BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 22540945)

  • 1. Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.
    Nakano H; Saito N; Parker L; Tada Y; Abe M; Tsuganezawa K; Yokoyama S; Tanaka A; Kojima H; Okabe T; Nagano T
    J Med Chem; 2012 Jun; 55(11):5151-64. PubMed ID: 22540945
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives.
    More KN; Jang HW; Hong VS; Lee J
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2424-8. PubMed ID: 24775304
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
    Hong S; Kim J; Seo JH; Jung KH; Hong SS; Hong S
    J Med Chem; 2012 Jun; 55(11):5337-49. PubMed ID: 22575050
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of quinones as novel PIM1 kinase inhibitors.
    Schroeder RL; Goyal N; Bratton M; Townley I; Pham NA; Tram P; Stone T; Geathers J; Nguyen K; Sridhar J
    Bioorg Med Chem Lett; 2016 Jul; 26(13):3187-3191. PubMed ID: 27173800
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
    Tao ZF; Hasvold LA; Leverson JD; Han EK; Guan R; Johnson EF; Stoll VS; Stewart KD; Stamper G; Soni N; Bouska JJ; Luo Y; Sowin TJ; Lin NH; Giranda VS; Rosenberg SH; Penning TD
    J Med Chem; 2009 Nov; 52(21):6621-36. PubMed ID: 19842661
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.
    More KN; Hong VS; Lee A; Park J; Kim S; Lee J
    Bioorg Med Chem Lett; 2018 Aug; 28(14):2513-2517. PubMed ID: 29871845
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases.
    Dao VH; Ourliac-Garnier I; Logé C; McCarthy FO; Bach S; da Silva TG; Denevault-Sabourin C; Thiéfaine J; Baratte B; Robert T; Gouilleux F; Brachet-Botineau M; Bazin MA; Marchand P
    Molecules; 2021 Oct; 26(21):. PubMed ID: 34770981
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1.
    Manjulatha K; Srinivas S; Mulakayala N; Rambabu D; Prabhakar M; Arunasree KM; Alvala M; Basaveswara Rao MV; Pal M
    Bioorg Med Chem Lett; 2012 Oct; 22(19):6160-5. PubMed ID: 22929231
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.
    Hou Z; Nakanishi I; Kinoshita T; Takei Y; Yasue M; Misu R; Suzuki Y; Nakamura S; Kure T; Ohno H; Murata K; Kitaura K; Hirasawa A; Tsujimoto G; Oishi S; Fujii N
    J Med Chem; 2012 Mar; 55(6):2899-903. PubMed ID: 22339433
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
    Barberis C; Moorcroft N; Arendt C; Levit M; Moreno-Mazza S; Batchelor J; Mechin I; Majid T
    Bioorg Med Chem Lett; 2017 Oct; 27(20):4730-4734. PubMed ID: 28947155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, antiproliferative activities and in vitro biological evaluation of novel benzofuransulfonamide derivatives.
    Yang L; Lei H; Mi CG; Liu H; Zhou T; Zhao YL; Lai XY; Li ZC; Song H; Huang WC
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5389-92. PubMed ID: 21795045
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.
    Adams ND; Adams JL; Burgess JL; Chaudhari AM; Copeland RA; Donatelli CA; Drewry DH; Fisher KE; Hamajima T; Hardwicke MA; Huffman WF; Koretke-Brown KK; Lai ZV; McDonald OB; Nakamura H; Newlander KA; Oleykowski CA; Parrish CA; Patrick DR; Plant R; Sarpong MA; Sasaki K; Schmidt SJ; Silva DJ; Sutton D; Tang J; Thompson CS; Tummino PJ; Wang JC; Xiang H; Yang J; Dhanak D
    J Med Chem; 2010 May; 53(10):3973-4001. PubMed ID: 20420387
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update.
    Arunesh GM; Shanthi E; Krishna MH; Sooriya Kumar J; Viswanadhan VN
    Expert Opin Ther Pat; 2014 Jan; 24(1):5-17. PubMed ID: 24131033
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regioselective synthesis and in vitro anticancer activity of 4-aza-podophyllotoxin derivatives catalyzed by L-proline.
    Shi C; Wang J; Chen H; Shi D
    J Comb Chem; 2010 Jul; 12(4):430-4. PubMed ID: 20503973
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model.
    Barberis C; Erdman P; Czekaj M; Fire L; Pribish J; Tserlin E; Maniar S; Batchelor JD; Liu J; Patel VF; Hebert A; Levit M; Wang A; Sun F; Huang SA
    Bioorg Med Chem Lett; 2020 Dec; 30(23):127625. PubMed ID: 33096160
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
    Mahboobi S; Sellmer A; Höcher H; Garhammer C; Pongratz H; Maier T; Ciossek T; Beckers T
    J Med Chem; 2007 Sep; 50(18):4405-18. PubMed ID: 17691763
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
    Matter H; Scheiper B; Steinhagen H; Böcskei Z; Fleury V; McCort G
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5487-92. PubMed ID: 21840215
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
    Xiang Y; Hirth B; Asmussen G; Biemann HP; Bishop KA; Good A; Fitzgerald M; Gladysheva T; Jain A; Jancsics K; Liu J; Metz M; Papoulis A; Skerlj R; Stepp JD; Wei RR
    Bioorg Med Chem Lett; 2011 May; 21(10):3050-6. PubMed ID: 21507633
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.
    Pogacic V; Bullock AN; Fedorov O; Filippakopoulos P; Gasser C; Biondi A; Meyer-Monard S; Knapp S; Schwaller J
    Cancer Res; 2007 Jul; 67(14):6916-24. PubMed ID: 17638903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
    Heald RA; Jackson P; Savy P; Jones M; Gancia E; Burton B; Newman R; Boggs J; Chan E; Chan J; Choo E; Merchant M; Rudewicz P; Ultsch M; Wiesmann C; Yue Q; Belvin M; Price S
    J Med Chem; 2012 May; 55(10):4594-604. PubMed ID: 22506516
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.