138 related articles for article (PubMed ID: 22452605)
1. Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
Liu CP; Hsieh CH; Wu BN; Yeh JL; Dai ZK; Chai CY; Chen IJ
Inflamm Allergy Drug Targets; 2012 Aug; 11(4):251-61. PubMed ID: 22452605
[TBL] [Abstract][Full Text] [Related]
2. Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
Liu CP; Dai ZK; Huang CH; Yeh JL; Wu BN; Wu JR; Chen IJ
Kaohsiung J Med Sci; 2014 Jun; 30(6):267-78. PubMed ID: 24835346
[TBL] [Abstract][Full Text] [Related]
3. NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis.
Liu CP; Kuo MS; Wu BN; Chai CY; Huang HT; Chung PW; Chen IJ
Pulm Pharmacol Ther; 2014 Feb; 27(1):17-28. PubMed ID: 23518214
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
Wu BN; Chen CW; Liou SF; Yeh JL; Chung HH; Chen IJ
Mol Pharmacol; 2006 Sep; 70(3):977-85. PubMed ID: 16754782
[TBL] [Abstract][Full Text] [Related]
5. KMUP-1 inhibits H441 lung epithelial cell growth, migration and proinflammation via increased NO/CGMP and inhibited RHO kinase/VEGF signaling pathways.
Wu BN; Chen HY; Liu CP; Hsu LY; Chen IJ
Int J Immunopathol Pharmacol; 2011; 24(4):925-39. PubMed ID: 22230399
[TBL] [Abstract][Full Text] [Related]
6. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
Chung HH; Dai ZK; Wu BN; Yeh JL; Chai CY; Chu KS; Liu CP; Chen IJ
Br J Pharmacol; 2010 Jun; 160(4):971-86. PubMed ID: 20590592
[TBL] [Abstract][Full Text] [Related]
7. Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Tunctan B; Korkmaz B; Sari AN; Kacan M; Unsal D; Serin MS; Buharalioglu CK; Sahan-Firat S; Cuez T; Schunck WH; Manthati VL; Falck JR; Malik KU
Nitric Oxide; 2013 Sep; 33():18-41. PubMed ID: 23684565
[TBL] [Abstract][Full Text] [Related]
8. Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery.
Wu JR; Kao LP; Wu BN; Dai ZK; Wang YY; Chai CY; Chen IJ
Kaohsiung J Med Sci; 2015 May; 31(5):241-54. PubMed ID: 25910559
[TBL] [Abstract][Full Text] [Related]
9. KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance.
Liu CP; Yeh JL; Wu BN; Chai CY; Chen IJ; Lai WT
Br J Pharmacol; 2011 Jan; 162(1):126-35. PubMed ID: 20840538
[TBL] [Abstract][Full Text] [Related]
10. The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model.
Kobayashi K; Nishimura Y; Yamashita T; Nishiuma T; Satouchi M; Yokoyama M
Int Immunopharmacol; 2006 Jul; 6(7):1040-52. PubMed ID: 16714207
[TBL] [Abstract][Full Text] [Related]
11. NO donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
Kuo KK; Wu BN; Chiu EY; Tseng CJ; Yeh JL; Liu CP; Chai CY; Chen IJ
Int J Immunopathol Pharmacol; 2013; 26(1):93-106. PubMed ID: 23527712
[TBL] [Abstract][Full Text] [Related]
12. A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G.
Lin RJ; Wu BN; Lo YC; An LM; Dai ZK; Lin YT; Tang CS; Chen IJ
J Pharmacol Exp Ther; 2006 Feb; 316(2):709-17. PubMed ID: 16234412
[TBL] [Abstract][Full Text] [Related]
13. An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma.
Shin IS; Lee MY; Lim HS; Ha H; Seo CS; Kim JC; Shin HK
PLoS One; 2012; 7(9):e45734. PubMed ID: 23029210
[TBL] [Abstract][Full Text] [Related]
14. Kochia scoparia fruit attenuates allergic airway inflammation in ovalbumin (OVA)-induced murine asthma model.
Lee MY; Shin IS; Lim HS; Seo CS; Ha H; Shin HK
Inhal Toxicol; 2011 Dec; 23(14):938-46. PubMed ID: 22122306
[TBL] [Abstract][Full Text] [Related]
15. Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia.
Liu CM; Fan YC; Lo YC; Wu BN; Yeh JL; Chen IJ
Int J Urol; 2014 Jan; 21(1):87-92. PubMed ID: 23692571
[TBL] [Abstract][Full Text] [Related]
16. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways.
Lee ML; Sulistyowati E; Hsu JH; Huang BY; Dai ZK; Wu BN; Chao YY; Yeh JL
Molecules; 2019 Apr; 24(7):. PubMed ID: 30965668
[TBL] [Abstract][Full Text] [Related]
17. Effects of inducible nitric oxide synthase inhibition in bronchial vascular remodeling-induced by chronic allergic pulmonary inflammation.
Prado CM; Yano L; Rocha G; Starling CM; Capelozzi VL; Leick-Maldonado EA; Martins Mde A; Tibério IF
Exp Lung Res; 2011 Jun; 37(5):259-68. PubMed ID: 21585312
[TBL] [Abstract][Full Text] [Related]
18. KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin.
Yeh JL; Liu CP; Hsu JH; Tseng CJ; Wu PJ; Wang YY; Wu JR; Chen IJ
Kaohsiung J Med Sci; 2012 Nov; 28(11):567-76. PubMed ID: 23140764
[TBL] [Abstract][Full Text] [Related]
19. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.
Wu BN; Lin RJ; Lo YC; Shen KP; Wang CC; Lin YT; Chen IJ
Br J Pharmacol; 2004 Aug; 142(7):1105-14. PubMed ID: 15237094
[TBL] [Abstract][Full Text] [Related]
20. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization.
Liu CP; Yeh JL; Liou SF; Wu BN; Chen IJ
Kaohsiung J Med Sci; 2016 Feb; 32(2):55-67. PubMed ID: 26944323
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]