BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 22505410)

  • 41. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
    Forsch RA; Queener SF; Rosowsky A
    Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.
    Graffner-Nordberg M; Kolmodin K; Aqvist J; Queener SF; Hallberg A
    Eur J Pharm Sci; 2004 May; 22(1):43-54. PubMed ID: 15113582
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines.
    Donkor IO; Li H; Queener SF
    Eur J Med Chem; 2003 Jun; 38(6):605-11. PubMed ID: 12832132
    [TBL] [Abstract][Full Text] [Related]  

  • 44. N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
    Gangjee A; Adair OO; Pagley M; Queener SF
    J Med Chem; 2008 Oct; 51(19):6195-200. PubMed ID: 18771252
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
    Gangjee A; Mavandadi F; Queener SF
    J Med Chem; 1997 Mar; 40(7):1173-7. PubMed ID: 9089339
    [TBL] [Abstract][Full Text] [Related]  

  • 46. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A; Papoulis AT; Queener SF
    J Med Chem; 1997 Oct; 40(22):3694-9. PubMed ID: 9357537
    [TBL] [Abstract][Full Text] [Related]  

  • 47. QSAR analysis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminopyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
    Jain P; Soni LK; Gupta AK; Kashkedikar SG
    Indian J Biochem Biophys; 2005 Oct; 42(5):315-20. PubMed ID: 23923540
    [TBL] [Abstract][Full Text] [Related]  

  • 48. 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A; Mota CE; Wright JE; Freisheim JH; Heusner JJ; McCormack JJ; Queener SF
    J Med Chem; 1993 Oct; 36(21):3103-12. PubMed ID: 8230096
    [TBL] [Abstract][Full Text] [Related]  

  • 49. A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase.
    Southerland WM
    J Comput Aided Mol Des; 1994 Apr; 8(2):113-22. PubMed ID: 8064329
    [TBL] [Abstract][Full Text] [Related]  

  • 50. 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A; Papoulis AT; Queener SF
    J Med Chem; 1998 Mar; 41(6):913-8. PubMed ID: 9526565
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.
    Gangjee A; Yang J; Queener SF
    Bioorg Med Chem; 2006 Dec; 14(24):8341-51. PubMed ID: 17010625
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim.
    Nowak W; Cody V; Wojtczak A
    Acta Biochim Pol; 2001; 48(4):903-16. PubMed ID: 11996001
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
    Gangjee A; Shi J; Queener SF; Barrows LR; Kisliuk RL
    J Med Chem; 1993 Oct; 36(22):3437-43. PubMed ID: 8230134
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
    J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
    Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A
    Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
    Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
    J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
    Piper JR; Johnson CA; Krauth CA; Carter RL; Hosmer CA; Queener SF; Borotz SE; Pfefferkorn ER
    J Med Chem; 1996 Mar; 39(6):1271-80. PubMed ID: 8632434
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens.
    Bag S; Tawari NR; Degani MS; Queener SF
    Bioorg Med Chem; 2010 May; 18(9):3187-97. PubMed ID: 20363634
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
    Cody V; Luft JR; Pangborn W; Gangjee A
    Acta Crystallogr D Biol Crystallogr; 2003 Sep; 59(Pt 9):1603-9. PubMed ID: 12925791
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Three-dimensional quantitative structure-activity and structure-selectivity relationships of dihydrofolate reductase inhibitors.
    Sutherland JJ; Weaver DF
    J Comput Aided Mol Des; 2004 May; 18(5):309-31. PubMed ID: 15595459
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.