BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 22560470)

  • 1. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
    Wang T; Duncan L; Gu W; O'Dowd H; Wei Y; Perola E; Parsons J; Gross CH; Moody CS; Arends SJ; Charifson PS
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3699-703. PubMed ID: 22560470
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
    Gu W; Wang T; Maltais F; Ledford B; Kennedy J; Wei Y; Gross CH; Parsons J; Duncan L; Arends SJ; Moody C; Perola E; Green J; Charifson PS
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3693-8. PubMed ID: 22560473
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity.
    Stokes SS; Huynh H; Gowravaram M; Albert R; Cavero-Tomas M; Chen B; Harang J; Loch JT; Lu M; Mullen GB; Zhao S; Liu CF; Mills SD
    Bioorg Med Chem Lett; 2011 Aug; 21(15):4556-60. PubMed ID: 21719282
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
    Murphy-Benenato KE; Gingipalli L; Boriack-Sjodin PA; Martinez-Botella G; Carcanague D; Eyermann CJ; Gowravaram M; Harang J; Hale MR; Ioannidis G; Jahic H; Johnstone M; Kutschke A; Laganas VA; Loch JT; Miller MD; Oguto H; Patel SJ
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5172-7. PubMed ID: 26463129
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of new 2-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their antibacterial activity.
    Lakshmi Narayana B; Ram Rao AR; Shanthan Rao P
    Eur J Med Chem; 2009 Mar; 44(3):1369-76. PubMed ID: 18603332
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
    Li Q; Chu DT; Claiborne A; Cooper CS; Lee CM; Raye K; Berst KB; Donner P; Wang W; Hasvold L; Fung A; Ma Z; Tufano M; Flamm R; Shen LL; Baranowski J; Nilius A; Alder J; Meulbroek J; Marsh K; Crowell D; Hui Y; Seif L; Melcher LM; Plattner JJ
    J Med Chem; 1996 Aug; 39(16):3070-88. PubMed ID: 8759628
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors.
    Lv PC; Wang KR; Yang Y; Mao WJ; Chen J; Xiong J; Zhu HL
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6750-4. PubMed ID: 19836235
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).
    Tomasić T; Zidar N; Sink R; Kovac A; Blanot D; Contreras-Martel C; Dessen A; Müller-Premru M; Zega A; Gobec S; Kikelj D; Masic LP
    J Med Chem; 2011 Jul; 54(13):4600-10. PubMed ID: 21591605
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
    Surivet JP; Lange R; Hubschwerlen C; Keck W; Specklin JL; Ritz D; Bur D; Locher H; Seiler P; Strasser DS; Prade L; Kohl C; Schmitt C; Chapoux G; Ilhan E; Ekambaram N; Athanasiou A; Knezevic A; Sabato D; Chambovey A; Gaertner M; Enderlin M; Boehme M; Sippel V; Wyss P
    Bioorg Med Chem Lett; 2012 Nov; 22(21):6705-11. PubMed ID: 23006603
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).
    Martínez-Botella G; Loch JT; Green OM; Kawatkar SP; Olivier NB; Boriack-Sjodin PA; Keating TA
    Bioorg Med Chem Lett; 2013 Jan; 23(1):169-73. PubMed ID: 23206863
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.
    Yadav N; Khanam T; Shukla A; Rai N; Hajela K; Ramachandran R
    Org Biomol Chem; 2015 May; 13(19):5475-87. PubMed ID: 25875403
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
    Kawatkar SP; Keating TA; Olivier NB; Breen JN; Green OM; Guler SY; Hentemann MF; Loch JT; McKenzie AR; Newman JV; Otterson LG; Martínez-Botella G
    J Med Chem; 2014 Jun; 57(11):4584-97. PubMed ID: 24828090
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.
    Xiao ZP; Wei W; Wang PF; Shi WK; Zhu N; Xie MQ; Sun YW; Li LX; Xie YX; Zhu LS; Tang N; Ouyang H; Li XH; Wang GC; Zhu HL
    Eur J Med Chem; 2015 Sep; 102():631-8. PubMed ID: 26318069
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and Optimization of NAD+-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds.
    Bi F; Ma R; Ma S
    Curr Pharm Des; 2017; 23(14):2117-2130. PubMed ID: 27784238
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
    Xiao ZP; Ouyang H; Wang XD; Lv PC; Huang ZJ; Yu SR; Yi TF; Yang YL; Zhu HL
    Bioorg Med Chem; 2011 Jul; 19(13):3884-91. PubMed ID: 21669535
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Toward the virtual screening of potential drugs in the homology modeled NAD+ dependent DNA ligase from Mycobacterium tuberculosis.
    Singh V; Somvanshi P
    Protein Pept Lett; 2010 Feb; 17(2):269-76. PubMed ID: 20214650
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design of a macrocyclic inhibitor for peptide deformylase.
    Hu X; Nguyen KT; Verlinde CL; Hol WG; Pei D
    J Med Chem; 2003 Aug; 46(18):3771-4. PubMed ID: 12930137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.
    Montgomery JI; Smith JF; Tomaras AP; Zaniewski R; McPherson CJ; McAllister LA; Hartman-Neumann S; Arcari JT; Lescoe M; Gutierrez J; Yuan Y; Limberakis C; Miller AA
    J Antibiot (Tokyo); 2015 Jun; 68(6):361-7. PubMed ID: 25464974
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one schiff bases.
    Narender M; Jaswanth S B; Umasankar K; Malathi J; Raghuram Reddy A; Umadevi KR; Dusthackeer AVN; Venkat Rao K; Raghuram R A
    Bioorg Med Chem Lett; 2016 Feb; 26(3):836-840. PubMed ID: 26755393
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism.
    Cui SF; Addla D; Zhou CH
    J Med Chem; 2016 May; 59(10):4488-510. PubMed ID: 27115717
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.