140 related articles for article (PubMed ID: 22466437)
1. Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1.
Maruta H
Drug Discov Ther; 2011 Dec; 5(6):266-78. PubMed ID: 22466437
[TBL] [Abstract][Full Text] [Related]
2. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Demestre M; Messerli SM; Celli N; Shahhossini M; Kluwe L; Mautner V; Maruta H
Phytother Res; 2009 Feb; 23(2):226-30. PubMed ID: 18726924
[TBL] [Abstract][Full Text] [Related]
3. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.
Messerli SM; Ahn MR; Kunimasa K; Yanagihara M; Tatefuji T; Hashimoto K; Mautner V; Uto Y; Hori H; Kumazawa S; Kaji K; Ohta T; Maruta H
Phytother Res; 2009 Mar; 23(3):423-7. PubMed ID: 19003952
[TBL] [Abstract][Full Text] [Related]
4. Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines.
Hashimoto H; Messerli SM; Sudo T; Maruta H
Drug Discov Ther; 2009 Dec; 3(6):243-6. PubMed ID: 22495656
[TBL] [Abstract][Full Text] [Related]
5. A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor.
Hirokawa Y; Tikoo A; Huynh J; Utermark T; Hanemann CO; Giovannini M; Xiao GH; Testa JR; Wood J; Maruta H
Cancer J; 2004; 10(1):20-6. PubMed ID: 15000491
[TBL] [Abstract][Full Text] [Related]
6. Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice.
Hirokawa Y; Nheu T; Grimm K; Mautner V; Maeda S; Yoshida M; Komiyama K; Maruta H
Cancer Biol Ther; 2006 Mar; 5(3):305-9. PubMed ID: 16418572
[TBL] [Abstract][Full Text] [Related]
7. Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Hirokawa Y; Levitzki A; Lessene G; Baell J; Xiao Y; Zhu H; Maruta H
Cancer Lett; 2007 Jan; 245(1-2):242-51. PubMed ID: 16540233
[TBL] [Abstract][Full Text] [Related]
8. 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.
Takahashi H; Nguyen BCQ; Uto Y; Shahinozzaman M; Tawata S; Maruta H
Drug Discov Ther; 2017 May; 11(2):104-109. PubMed ID: 28442677
[TBL] [Abstract][Full Text] [Related]
9. Signal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228.
Hirokawa Y; Nakajima H; Hanemann CO; Kurtz A; Frahm S; Mautner V; Maruta H
Cancer Biol Ther; 2005 Apr; 4(4):379-81. PubMed ID: 15846074
[TBL] [Abstract][Full Text] [Related]
10. Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance.
Hirokawa Y; Arnold M; Nakajima H; Zalcberg J; Maruta H
Cancer Biol Ther; 2005 Sep; 4(9):956-60. PubMed ID: 16082189
[TBL] [Abstract][Full Text] [Related]
11. Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture.
Nguyen BC; Be Tu PT; Tawata S; Maruta H
Drug Discov Ther; 2015 Aug; 9(4):289-95. PubMed ID: 26370527
[TBL] [Abstract][Full Text] [Related]
12. From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
Maruta H; Ahn MR
Eur J Med Chem; 2017 Dec; 142():229-243. PubMed ID: 28814374
[TBL] [Abstract][Full Text] [Related]
13. Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity.
Maruta H
Phytother Res; 2014 May; 28(5):656-72. PubMed ID: 23943274
[TBL] [Abstract][Full Text] [Related]
14. The direct PAK1 inhibitor, TAT-PAK18, blocks preferentially the growth of human ovarian cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 423.
Hashimoto H; Sudo T; Maruta H; Nishimura R
Drug Discov Ther; 2010 Feb; 4(1):1-4. PubMed ID: 22491145
[TBL] [Abstract][Full Text] [Related]
15. Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture.
Nguyen BC; Taira N; Maruta H; Tawata S
Phytother Res; 2016 Jan; 30(1):120-7. PubMed ID: 26537230
[TBL] [Abstract][Full Text] [Related]
16. 1,2,3-Triazolyl ester of Ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer.
Nguyen BCQ; Takahashi H; Uto Y; Shahinozzaman MD; Tawata S; Maruta H
Eur J Med Chem; 2017 Jan; 126():270-276. PubMed ID: 27889630
[TBL] [Abstract][Full Text] [Related]
17. Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2.
Yi C; Wilker EW; Yaffe MB; Stemmer-Rachamimov A; Kissil JL
Cancer Res; 2008 Oct; 68(19):7932-7. PubMed ID: 18829550
[TBL] [Abstract][Full Text] [Related]
18. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.
Kissil JL; Wilker EW; Johnson KC; Eckman MS; Yaffe MB; Jacks T
Mol Cell; 2003 Oct; 12(4):841-9. PubMed ID: 14580336
[TBL] [Abstract][Full Text] [Related]
19. PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
Hawley E; Gehlhausen J; Karchugina S; Chow HY; Araiza-Olivera D; Radu M; Smith A; Burks C; Jiang L; Li X; Bessler W; Masters A; Edwards D; Burgin C; Jones D; Yates C; Clapp DW; Chernoff J; Park SJ
Hum Mol Genet; 2021 Aug; 30(17):1607-1617. PubMed ID: 34075397
[TBL] [Abstract][Full Text] [Related]
20. [NF1 (neurofibromatosis type 1)].
Maruta H; Nur-e-Kamal
Gan To Kagaku Ryoho; 1997 Sep; 24(11):1422-6. PubMed ID: 9309135
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
