BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

401 related articles for article (PubMed ID: 22479397)

  • 1. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.
    Laemmle A; Lechleiter A; Roh V; Schwarz C; Portmann S; Furer C; Keogh A; Tschan MP; Candinas D; Vorburger SA; Stroka D
    PLoS One; 2012; 7(3):e33433. PubMed ID: 22479397
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses.
    Yoon H; Shin SH; Shin DH; Chun YS; Park JW
    Biochem Biophys Res Commun; 2014 Jan; 444(1):36-43. PubMed ID: 24423936
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma.
    Zhou X; Chen J; Yi G; Deng M; Liu H; Liang M; Shi B; Fu X; Chen Y; Chen L; He Z; Wang J; Liu J
    Oncotarget; 2016 Jan; 7(1):873-84. PubMed ID: 26621849
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mild chronic hypoxia-induced HIF-2α interacts with c-MYC through competition with HIF-1α to induce hepatocellular carcinoma cell proliferation.
    Mu H; Yu G; Li H; Wang M; Cui Y; Zhang T; Song T; Liu C
    Cell Oncol (Dordr); 2021 Oct; 44(5):1151-1166. PubMed ID: 34339013
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.
    Zhang J; Cao J; Weng Q; Wu R; Yan Y; Jing H; Zhu H; He Q; Yang B
    PLoS One; 2010 Nov; 5(11):e13910. PubMed ID: 21085474
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia.
    Joo HY; Yun M; Jeong J; Park ER; Shin HJ; Woo SR; Jung JK; Kim YM; Park JJ; Kim J; Lee KH
    Biochem Biophys Res Commun; 2015 Jul; 462(4):294-300. PubMed ID: 25979359
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Lycium barbarum polysaccharides enhances SIRT1 expression and decreases MMP-9 and HIF-1α expressions in hypoxic pulmonary vascular smooth muscle cells].
    Zhu Y; Sun Y; Guan W; Yan Y; Zhang W; Bai L; Kong H; Li F
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2016 Jul; 32(7):906-10. PubMed ID: 27363270
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
    Lim JH; Lee YM; Chun YS; Chen J; Kim JE; Park JW
    Mol Cell; 2010 Jun; 38(6):864-78. PubMed ID: 20620956
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells.
    Lau CK; Yang ZF; Ho DW; Ng MN; Yeoh GC; Poon RT; Fan ST
    Clin Cancer Res; 2009 May; 15(10):3462-71. PubMed ID: 19447872
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols.
    Hong KS; Park JI; Kim MJ; Kim HB; Lee JW; Dao TT; Oh WK; Kang CD; Kim SH
    Toxicol Appl Pharmacol; 2012 Mar; 259(2):210-8. PubMed ID: 22245592
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinoma.
    Cui SY; Huang JY; Chen YT; Song HZ; Huang GC; De W; Wang R; Chen LB
    Cell Cycle; 2013 Sep; 12(17):2849-66. PubMed ID: 23966163
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo.
    Portmann S; Fahrner R; Lechleiter A; Keogh A; Overney S; Laemmle A; Mikami K; Montani M; Tschan MP; Candinas D; Stroka D
    Mol Cancer Ther; 2013 Apr; 12(4):499-508. PubMed ID: 23339189
    [TBL] [Abstract][Full Text] [Related]  

  • 13. RNAi Knockdown of Hypoxia-Inducible Factor-1α Decreased the Proliferation, Migration, and Invasion of Hypoxic Hepatocellular Carcinoma Cells.
    Chen C; Liu R; Wang J; Yan Z; Qian S; Zhang W
    Cell Biochem Biophys; 2015 Apr; 71(3):1677-84. PubMed ID: 25388848
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.
    Choi SH; Chung AR; Kang W; Park JY; Lee MS; Hwang SW; Kim DY; Kim SU; Ahn SH; Kim S; Han KH
    PLoS One; 2014; 9(7):e103304. PubMed ID: 25068796
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma.
    Wen Y; Zhou X; Lu M; He M; Tian Y; Liu L; Wang M; Tan W; Deng Y; Yang X; Mayer MP; Zou F; Chen X
    Oncogene; 2019 Mar; 38(11):1845-1859. PubMed ID: 30367150
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.
    Liu Q; Liu L; Zhao Y; Zhang J; Wang D; Chen J; He Y; Wu J; Zhang Z; Liu Z
    Mol Cancer Ther; 2011 Jun; 10(6):1113-23. PubMed ID: 21460102
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2.
    Ma L; Li G; Zhu H; Dong X; Zhao D; Jiang X; Li J; Qiao H; Ni S; Sun X
    Cancer Lett; 2014 Dec; 355(1):96-105. PubMed ID: 25218350
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney.
    Ryu DR; Yu MR; Kong KH; Kim H; Kwon SH; Jeon JS; Han DC; Noh H
    Aging Cell; 2019 Apr; 18(2):e12904. PubMed ID: 30614190
    [TBL] [Abstract][Full Text] [Related]  

  • 19. SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop.
    Cui CP; Wong CC; Kai AK; Ho DW; Lau EY; Tsui YM; Chan LK; Cheung TT; Chok KS; Chan ACY; Lo RC; Lee JM; Lee TK; Ng IOL
    Gut; 2017 Dec; 66(12):2149-2159. PubMed ID: 28258134
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling.
    Lin Y; Shen J; Li D; Ming J; Liu X; Zhang N; Lai J; Shi M; Ji Q; Xing Y
    Gen Comp Endocrinol; 2017 May; 246():63-70. PubMed ID: 28263817
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.