164 related articles for article (PubMed ID: 22506770)
1. The chemistry and biology of the bryostatins: potential PKC inhibitors in clinical development.
Ruan BF; Zhu HL
Curr Med Chem; 2012; 19(16):2652-64. PubMed ID: 22506770
[TBL] [Abstract][Full Text] [Related]
2. Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review.
Raghuvanshi R; Bharate SB
Curr Top Med Chem; 2020; 20(12):1124-1135. PubMed ID: 32209043
[TBL] [Abstract][Full Text] [Related]
3. Marine natural products: bryostatins in preclinical and clinical studies.
Kollár P; Rajchard J; Balounová Z; Pazourek J
Pharm Biol; 2014 Feb; 52(2):237-42. PubMed ID: 24033119
[TBL] [Abstract][Full Text] [Related]
4. Cytotoxic Bryostatin Derivatives from the South China Sea Bryozoan Bugula neritina.
Yu HB; Yang F; Li YY; Gan JH; Jiao WH; Lin HW
J Nat Prod; 2015 May; 78(5):1169-73. PubMed ID: 25932671
[TBL] [Abstract][Full Text] [Related]
5. The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.
Wender PA; Verma VA
Org Lett; 2008 Aug; 10(15):3331-4. PubMed ID: 18588309
[TBL] [Abstract][Full Text] [Related]
6. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N; Lewin NE; Géczy T; Selezneva J; Braun DC; Chen J; Herrmann MA; Heldman MR; Lim L; Mannan P; Garfield SH; Poudel YB; Cummins TJ; Rudra A; Blumberg PM; Keck GE
ACS Chem Biol; 2013 Apr; 8(4):767-77. PubMed ID: 23369356
[TBL] [Abstract][Full Text] [Related]
7. The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
Szallasi Z; Du L; Levine R; Lewin NE; Nguyen PN; Williams MD; Pettit GR; Blumberg PM
Cancer Res; 1996 May; 56(9):2105-11. PubMed ID: 8616857
[TBL] [Abstract][Full Text] [Related]
8. The clinical development of the bryostatins.
Clamp A; Jayson GC
Anticancer Drugs; 2002 Aug; 13(7):673-83. PubMed ID: 12187323
[TBL] [Abstract][Full Text] [Related]
9. Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
Ryckbosch SM; Wender PA; Pande VS
Nat Commun; 2017 Feb; 8(1):6. PubMed ID: 28232750
[TBL] [Abstract][Full Text] [Related]
10. Chemistry and clinical biology of the bryostatins.
Mutter R; Wills M
Bioorg Med Chem; 2000 Aug; 8(8):1841-60. PubMed ID: 11003129
[TBL] [Abstract][Full Text] [Related]
11. Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.
Plummer S; Manning T; Baker T; McGreggor T; Patel M; Wylie G; Phillips D
Bioorg Med Chem Lett; 2016 May; 26(10):2489-2497. PubMed ID: 27068183
[TBL] [Abstract][Full Text] [Related]
12. Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.
Abdelnabi R; Staveness D; Near KE; Wender PA; Delang L; Neyts J; Leyssen P
Biochem Pharmacol; 2016 Nov; 120():15-21. PubMed ID: 27664855
[TBL] [Abstract][Full Text] [Related]
13. Structure of bryostatin 20: a symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina.
Lopanik N; Gustafson KR; Lindquist N
J Nat Prod; 2004 Aug; 67(8):1412-4. PubMed ID: 15332866
[TBL] [Abstract][Full Text] [Related]
14. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.
Kedei N; Kraft MB; Keck GE; Herald CL; Melody N; Pettit GR; Blumberg PM
J Nat Prod; 2015 Apr; 78(4):896-900. PubMed ID: 25808573
[TBL] [Abstract][Full Text] [Related]
15. Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency.
Zhao X; Kedei N; Michalowski A; Lewin NE; Keck GE; Blumberg PM
Chembiochem; 2018 May; 19(10):1049-1059. PubMed ID: 29517836
[TBL] [Abstract][Full Text] [Related]
16. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Wender PA; DeBrabander J; Harran PG; Jimenez JM; Koehler MF; Lippa B; Park CM; Siedenbiedel C; Pettit GR
Proc Natl Acad Sci U S A; 1998 Jun; 95(12):6624-9. PubMed ID: 9618462
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
Irie K; Yanagita RC
Chem Rec; 2014 Apr; 14(2):251-67. PubMed ID: 24677503
[TBL] [Abstract][Full Text] [Related]
18. The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.
Wender PA; Hinkle KW; Koehler MF; Lippa B
Med Res Rev; 1999 Sep; 19(5):388-407. PubMed ID: 10502742
[TBL] [Abstract][Full Text] [Related]
19. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.
Sudek S; Lopanik NB; Waggoner LE; Hildebrand M; Anderson C; Liu H; Patel A; Sherman DH; Haygood MG
J Nat Prod; 2007 Jan; 70(1):67-74. PubMed ID: 17253852
[TBL] [Abstract][Full Text] [Related]
20. Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina.
Sharp KH; Davidson SK; Haygood MG
ISME J; 2007 Dec; 1(8):693-702. PubMed ID: 18059493
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]