These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

72 related articles for article (PubMed ID: 22501024)

  • 1. Novel phosphoramidate prodrugs of N-acetyl-(D)-glucosamine with antidegenerative activity on bovine and human cartilage explants.
    Serpi M; Bibbo R; Rat S; Roberts H; Hughes C; Caterson B; Alcaraz MJ; Gibert AT; Verson CR; McGuigan C
    J Med Chem; 2012 May; 55(10):4629-39. PubMed ID: 22501024
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery.
    McGuigan C; Serpi M; Bibbo R; Roberts H; Hughes C; Caterson B; Gibert AT; Verson CR
    J Med Chem; 2008 Sep; 51(18):5807-12. PubMed ID: 18714981
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel biologically active series of N-acetylglucosamine derivatives for the suppressive activities on GAG release.
    Cao T; Li Y; Jiang L; Yuan L; Dong L; Li Y; Yin S
    Carbohydr Res; 2016 Oct; 433():73-9. PubMed ID: 27454655
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Diastereoselective synthesis of aryloxy phosphoramidate prodrugs of 3'-deoxy-2',3'-didehydrothymidine monophosphate.
    Roman CA; Balzarini J; Meier C
    J Med Chem; 2010 Nov; 53(21):7675-81. PubMed ID: 20945915
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes.
    Igarashi M; Kaga I; Takamori Y; Sakamoto K; Miyazawa K; Nagaoka I
    Int J Mol Med; 2011 Jun; 27(6):821-7. PubMed ID: 21455564
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
    Zhao RY; Erickson HK; Leece BA; Reid EE; Goldmacher VS; Lambert JM; Chari RV
    J Med Chem; 2012 Jan; 55(2):766-82. PubMed ID: 22148292
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function.
    Yudoh K; Nguyen vT; Nakamura H; Hongo-Masuko K; Kato T; Nishioka K
    Arthritis Res Ther; 2005; 7(2):R380-91. PubMed ID: 15743486
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs.
    Taniguchi S; Ryu J; Seki M; Sumino T; Tokuhashi Y; Esumi M
    J Orthop Res; 2012 May; 30(5):673-8. PubMed ID: 22058013
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
    McGuigan C; Murziani P; Slusarczyk M; Gonczy B; Vande Voorde J; Liekens S; Balzarini J
    J Med Chem; 2011 Oct; 54(20):7247-58. PubMed ID: 21892829
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
    Krecmerová M; Holý A; Andrei G; Pomeisl K; Tichý T; Brehová P; Masojídková M; Dracínský M; Pohl R; Laflamme G; Naesens L; Hui H; Cihlar T; Neyts J; De Clercq E; Balzarini J; Snoeck R
    J Med Chem; 2010 Oct; 53(19):6825-37. PubMed ID: 20809641
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
    Baragi VM; Becher G; Bendele AM; Biesinger R; Bluhm H; Boer J; Deng H; Dodd R; Essers M; Feuerstein T; Gallagher BM; Gege C; Hochgürtel M; Hofmann M; Jaworski A; Jin L; Kiely A; Korniski B; Kroth H; Nix D; Nolte B; Piecha D; Powers TS; Richter F; Schneider M; Steeneck C; Sucholeiki I; Taveras A; Timmermann A; Van Veldhuizen J; Weik J; Wu X; Xia B
    Arthritis Rheum; 2009 Jul; 60(7):2008-18. PubMed ID: 19565489
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
    McGuigan C; Madela K; Aljarah M; Bourdin C; Arrica M; Barrett E; Jones S; Kolykhalov A; Bleiman B; Bryant KD; Ganguly B; Gorovits E; Henson G; Hunley D; Hutchins J; Muhammad J; Obikhod A; Patti J; Walters CR; Wang J; Vernachio J; Ramamurty CV; Battina SK; Chamberlain S
    J Med Chem; 2011 Dec; 54(24):8632-45. PubMed ID: 22039920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transdermal permeation of novel n-acetyl-glucosamine/NSAIDs mutual prodrugs.
    Israel B; Garner ST; Thakare M; Elder D; Abney T; Azadi P; Beach JW; Price JC; Ahmed H; Capomacchia AC
    Pharm Dev Technol; 2012; 17(1):48-54. PubMed ID: 20858066
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
    Liang Y; Narayanasamy J; Schinazi RF; Chu CK
    Bioorg Med Chem; 2006 Apr; 14(7):2178-89. PubMed ID: 16314108
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of n-3 fatty acids on cartilage metabolism.
    Curtis CL; Rees SG; Cramp J; Flannery CR; Hughes CE; Little CB; Williams R; Wilson C; Dent CM; Harwood JL; Caterson B
    Proc Nutr Soc; 2002 Aug; 61(3):381-9. PubMed ID: 12230798
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Does oral glucosamine prevent the loss of proteoglycans in a rabbit model of osteoarthritis? Comment on the article by Tiraloche et al.
    Lammi M
    Arthritis Rheum; 2005 Nov; 52(11):3680; author reply 3680-81. PubMed ID: 16258912
    [No Abstract]   [Full Text] [Related]  

  • 17. Benzo[d]isothiazol-3-yl-benzamidines: a class of protective agents on culture of human cartilage and chondrocytes stimulated by IL-1beta.
    Vicini P; Incerti M; Cardile V; Garufi F; Ronsisvalle S; Panico AM
    ChemMedChem; 2007 Jan; 2(1):113-9. PubMed ID: 17131461
    [TBL] [Abstract][Full Text] [Related]  

  • 18. S-acyl-2-thioethyl phosphoramidate diester derivatives as mononucleotide prodrugs.
    Egron D; Imbach JL; Gosselin G; Aubertin AM; Périgaud C
    J Med Chem; 2003 Oct; 46(21):4564-71. PubMed ID: 14521418
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of R and S enantiomers and a racemic mixture of carprofen on the production and release of proteoglycan and prostaglandin E2 from equine chondrocytes and cartilage explants.
    Armstrong S; Lees P
    Am J Vet Res; 1999 Jan; 60(1):98-104. PubMed ID: 9918155
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.
    Huh JE; Baek YH; Ryu SR; Lee JD; Choi DY; Park DS
    Int Immunopharmacol; 2009 Feb; 9(2):230-40. PubMed ID: 19100343
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.