295 related articles for article (PubMed ID: 22551149)
1. Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
Hornick JR; Vangveravong S; Spitzer D; Abate C; Berardi F; Goedegebuure P; Mach RH; Hawkins WG
J Exp Clin Cancer Res; 2012 May; 31(1):41. PubMed ID: 22551149
[TBL] [Abstract][Full Text] [Related]
2. Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
Pati ML; Hornick JR; Niso M; Berardi F; Spitzer D; Abate C; Hawkins W
BMC Cancer; 2017 Jan; 17(1):51. PubMed ID: 28086830
[TBL] [Abstract][Full Text] [Related]
3. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.
Ostenfeld MS; Fehrenbacher N; Høyer-Hansen M; Thomsen C; Farkas T; Jäättelä M
Cancer Res; 2005 Oct; 65(19):8975-83. PubMed ID: 16204071
[TBL] [Abstract][Full Text] [Related]
4. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.
Hornick JR; Xu J; Vangveravong S; Tu Z; Mitchem JB; Spitzer D; Goedegebuure P; Mach RH; Hawkins WG
Mol Cancer; 2010 Nov; 9():298. PubMed ID: 21092190
[TBL] [Abstract][Full Text] [Related]
5. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.
Kashiwagi H; McDunn JE; Simon PO; Goedegebuure PS; Xu J; Jones L; Chang K; Johnston F; Trinkaus K; Hotchkiss RS; Mach RH; Hawkins WG
Mol Cancer; 2007 Jul; 6():48. PubMed ID: 17631687
[TBL] [Abstract][Full Text] [Related]
6. PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.
Yeung BH; Huang DC; Sinicrope FA
J Biol Chem; 2006 Apr; 281(17):11923-32. PubMed ID: 16446371
[TBL] [Abstract][Full Text] [Related]
7. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.
Hashim YM; Spitzer D; Vangveravong S; Hornick MC; Garg G; Hornick JR; Goedegebuure P; Mach RH; Hawkins WG
Mol Oncol; 2014 Jul; 8(5):956-67. PubMed ID: 24731702
[TBL] [Abstract][Full Text] [Related]
8. Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models.
Niso M; Kopecka J; Abatematteo FS; Berardi F; Riganti C; Abate C
Cell Oncol (Dordr); 2021 Dec; 44(6):1307-1323. PubMed ID: 34586588
[TBL] [Abstract][Full Text] [Related]
9. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.
Garg G; Vangveravong S; Zeng C; Collins L; Hornick M; Hashim Y; Piwnica-Worms D; Powell MA; Mutch DG; Mach RH; Hawkins WG; Spitzer D
Mol Cancer; 2014 Mar; 13():50. PubMed ID: 24602489
[TBL] [Abstract][Full Text] [Related]
10. SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation.
Ludwig JM; Gai Y; Sun L; Xiang G; Zeng D; Kim HS
Mol Oncol; 2016 Aug; 10(7):1133-45. PubMed ID: 27262893
[TBL] [Abstract][Full Text] [Related]
11. Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells.
McDonald ES; Mankoff J; Makvandi M; Chu W; Chu Y; Mach RH; Zeng C
Biochem Biophys Res Commun; 2017 May; 486(3):788-795. PubMed ID: 28347815
[TBL] [Abstract][Full Text] [Related]
12. Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.
Mediavilla-Varela M; Pacheco FJ; Almaguel F; Perez J; Sahakian E; Daniels TR; Leoh LS; Padilla A; Wall NR; Lilly MB; De Leon M; Casiano CA
Mol Cancer; 2009 Aug; 8():68. PubMed ID: 19715609
[TBL] [Abstract][Full Text] [Related]
13. Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells.
Chang SH; Lin PY; Wu TK; Hsu CS; Huang SW; Li ZY; Liu KT; Kao JK; Chen YJ; Wong TW; Wu CY; Shieh JJ
J Dermatol Sci; 2022 Sep; 107(3):142-150. PubMed ID: 36075780
[TBL] [Abstract][Full Text] [Related]
14. (-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.
Zhang Y; Yang ND; Zhou F; Shen T; Duan T; Zhou J; Shi Y; Zhu XQ; Shen HM
PLoS One; 2012; 7(10):e46749. PubMed ID: 23056433
[TBL] [Abstract][Full Text] [Related]
15. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer.
Zeng C; Vangveravong S; McDunn JE; Hawkins WG; Mach RH
Br J Cancer; 2013 Oct; 109(9):2368-77. PubMed ID: 24104966
[TBL] [Abstract][Full Text] [Related]
16. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
Česen MH; Repnik U; Turk V; Turk B
Cell Death Dis; 2013 Oct; 4(10):e818. PubMed ID: 24091661
[TBL] [Abstract][Full Text] [Related]
17. Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity.
Marino J; García Vior MC; Furmento VA; Blank VC; Awruch J; Roguin LP
Int J Biochem Cell Biol; 2013 Nov; 45(11):2553-62. PubMed ID: 23994488
[TBL] [Abstract][Full Text] [Related]
18. Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.
Venkatesan T; Choi YW; Mun SP; Kim YK
Cell Biol Toxicol; 2016 Oct; 32(5):451-64. PubMed ID: 27400986
[TBL] [Abstract][Full Text] [Related]
19. Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
Zeng C; Rothfuss J; Zhang J; Chu W; Vangveravong S; Tu Z; Pan F; Chang KC; Hotchkiss R; Mach RH
Br J Cancer; 2012 Feb; 106(4):693-701. PubMed ID: 22251921
[TBL] [Abstract][Full Text] [Related]
20. Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.
Oku Y; Murakami K; Irie K; Hoseki J; Sakai Y
Cell Struct Funct; 2017 May; 42(1):71-79. PubMed ID: 28413178
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]