BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 22506770)

  • 1. The chemistry and biology of the bryostatins: potential PKC inhibitors in clinical development.
    Ruan BF; Zhu HL
    Curr Med Chem; 2012; 19(16):2652-64. PubMed ID: 22506770
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review.
    Raghuvanshi R; Bharate SB
    Curr Top Med Chem; 2020; 20(12):1124-1135. PubMed ID: 32209043
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Marine natural products: bryostatins in preclinical and clinical studies.
    Kollár P; Rajchard J; Balounová Z; Pazourek J
    Pharm Biol; 2014 Feb; 52(2):237-42. PubMed ID: 24033119
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxic Bryostatin Derivatives from the South China Sea Bryozoan Bugula neritina.
    Yu HB; Yang F; Li YY; Gan JH; Jiao WH; Lin HW
    J Nat Prod; 2015 May; 78(5):1169-73. PubMed ID: 25932671
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.
    Wender PA; Verma VA
    Org Lett; 2008 Aug; 10(15):3331-4. PubMed ID: 18588309
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
    Kedei N; Lewin NE; Géczy T; Selezneva J; Braun DC; Chen J; Herrmann MA; Heldman MR; Lim L; Mannan P; Garfield SH; Poudel YB; Cummins TJ; Rudra A; Blumberg PM; Keck GE
    ACS Chem Biol; 2013 Apr; 8(4):767-77. PubMed ID: 23369356
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
    Szallasi Z; Du L; Levine R; Lewin NE; Nguyen PN; Williams MD; Pettit GR; Blumberg PM
    Cancer Res; 1996 May; 56(9):2105-11. PubMed ID: 8616857
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The clinical development of the bryostatins.
    Clamp A; Jayson GC
    Anticancer Drugs; 2002 Aug; 13(7):673-83. PubMed ID: 12187323
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
    Ryckbosch SM; Wender PA; Pande VS
    Nat Commun; 2017 Feb; 8(1):6. PubMed ID: 28232750
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemistry and clinical biology of the bryostatins.
    Mutter R; Wills M
    Bioorg Med Chem; 2000 Aug; 8(8):1841-60. PubMed ID: 11003129
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.
    Plummer S; Manning T; Baker T; McGreggor T; Patel M; Wylie G; Phillips D
    Bioorg Med Chem Lett; 2016 May; 26(10):2489-2497. PubMed ID: 27068183
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.
    Abdelnabi R; Staveness D; Near KE; Wender PA; Delang L; Neyts J; Leyssen P
    Biochem Pharmacol; 2016 Nov; 120():15-21. PubMed ID: 27664855
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of bryostatin 20: a symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina.
    Lopanik N; Gustafson KR; Lindquist N
    J Nat Prod; 2004 Aug; 67(8):1412-4. PubMed ID: 15332866
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.
    Kedei N; Kraft MB; Keck GE; Herald CL; Melody N; Pettit GR; Blumberg PM
    J Nat Prod; 2015 Apr; 78(4):896-900. PubMed ID: 25808573
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency.
    Zhao X; Kedei N; Michalowski A; Lewin NE; Keck GE; Blumberg PM
    Chembiochem; 2018 May; 19(10):1049-1059. PubMed ID: 29517836
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
    Wender PA; DeBrabander J; Harran PG; Jimenez JM; Koehler MF; Lippa B; Park CM; Siedenbiedel C; Pettit GR
    Proc Natl Acad Sci U S A; 1998 Jun; 95(12):6624-9. PubMed ID: 9618462
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
    Irie K; Yanagita RC
    Chem Rec; 2014 Apr; 14(2):251-67. PubMed ID: 24677503
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.
    Wender PA; Hinkle KW; Koehler MF; Lippa B
    Med Res Rev; 1999 Sep; 19(5):388-407. PubMed ID: 10502742
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.
    Sudek S; Lopanik NB; Waggoner LE; Hildebrand M; Anderson C; Liu H; Patel A; Sherman DH; Haygood MG
    J Nat Prod; 2007 Jan; 70(1):67-74. PubMed ID: 17253852
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina.
    Sharp KH; Davidson SK; Haygood MG
    ISME J; 2007 Dec; 1(8):693-702. PubMed ID: 18059493
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.