116 related articles for article (PubMed ID: 22549023)
1. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target.
Steverding D; Sexton DW; Wang X; Gehrke SS; Wagner GK; Caffrey CR
Int J Parasitol; 2012 May; 42(5):481-8. PubMed ID: 22549023
[TBL] [Abstract][Full Text] [Related]
2. Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms.
Steverding D; Rushworth SA; Florea BI; Overkleeft HS
Mol Biochem Parasitol; 2020 Jan; 235():111246. PubMed ID: 31743688
[TBL] [Abstract][Full Text] [Related]
3. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.
Mackey ZB; O'Brien TC; Greenbaum DC; Blank RB; McKerrow JH
J Biol Chem; 2004 Nov; 279(46):48426-33. PubMed ID: 15326171
[TBL] [Abstract][Full Text] [Related]
4. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.
Abdulla MH; O'Brien T; Mackey ZB; Sajid M; Grab DJ; McKerrow JH
PLoS Negl Trop Dis; 2008 Sep; 2(9):e298. PubMed ID: 18820745
[TBL] [Abstract][Full Text] [Related]
5. Processing and targeting of cathepsin L (TbCatL) to the lysosome in Trypanosoma brucei.
Koeller CM; Bangs JD
Cell Microbiol; 2019 Apr; 21(4):e12980. PubMed ID: 30427109
[TBL] [Abstract][Full Text] [Related]
6. Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei.
Steverding D; da Nóbrega FR; Rushworth SA; de Sousa DP
Parasitol Res; 2016 Nov; 115(11):4397-4403. PubMed ID: 27535679
[TBL] [Abstract][Full Text] [Related]
7. The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis.
Ettari R; Previti S; Tamborini L; Cullia G; Grasso S; Zappalà M
Mini Rev Med Chem; 2016; 16(17):1374-1391. PubMed ID: 27156518
[TBL] [Abstract][Full Text] [Related]
8. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
Mallari JP; Shelat AA; Obrien T; Caffrey CR; Kosinski A; Connelly M; Harbut M; Greenbaum D; McKerrow JH; Guy RK
J Med Chem; 2008 Feb; 51(3):545-52. PubMed ID: 18173229
[TBL] [Abstract][Full Text] [Related]
9. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.
Montaser M; Lalmanach G; Mach L
Biol Chem; 2002; 383(7-8):1305-8. PubMed ID: 12437121
[TBL] [Abstract][Full Text] [Related]
10. Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes.
Elliott EB; McCarroll D; Hasumi H; Welsh CE; Panissidi AA; Jones NG; Rossor CL; Tait A; Smith GL; Mottram JC; Morrison LJ; Loughrey CM
Cardiovasc Res; 2013 Nov; 100(2):325-35. PubMed ID: 23892734
[TBL] [Abstract][Full Text] [Related]
11. Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.
Alsford S; Currier RB; Guerra-Assunção JA; Clark TG; Horn D
PLoS Pathog; 2014 May; 10(5):e1004130. PubMed ID: 24830321
[TBL] [Abstract][Full Text] [Related]
12. Structure-guided development of selective TbcatB inhibitors.
Mallari JP; Shelat AA; Kosinski A; Caffrey CR; Connelly M; Zhu F; McKerrow JH; Guy RK
J Med Chem; 2009 Oct; 52(20):6489-93. PubMed ID: 19769357
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
14. Involvement of cathepsin B- and L-like proteinases in silk gland histolysis during metamorphosis of Bombyx mori.
Shiba H; Uchida D; Kobayashi H; Natori M
Arch Biochem Biophys; 2001 Jun; 390(1):28-34. PubMed ID: 11368511
[TBL] [Abstract][Full Text] [Related]
15. Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis.
Takahashi K; Ueno T; Tanida I; Minematsu-Ikeguchi N; Murata M; Kominami E
Biol Pharm Bull; 2009 Mar; 32(3):475-9. PubMed ID: 19252298
[TBL] [Abstract][Full Text] [Related]
16. Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity.
Kangethe RT; Boulangé AF; Coustou V; Baltz T; Coetzer TH
Mol Biochem Parasitol; 2012; 182(1-2):7-16. PubMed ID: 22123425
[TBL] [Abstract][Full Text] [Related]
17. A parasite cysteine protease is key to host protein degradation and iron acquisition.
O'Brien TC; Mackey ZB; Fetter RD; Choe Y; O'Donoghue AJ; Zhou M; Craik CS; Caffrey CR; McKerrow JH
J Biol Chem; 2008 Oct; 283(43):28934-43. PubMed ID: 18701454
[TBL] [Abstract][Full Text] [Related]
18. Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2.
Scory S; Caffrey CR; Stierhof YD; Ruppel A; Steverding D
Exp Parasitol; 1999 Apr; 91(4):327-33. PubMed ID: 10092476
[TBL] [Abstract][Full Text] [Related]
19. Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.
Mallari JP; Zhu F; Lemoff A; Kaiser M; Lu M; Brun R; Guy RK
Bioorg Med Chem; 2010 Dec; 18(23):8302-9. PubMed ID: 21051236
[TBL] [Abstract][Full Text] [Related]
20. Lysosomal and non-lysosomal peptidyl hydrolases of the bloodstream forms of Trypanosoma brucei brucei.
Lonsdale-Eccles JD; Grab DJ
Eur J Biochem; 1987 Dec; 169(3):467-75. PubMed ID: 3319612
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]