    Proc Natl Acad Sci U S A; 2012 Apr; 109(15):5687-92. PubMed ID: 22451937
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.
    Cha HJ; Müller RT; Pos KM
    Antimicrob Agents Chemother; 2014 Aug; 58(8):4767-72. PubMed ID: 24914123
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.
    Murakami S; Nakashima R; Yamashita E; Matsumoto T; Yamaguchi A
    Nature; 2006 Sep; 443(7108):173-9. PubMed ID: 16915237
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations.
    Feng Z; Hou T; Li Y
    Mol Biosyst; 2012 Oct; 8(10):2699-709. PubMed ID: 22825052
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket.
    Nakashima R; Sakurai K; Yamasaki S; Nishino K; Yamaguchi A
    Nature; 2011 Nov; 480(7378):565-9. PubMed ID: 22121023
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.
    Seeger MA; Diederichs K; Eicher T; Brandstätter L; Schiefner A; Verrey F; Pos KM
    Curr Drug Targets; 2008 Sep; 9(9):729-49. PubMed ID: 18781920
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
    Tam HK; Malviya VN; Foong WE; Herrmann A; Malloci G; Ruggerone P; Vargiu AV; Pos KM
    J Mol Biol; 2020 Feb; 432(4):861-877. PubMed ID: 31881208
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional rotation of the transporter AcrB: insights into drug extrusion from simulations.
    Schulz R; Vargiu AV; Collu F; Kleinekathöfer U; Ruggerone P
    PLoS Comput Biol; 2010 Jun; 6(6):e1000806. PubMed ID: 20548943
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump.
    Müller RT; Travers T; Cha HJ; Phillips JL; Gnanakaran S; Pos KM
    J Mol Biol; 2017 Dec; 429(24):3863-3874. PubMed ID: 28987732
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.
    Yue Z; Chen W; Zgurskaya HI; Shen J
    J Chem Theory Comput; 2017 Dec; 13(12):6405-6414. PubMed ID: 29117682
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors.
    Sennhauser G; Amstutz P; Briand C; Storchenegger O; Grütter MG
    PLoS Biol; 2007 Jan; 5(1):e7. PubMed ID: 17194213
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.
    Mowla R; Wang Y; Ma S; Venter H
    Biochim Biophys Acta Biomembr; 2018 Apr; 1860(4):878-886. PubMed ID: 28890187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.
    Ababou A; Koronakis V
    PLoS One; 2016; 11(7):e0159154. PubMed ID: 27403665
    [TBL] [Abstract][Full Text] [Related]  

  • 14. AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.
    Blair JM; Bavro VN; Ricci V; Modi N; Cacciotto P; Kleinekathӧfer U; Ruggerone P; Vargiu AV; Baylay AJ; Smith HE; Brandon Y; Galloway D; Piddock LJ
    Proc Natl Acad Sci U S A; 2015 Mar; 112(11):3511-6. PubMed ID: 25737552
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Drug transport mechanism of the AcrB efflux pump.
    Pos KM
    Biochim Biophys Acta; 2009 May; 1794(5):782-93. PubMed ID: 19166984
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Computer simulations suggest direct and stable tip to tip interaction between the outer membrane channel TolC and the isolated docking domain of the multidrug RND efflux transporter AcrB.
    Schmidt TH; Raunest M; Fischer N; Reith D; Kandt C
    Biochim Biophys Acta; 2016 Jul; 1858(7 Pt A):1419-26. PubMed ID: 27045078
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS.
    Brandstätter L; Sokolova L; Eicher T; Seeger MA; Briand C; Cha HJ; Cernescu M; Bohnert J; Kern WV; Brutschy B; Pos KM
    Biochim Biophys Acta; 2011 Sep; 1808(9):2189-96. PubMed ID: 21616055
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.
    Zuo Z; Wang B; Weng J; Wang W
    Sci Rep; 2015 Sep; 5():13905. PubMed ID: 26365278
    [TBL] [Abstract][Full Text] [Related]  

  • 19. New insights into the structural and functional involvement of the gate loop in AcrB export activity.
    Ababou A
    Biochim Biophys Acta Proteins Proteom; 2018 Feb; 1866(2):242-253. PubMed ID: 29126836
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.
    Vargiu AV; Collu F; Schulz R; Pos KM; Zacharias M; Kleinekathöfer U; Ruggerone P
    J Am Chem Soc; 2011 Jul; 133(28):10704-7. PubMed ID: 21707050
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.