These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 22464683)

  • 1. Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase.
    Luniwal A; Wang L; Pavlovsky A; Erhardt PW; Viola RE
    Bioorg Med Chem; 2012 May; 20(9):2950-6. PubMed ID: 22464683
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.
    Thangavelu B; Bhansali P; Viola RE
    Bioorg Med Chem; 2015 Oct; 23(20):6622-31. PubMed ID: 26404410
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
    Pavlovsky AG; Thangavelu B; Bhansali P; Viola RE
    Acta Crystallogr D Biol Crystallogr; 2014 Dec; 70(Pt 12):3244-52. PubMed ID: 25478842
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Shape-based virtual screening, docking, and molecular dynamics simulations to identify Mtb-ASADH inhibitors.
    Kumar R; Garg P; Bharatam PV
    J Biomol Struct Dyn; 2015; 33(5):1082-93. PubMed ID: 24875451
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural characterization of inhibitors with selectivity against members of a homologous enzyme family.
    Pavlovsky AG; Liu X; Faehnle CR; Potente N; Viola RE
    Chem Biol Drug Des; 2012 Jan; 79(1):128-36. PubMed ID: 22039970
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of selective enzyme inhibitors by fragment library screening.
    Gao G; Liu X; Pavlovsky A; Viola RE
    J Biomol Screen; 2010 Oct; 15(9):1042-50. PubMed ID: 20855558
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
    Viola RE; Liu X; Ohren JF; Faehnle CR
    Acta Crystallogr D Biol Crystallogr; 2008 Mar; 64(Pt 3):321-30. PubMed ID: 18323627
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme.
    Dahal GP; Viola RE
    SLAS Discov; 2018 Jul; 23(6):520-531. PubMed ID: 29608391
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural-functional analysis of drug target aspartate semialdehyde dehydrogenase.
    Kumar R; R R; Diwakar V; Khan N; Kumar Meghwanshi G; Garg P
    Drug Discov Today; 2024 Mar; 29(3):103908. PubMed ID: 38301800
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacoinformatics analysis to identify inhibitors of Mtb-ASADH.
    Kumar R; Garg P; Bharatam PV
    J Biomol Struct Dyn; 2016; 34(1):1-14. PubMed ID: 25565373
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of anti-filarial leads against aspartate semialdehyde dehydrogenase of Wolbachia endosymbiont of Brugia malayi: combined molecular docking and molecular dynamics approaches.
    Amala M; Rajamanikandan S; Prabhu D; Surekha K; Jeyakanthan J
    J Biomol Struct Dyn; 2019 Feb; 37(2):394-410. PubMed ID: 29334340
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.
    Evitt AS; Cox RJ
    Mol Biosyst; 2011 May; 7(5):1564-75. PubMed ID: 21369577
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae.
    Blanco J; Moore RA; Kabaleeswaran V; Viola RE
    Protein Sci; 2003 Jan; 12(1):27-33. PubMed ID: 12493825
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.
    Vyas R; Tewari R; Weiss MS; Karthikeyan S
    Acta Crystallogr D Biol Crystallogr; 2012 Jun; 68(Pt 6):671-9. PubMed ID: 22683789
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
    Dahal GP; Viola RE
    Biochem Biophys Res Commun; 2018 Sep; 503(4):2848-2854. PubMed ID: 30107909
    [TBL] [Abstract][Full Text] [Related]  

  • 16. IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of
    Wang X; Yang R; Liu S; Guan Y; Xiao C; Li C; Meng J; Pang Y; Liu Y
    Emerg Microbes Infect; 2021 Dec; 10(1):2291-2299. PubMed ID: 34779708
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria.
    Faehnle CR; Le Coq J; Liu X; Viola RE
    J Biol Chem; 2006 Oct; 281(41):31031-40. PubMed ID: 16895909
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans.
    Dahal GP; Launder D; McKeone KMM; Hunter JP; Conti HR; Viola RE
    Drug Dev Res; 2020 Sep; 81(6):736-744. PubMed ID: 32383780
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.
    Arachea BT; Liu X; Pavlovsky AG; Viola RE
    Acta Crystallogr D Biol Crystallogr; 2010 Feb; 66(Pt 2):205-12. PubMed ID: 20124701
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and testing of selective inactivators against an antifungal enzyme target.
    Friday SN; Cheng DW; Zagler SG; Zanella BS; Dietz JD; Calbat CN; Roach LT; Bagnal C; Faile IS; Halkides CJ; Viola RE
    Drug Dev Res; 2022 Apr; 83(2):447-460. PubMed ID: 34469014
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.