77 related articles for article (PubMed ID: 22508690)
1. Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.
Mutoh T; Kawamura N; Hirabayashi Y; Shima S; Miyashita T; Ito S; Asakura K; Araki W; Cazzaniga E; Muto E; Masserini M
FASEB J; 2012 Jul; 26(7):3065-74. PubMed ID: 22508690
[TBL] [Abstract][Full Text] [Related]
2. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
Ma L; Ohyagi Y; Miyoshi K; Sakae N; Motomura K; Taniwaki T; Furuya H; Takeda K; Tabira T; Kira J
J Alzheimers Dis; 2009; 16(3):565-75. PubMed ID: 19276551
[TBL] [Abstract][Full Text] [Related]
3. Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
Miyoshi K; Ohyagi Y; Sakae N; Motomura K; Ma L; Taniwaki T; Furuya H; Tabira T; Kira J
J Alzheimers Dis; 2009; 16(3):551-64. PubMed ID: 19276550
[TBL] [Abstract][Full Text] [Related]
4. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
Hamano T; Mutoh T; Tabira T; Araki W; Kuriyama M; Mihara T; Yano S; Yamamoto H
Brain Res Mol Brain Res; 2005 Jun; 137(1-2):70-6. PubMed ID: 15950763
[TBL] [Abstract][Full Text] [Related]
5. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
[TBL] [Abstract][Full Text] [Related]
6. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
7. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Qi Y; Morishima-Kawashima M; Sato T; Mitsumori R; Ihara Y
Biochemistry; 2003 Feb; 42(4):1042-52. PubMed ID: 12549925
[TBL] [Abstract][Full Text] [Related]
8. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
Wen PH; Hof PR; Chen X; Gluck K; Austin G; Younkin SG; Younkin LH; DeGasperi R; Gama Sosa MA; Robakis NK; Haroutunian V; Elder GA
Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
[TBL] [Abstract][Full Text] [Related]
9. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
10. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
Katayama T; Imaizumi K; Sato N; Miyoshi K; Kudo T; Hitomi J; Morihara T; Yoneda T; Gomi F; Mori Y; Nakano Y; Takeda J; Tsuda T; Itoyama Y; Murayama O; Takashima A; St George-Hyslop P; Takeda M; Tohyama M
Nat Cell Biol; 1999 Dec; 1(8):479-85. PubMed ID: 10587643
[TBL] [Abstract][Full Text] [Related]
11. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
[TBL] [Abstract][Full Text] [Related]
12. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
Terro F; Czech C; Esclaire F; Elyaman W; Yardin C; Baclet MC; Touchet N; Tremp G; Pradier L; Hugon J
J Neurosci Res; 2002 Aug; 69(4):530-9. PubMed ID: 12210846
[TBL] [Abstract][Full Text] [Related]
13. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Jankowsky JL; Slunt HH; Gonzales V; Jenkins NA; Copeland NG; Borchelt DR
Neurobiol Aging; 2004 Aug; 25(7):885-92. PubMed ID: 15212842
[TBL] [Abstract][Full Text] [Related]
14. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; Ramabhadran TV; Kwok JB; Schofield PR; Carter T; Gandy S; Martins RN
Mol Psychiatry; 2004 Jun; 9(6):594-602. PubMed ID: 14993906
[TBL] [Abstract][Full Text] [Related]
15. Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.
Michelsen KA; Korr H; Steinbusch HW; Schmitz C
Brain Res; 2010 Feb; 1316():139-44. PubMed ID: 20034479
[TBL] [Abstract][Full Text] [Related]
16. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
17. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
18. Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease.
Ryu YS; Park SY; Jung MS; Yoon SH; Kwen MY; Lee SY; Choi SH; Radnaabazar C; Kim MK; Kim H; Kim K; Song WJ; Chung SH
J Neurochem; 2010 Nov; 115(3):574-84. PubMed ID: 20456003
[TBL] [Abstract][Full Text] [Related]
19. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
20. MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins.
Tachi N; Hashimoto Y; Matsuoka M
Biochem J; 2012 Mar; 442(2):413-22. PubMed ID: 22115042
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
