BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 22490700)

  • 1. Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells.
    Amsailale R; Van Den Neste E; Arts A; Starczewska E; Bontemps F; Smal C
    Biochem Pharmacol; 2012 Jul; 84(1):43-51. PubMed ID: 22490700
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
    Månsson E; Flordal E; Liliemark J; Spasokoukotskaja T; Elford H; Lagercrantz S; Eriksson S; Albertioni F
    Biochem Pharmacol; 2003 Jan; 65(2):237-47. PubMed ID: 12504799
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues.
    McSorley T; Ort S; Hazra S; Lavie A; Konrad M
    FEBS Lett; 2008 Mar; 582(5):720-4. PubMed ID: 18258203
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine.
    van Haperen VW; Veerman G; Vermorken JB; Pinedo HM; Peters G
    Biochem Pharmacol; 1996 Apr; 51(7):911-8. PubMed ID: 8651941
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
    Hazra S; Szewczak A; Ort S; Konrad M; Lavie A
    Biochemistry; 2011 Apr; 50(14):2870-80. PubMed ID: 21351740
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
    Baker JA; Wickremsinhe ER; Li CH; Oluyedun OA; Dantzig AH; Hall SD; Qian YW; Ring BJ; Wrighton SA; Guo Y
    Drug Metab Dispos; 2013 Mar; 41(3):541-5. PubMed ID: 23230131
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.
    Klanova M; Lorkova L; Vit O; Maswabi B; Molinsky J; Pospisilova J; Vockova P; Mavis C; Lateckova L; Kulvait V; Vejmelkova D; Jaksa R; Hernandez F; Trneny M; Vokurka M; Petrak J; Klener P
    Mol Cancer; 2014 Jun; 13():159. PubMed ID: 24972933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy.
    Johnsamuel J; Eriksson S; Oliveira M; Tjarks W
    Bioorg Med Chem; 2005 Jul; 13(13):4160-7. PubMed ID: 15876539
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nucleotide specificity of human deoxycytidine kinase.
    Shewach DS; Reynolds KK; Hertel L
    Mol Pharmacol; 1992 Sep; 42(3):518-24. PubMed ID: 1406603
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity.
    Hapke DM; Stegmann AP; Mitchell BS
    Cancer Res; 1996 May; 56(10):2343-7. PubMed ID: 8625309
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase.
    Zhu C; Johansson M; Permert J; Karlsson A
    Biochem Pharmacol; 1998 Oct; 56(8):1035-40. PubMed ID: 9776315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells.
    Lotfi K; Månsson E; Spasokoukotskaja T; Pettersson B; Liliemark J; Peterson C; Eriksson S; Albertioni F
    Clin Cancer Res; 1999 Sep; 5(9):2438-44. PubMed ID: 10499616
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
    Bergman AM; Munch-Petersen B; Jensen PB; Sehested M; Veerman G; Voorn DA; Smid K; Pinedo HM; Peters GJ
    Biochem Pharmacol; 2001 Jun; 61(11):1401-8. PubMed ID: 11331076
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET.
    Lee JT; Campbell DO; Satyamurthy N; Czernin J; Radu CG
    J Nucl Med; 2012 Feb; 53(2):275-80. PubMed ID: 22302964
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase.
    Bouffard DY; Laliberté J; Momparler RL
    Biochem Pharmacol; 1993 May; 45(9):1857-61. PubMed ID: 8494545
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene.
    Beauséjour CM; Gagnon J; Primeau M; Momparler RL
    Biochem Biophys Res Commun; 2002 May; 293(5):1478-84. PubMed ID: 12054682
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
    Bergman AM; Pinedo HM; Jongsma AP; Brouwer M; Ruiz van Haperen VW; Veerman G; Leyva A; Eriksson S; Peters GJ
    Biochem Pharmacol; 1999 Feb; 57(4):397-406. PubMed ID: 9933028
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
    Hodge LS; Taub ME; Tracy TS
    Drug Metab Dispos; 2011 Nov; 39(11):2013-6. PubMed ID: 21832002
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase.
    Sabini E; Hazra S; Konrad M; Lavie A
    J Med Chem; 2008 Jul; 51(14):4219-25. PubMed ID: 18570408
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis for substrate promiscuity of dCK.
    Sabini E; Hazra S; Ort S; Konrad M; Lavie A
    J Mol Biol; 2008 May; 378(3):607-21. PubMed ID: 18377927
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.