BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 22503743)

  • 1. The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.
    Yalowich JC; Wu X; Zhang R; Kanagasabai R; Hornbaker M; Hasinoff BB
    Biochem Pharmacol; 2012 Jul; 84(1):52-8. PubMed ID: 22503743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells.
    Rao VA; Klein SR; Agama KK; Toyoda E; Adachi N; Pommier Y; Shacter EB
    Cancer Res; 2009 Feb; 69(3):948-57. PubMed ID: 19176392
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα.
    Wilson JT; Jiang X; McGill BC; Lisic EC; Deweese JE
    Chem Res Toxicol; 2016 Apr; 29(4):649-58. PubMed ID: 26982206
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.
    Ishiguro K; Lin ZP; Penketh PG; Shyam K; Zhu R; Baumann RP; Zhu YL; Sartorelli AC; Rutherford TJ; Ratner ES
    Biochem Pharmacol; 2014 Oct; 91(3):312-22. PubMed ID: 25130544
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
    Huang H; Chen Q; Ku X; Meng L; Lin L; Wang X; Zhu C; Wang Y; Chen Z; Li M; Jiang H; Chen K; Ding J; Liu H
    J Med Chem; 2010 Apr; 53(8):3048-64. PubMed ID: 20353152
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
    Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
    Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
    Sehested M; Wessel I; Jensen LH; Holm B; Oliveri RS; Kenwrick S; Creighton AM; Nitiss JL; Jensen PB
    Cancer Res; 1998 Apr; 58(7):1460-8. PubMed ID: 9537249
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.
    Liang H; Wu X; Yalowich JC; Hasinoff BB
    Mol Pharmacol; 2008 Mar; 73(3):686-96. PubMed ID: 18045852
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
    Zeglis BM; Divilov V; Lewis JS
    J Med Chem; 2011 Apr; 54(7):2391-8. PubMed ID: 21391686
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.
    de Oliveira JF; Lima TS; Vendramini-Costa DB; de Lacerda Pedrosa SCB; Lafayette EA; da Silva RMF; de Almeida SMV; de Moura RO; Ruiz ALTG; de Carvalho JE; de Lima MDCA
    Eur J Med Chem; 2017 Aug; 136():305-314. PubMed ID: 28505535
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.
    Hasinoff BB; Wu X; Patel D; Kanagasabai R; Karmahapatra S; Yalowich JC
    J Pharmacol Exp Ther; 2016 Feb; 356(2):397-409. PubMed ID: 26660439
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.
    Qin Y; Meng L; Hu C; Duan W; Zuo Z; Lin L; Zhang X; Ding J
    Mol Cancer Ther; 2007 Sep; 6(9):2429-40. PubMed ID: 17876042
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects.
    Hasinoff BB; Wu X; Yalowich JC; Goodfellow V; Laufer RS; Adedayo O; Dmitrienko GI
    Anticancer Drugs; 2006 Aug; 17(7):825-37. PubMed ID: 16926632
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.
    Park S; Hong E; Kwak SY; Jun KY; Lee ES; Kwon Y; Na Y
    Eur J Med Chem; 2016 Nov; 123():211-225. PubMed ID: 27484510
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
    Park S; Kadayat TM; Jun KY; Thapa Magar TB; Bist G; Shrestha A; Lee ES; Kwon Y
    Eur J Med Chem; 2017 Jan; 125():14-28. PubMed ID: 27643560
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor.
    Kadayat TM; Park C; Jun KY; Thapa Magar TB; Bist G; Yoo HY; Kwon Y; Lee ES
    Eur J Med Chem; 2015 Jan; 90():302-14. PubMed ID: 25437617
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ.
    Keck JM; Conner JD; Wilson JT; Jiang X; Lisic EC; Deweese JE
    Chem Res Toxicol; 2019 Oct; 32(10):2135-2143. PubMed ID: 31512855
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
    Infante Lara L; Sledge A; Laradji A; Okoro CO; Osheroff N
    Bioorg Med Chem Lett; 2017 Feb; 27(3):586-589. PubMed ID: 27998679
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells.
    Pourpak A; Landowski TH; Dorr RT
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1109-17. PubMed ID: 17351106
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Trypanotoxic activity of thiosemicarbazone iron chelators.
    Ellis S; Sexton DW; Steverding D
    Exp Parasitol; 2015 Mar; 150():7-12. PubMed ID: 25595343
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.