BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 22534039)

  • 1. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
    Hata S; Taniguchi M; Piao Y; Ikeuchi T; Fagan AM; Holtzman DM; Bateman R; Sohrabi HR; Martins RN; Gandy S; Urakami K; Suzuki T;
    Mol Neurodegener; 2012 Apr; 7():16. PubMed ID: 22534039
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system.
    Konno T; Hata S; Hamada Y; Horikoshi-Sakuraba Y; Nakaya T; Saito Y; Yamamoto T; Yamamoto T; Maeda M; Ikeuchi T; Gandy S; Akatsu H; Suzuki T;
    Mol Neurodegener; 2011 Nov; 6():76. PubMed ID: 22067061
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.
    Omori C; Kaneko M; Nakajima E; Akatsu H; Waragai M; Maeda M; Morishima-Kawashima M; Saito Y; Nakaya T; Taru H; Yamamoto T; Asada T; Hata S; Suzuki T;
    J Alzheimers Dis; 2014; 39(4):861-70. PubMed ID: 24305499
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
    Hata S; Fujishige S; Araki Y; Taniguchi M; Urakami K; Peskind E; Akatsu H; Araseki M; Yamamoto K; Martins RN; Maeda M; Nishimura M; Levey A; Chung KA; Montine T; Leverenz J; Fagan A; Goate A; Bateman R; Holtzman DM; Yamamoto T; Nakaya T; Gandy S; Suzuki T
    Ann Neurol; 2011 Jun; 69(6):1026-31. PubMed ID: 21681798
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients.
    Olsson A; Höglund K; Sjögren M; Andreasen N; Minthon L; Lannfelt L; Buerger K; Möller HJ; Hampel H; Davidsson P; Blennow K
    Exp Neurol; 2003 Sep; 183(1):74-80. PubMed ID: 12957490
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Soluble BACE-1 Activity and sAβPPβ Concentrations in Alzheimer's Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer's Disease Neuroimaging Initiative-1 Baseline Cohort.
    Savage MJ; Holder DJ; Wu G; Kaplow J; Siuciak JA; Potter WZ;
    J Alzheimers Dis; 2015; 46(2):431-40. PubMed ID: 25790831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
    Siegel G; Gerber H; Koch P; Bruestle O; Fraering PC; Rajendran L
    Cell Rep; 2017 Jun; 19(10):1967-1976. PubMed ID: 28591569
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease.
    Kakuda N; Shoji M; Arai H; Furukawa K; Ikeuchi T; Akazawa K; Takami M; Hatsuta H; Murayama S; Hashimoto Y; Miyajima M; Arai H; Nagashima Y; Yamaguchi H; Kuwano R; Nagaike K; Ihara Y;
    EMBO Mol Med; 2012 Apr; 4(4):344-52. PubMed ID: 22354516
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.
    Takei N; Sobu Y; Kimura A; Urano S; Piao Y; Araki Y; Taru H; Yamamoto T; Hata S; Nakaya T; Suzuki T
    J Biol Chem; 2015 Jan; 290(2):987-95. PubMed ID: 25406318
    [TBL] [Abstract][Full Text] [Related]  

  • 10. γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.
    Liu F; Xue ZQ; Deng SH; Kun X; Luo XG; Patrylo PR; Rose GM; Cai H; Struble RG; Cai Y; Yan XX
    Eur J Neurosci; 2013 May; 37(10):1714-25. PubMed ID: 23432732
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Relationship between β-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease.
    Alcolea D; Carmona-Iragui M; Suárez-Calvet M; Sánchez-Saudinós MB; Sala I; Antón-Aguirre S; Blesa R; Clarimón J; Fortea J; Lleó A
    J Alzheimers Dis; 2014; 42(1):157-67. PubMed ID: 24820015
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease.
    Kamogawa K; Kohara K; Tabara Y; Takita R; Miki T; Konno T; Hata S; Suzuki T
    J Alzheimers Dis; 2012; 31(2):421-8. PubMed ID: 22571980
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in human cerebrospinal fluid.
    Gabelle A; Roche S; Gény C; Bennys K; Labauge P; Tholance Y; Quadrio I; Tiers L; Gor B; Chaulet C; Vighetto A; Croisile B; Krolak-Salmon P; Touchon J; Perret-Liaudet A; Lehmann S
    Brain Res; 2010 Oct; 1357():175-83. PubMed ID: 20713025
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cerebrospinal fluid profiles of amyloid β-related biomarkers in Alzheimer's disease.
    Rosén C; Andreasson U; Mattsson N; Marcusson J; Minthon L; Andreasen N; Blennow K; Zetterberg H
    Neuromolecular Med; 2012 Mar; 14(1):65-73. PubMed ID: 22350541
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
    Hata S; Fujishige S; Araki Y; Kato N; Araseki M; Nishimura M; Hartmann D; Saftig P; Fahrenholz F; Taniguchi M; Urakami K; Akatsu H; Martins RN; Yamamoto K; Maeda M; Yamamoto T; Nakaya T; Gandy S; Suzuki T
    J Biol Chem; 2009 Dec; 284(52):36024-36033. PubMed ID: 19864413
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
    Hock C; Golombowski S; Müller-Spahn F; Naser W; Beyreuther K; Mönning U; Schenk D; Vigo-Pelfrey C; Bush AM; Moir R; Tanzi RE; Growdon JH; Nitsch RM
    Eur Neurol; 1998; 39(2):111-8. PubMed ID: 9520072
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
    Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
    Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
    Dobrowolska JA; Michener MS; Wu G; Patterson BW; Chott R; Ovod V; Pyatkivskyy Y; Wildsmith KR; Kasten T; Mathers P; Dancho M; Lennox C; Smith BE; Gilberto D; McLoughlin D; Holder DJ; Stamford AW; Yarasheski KE; Kennedy ME; Savage MJ; Bateman RJ
    J Neurosci; 2014 Jun; 34(24):8336-46. PubMed ID: 24920637
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.
    Hampel H; Shen Y
    Scand J Clin Lab Invest; 2009; 69(1):8-12. PubMed ID: 18609117
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.
    Bekris LM; Galloway NM; Millard S; Lockhart D; Li G; Galasko DR; Farlow MR; Clark CM; Quinn JF; Kaye JA; Schellenberg GD; Leverenz JB; Seubert P; Tsuang DW; Peskind ER; Yu CE
    Neurobiol Aging; 2011 Mar; 32(3):556.e13-23. PubMed ID: 21196064
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.