BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

85 related articles for article (PubMed ID: 22483389)

  • 21. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
    Pereira PJ; Bergner A; Macedo-Ribeiro S; Huber R; Matschiner G; Fritz H; Sommerhoff CP; Bode W
    Nature; 1998 Mar; 392(6673):306-11. PubMed ID: 9521329
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
    Costanzo MJ; Yabut SC; Zhang HC; White KB; de Garavilla L; Wang Y; Minor LK; Tounge BA; Barnakov AN; Lewandowski F; Milligan C; Spurlino JC; Abraham WM; Boswell-Smith V; Page CP; Maryanoff BE
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2114-21. PubMed ID: 18272363
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors.
    Rice KD; Gangloff AR; Kuo EY; Dener JM; Wang VR; Lum R; Newcomb WS; Havel C; Putnam D; Cregar L; Wong M; Warne RL
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2357-60. PubMed ID: 11055355
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti-tryptase monoclonal antibody B12.
    Ren S; Lawson AE; Carr M; Baumgarten CM; Schwartz LB
    J Immunol; 1997 Oct; 159(7):3540-8. PubMed ID: 9317153
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Definition of the extended substrate specificity determinants for beta-tryptases I and II.
    Harris JL; Niles A; Burdick K; Maffitt M; Backes BJ; Ellman JA; Kuntz I; Haak-Frendscho M; Craik CS
    J Biol Chem; 2001 Sep; 276(37):34941-7. PubMed ID: 11438529
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH.
    Fukuoka Y; Schwartz LB
    J Immunol; 2006 Mar; 176(5):3165-72. PubMed ID: 16493076
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens.
    Yang LK; Ng SP; Flotow H; Yoganathan K; Daramola BO; Soejarto DD; Buss AD; Butler MS
    Planta Med; 2005 Nov; 71(11):1071-2. PubMed ID: 16320213
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening.
    Liang G; Chen X; Aldous S; Pu SF; Mehdi S; Powers E; Xia T; Wang R
    Bioorg Med Chem Lett; 2012 Apr; 22(7):2450-5. PubMed ID: 22386244
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Upgrading a natural product: inhibition of human beta-tryptase by cyclotheonamide analogues.
    Schaschke N; Sommerhoff CP
    ChemMedChem; 2010 Mar; 5(3):367-70. PubMed ID: 20077463
    [No Abstract]   [Full Text] [Related]  

  • 30. Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
    Bisacchi GS; Slusarchyk WA; Bolton SA; Hartl KS; Jacobs G; Mathur A; Meng W; Ogletree ML; Pi Z; Sutton JC; Treuner U; Zahler R; Zhao G; Seiler SM
    Bioorg Med Chem Lett; 2004 May; 14(9):2227-31. PubMed ID: 15081014
    [TBL] [Abstract][Full Text] [Related]  

  • 31. 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase.
    Wong T; Groutas CS; Mohan S; Lai Z; Alliston KR; Vu N; Schechter NM; Groutas WC
    Arch Biochem Biophys; 2005 Apr; 436(1):1-7. PubMed ID: 15752703
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.
    Nazaré M; Essrich M; Will DW; Matter H; Ritter K; Urmann M; Bauer A; Schreuder H; Dudda A; Czech J; Lorenz M; Laux V; Wehner V
    Bioorg Med Chem Lett; 2004 Aug; 14(16):4191-5. PubMed ID: 15261268
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Tryptase inhibitors in the treatment of pulmonary diseases.
    Gangloff AR
    Curr Opin Investig Drugs; 2000 Sep; 1(1):79-85. PubMed ID: 11249600
    [No Abstract]   [Full Text] [Related]  

  • 34. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.
    Selwood T; Elrod KC; Schechter NM
    Biol Chem; 2003 Dec; 384(12):1605-11. PubMed ID: 14719803
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Tryptase inhibitors: a patent review.
    Ni WW; Cao MD; Huang W; Meng L; Wei JF
    Expert Opin Ther Pat; 2017 Aug; 27(8):919-928. PubMed ID: 28425830
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The role of ecotin dimerization in protease inhibition.
    Eggers CT; Wang SX; Fletterick RJ; Craik CS
    J Mol Biol; 2001 May; 308(5):975-91. PubMed ID: 11352586
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G.
    Maryanoff BE
    J Med Chem; 2004 Feb; 47(4):769-87. PubMed ID: 14761180
    [No Abstract]   [Full Text] [Related]  

  • 38. Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.
    Nazaré M; Essrich M; Will DW; Matter H; Ritter K; Urmann M; Bauer A; Schreuder H; Czech J; Lorenz M; Laux V; Wehner V
    Bioorg Med Chem Lett; 2004 Aug; 14(16):4197-201. PubMed ID: 15261269
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa.
    Mederski WW; Dorsch D; Anzali S; Gleitz J; Cezanne B; Tsaklakidis C
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3763-9. PubMed ID: 15203158
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Thermodynamic criterion for the conformation of P1 residues of substrates and of inhibitors in complexes with serine proteinases.
    Qasim MA; Lu SM; Ding J; Bateman KS; James MN; Anderson S; Song J; Markley JL; Ganz PJ; Saunders CW; Laskowski M
    Biochemistry; 1999 Jun; 38(22):7142-50. PubMed ID: 10353824
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.