201 related articles for article (PubMed ID: 22525366)
1. LRRK2 I2020T mutation is associated with tau pathology.
Ujiie S; Hatano T; Kubo S; Imai S; Sato S; Uchihara T; Yagishita S; Hasegawa K; Kowa H; Sakai F; Hattori N
Parkinsonism Relat Disord; 2012 Aug; 18(7):819-23. PubMed ID: 22525366
[TBL] [Abstract][Full Text] [Related]
2. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.
Ohta E; Nihira T; Uchino A; Imaizumi Y; Okada Y; Akamatsu W; Takahashi K; Hayakawa H; Nagai M; Ohyama M; Ryo M; Ogino M; Murayama S; Takashima A; Nishiyama K; Mizuno Y; Mochizuki H; Obata F; Okano H
Hum Mol Genet; 2015 Sep; 24(17):4879-900. PubMed ID: 26056228
[TBL] [Abstract][Full Text] [Related]
3. Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.
Ohta E; Kawakami F; Kubo M; Obata F
Biochem Biophys Res Commun; 2013 Jan; 430(2):560-6. PubMed ID: 23220480
[TBL] [Abstract][Full Text] [Related]
4. Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation.
Giordana MT; D'Agostino C; Albani G; Mauro A; Di Fonzo A; Antonini A; Bonifati V
Mov Disord; 2007 Jan; 22(2):275-8. PubMed ID: 17149743
[TBL] [Abstract][Full Text] [Related]
5. [Clinical molecular genetics for PARK8 (LRRK2)].
Tomiyama H; Hatano T; Hattori N
Brain Nerve; 2007 Aug; 59(8):839-50. PubMed ID: 17713120
[TBL] [Abstract][Full Text] [Related]
6. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Hamm M; Bailey R; Shaw G; Yen SH; Lewis J; Giasson BI
J Neurosci Res; 2015 Oct; 93(10):1567-80. PubMed ID: 26123245
[TBL] [Abstract][Full Text] [Related]
7. Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.
Kamikawaji S; Ito G; Sano T; Iwatsubo T
Biochemistry; 2013 Sep; 52(35):6052-62. PubMed ID: 23924436
[TBL] [Abstract][Full Text] [Related]
8. TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT.
Ling H; Kara E; Bandopadhyay R; Hardy J; Holton J; Xiromerisiou G; Lees A; Houlden H; Revesz T
Neurobiol Aging; 2013 Dec; 34(12):2889.e5-9. PubMed ID: 23664753
[TBL] [Abstract][Full Text] [Related]
9. Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Mikhail F; Calingasan N; Parolari L; Subramanian A; Yang L; Flint Beal M
Hum Mol Genet; 2015 Jun; 24(12):3545-56. PubMed ID: 25804954
[TBL] [Abstract][Full Text] [Related]
10. Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β.
Kawakami F; Shimada N; Ohta E; Kagiya G; Kawashima R; Maekawa T; Maruyama H; Ichikawa T
FEBS J; 2014 Jan; 281(1):3-13. PubMed ID: 24165324
[TBL] [Abstract][Full Text] [Related]
11. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
Tsika E; Nguyen AP; Dusonchet J; Colin P; Schneider BL; Moore DJ
Neurobiol Dis; 2015 May; 77():49-61. PubMed ID: 25731749
[TBL] [Abstract][Full Text] [Related]
12. Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.
Miklossy J; Qing H; Guo JP; Yu S; Wszolek ZK; Calne D; McGeer EG; McGeer PL
Acta Neuropathol; 2007 Sep; 114(3):243-54. PubMed ID: 17639429
[TBL] [Abstract][Full Text] [Related]
13. Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Ohta E; Kubo M; Obata F
Biochem Biophys Res Commun; 2010 Jan; 391(1):242-7. PubMed ID: 19912990
[TBL] [Abstract][Full Text] [Related]
14. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.
Gloeckner CJ; Kinkl N; Schumacher A; Braun RJ; O'Neill E; Meitinger T; Kolch W; Prokisch H; Ueffing M
Hum Mol Genet; 2006 Jan; 15(2):223-32. PubMed ID: 16321986
[TBL] [Abstract][Full Text] [Related]
15. LRRK2 and neurodegeneration.
Santpere G; Ferrer I
Acta Neuropathol; 2009 Mar; 117(3):227-46. PubMed ID: 19142648
[TBL] [Abstract][Full Text] [Related]
16. LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Shanley MR; Hawley D; Leung S; Zaidi NF; Dave R; Schlosser KA; Bandopadhyay R; Gerber SA; Liu M
Biochemistry; 2015 Aug; 54(33):5198-208. PubMed ID: 26268594
[TBL] [Abstract][Full Text] [Related]
17. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Perry G; Zhu X; Babar AK; Siedlak SL; Yang Q; Ito G; Iwatsubo T; Smith MA; Chen SG
Neurodegener Dis; 2008; 5(3-4):222-4. PubMed ID: 18322396
[TBL] [Abstract][Full Text] [Related]
18. Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.
Reichling LJ; Riddle SM
Biochem Biophys Res Commun; 2009 Jun; 384(2):255-8. PubMed ID: 19397894
[TBL] [Abstract][Full Text] [Related]
19. Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Henderson MX; Sengupta M; Trojanowski JQ; Lee VMY
Acta Neuropathol Commun; 2019 Nov; 7(1):183. PubMed ID: 31733655
[TBL] [Abstract][Full Text] [Related]
20. Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.
Devine MJ; Lewis PA
FEBS J; 2008 Dec; 275(23):5748-57. PubMed ID: 19021752
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]