BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

71 related articles for article (PubMed ID: 22574973)

  • 1. Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.
    Bissantz C; Bohnert C; Hoffmann T; Marcuz A; Schnider P; Malherbe P
    J Med Chem; 2012 Jun; 55(11):5061-76. PubMed ID: 22574973
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.
    Blaney FE; Raveglia LF; Artico M; Cavagnera S; Dartois C; Farina C; Grugni M; Gagliardi S; Luttmann MA; Martinelli M; Nadler GM; Parini C; Petrillo P; Sarau HM; Scheideler MA; Hay DW; Giardina GA
    J Med Chem; 2001 May; 44(11):1675-89. PubMed ID: 11356103
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.
    Malherbe P; Kratzeisen C; Marcuz A; Zenner MT; Nettekoven MH; Ratni H; Wettstein JG; Bissantz C
    J Med Chem; 2009 Nov; 52(22):7103-12. PubMed ID: 19817444
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of novel NK1/NK3 dual antagonists for the potential treatment of schizophrenia.
    Catalani MP; Alvaro G; Bernasconi G; Bettini E; Bromidge SM; Heer J; Tedesco G; Tommasi S
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6899-904. PubMed ID: 21974957
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors.
    Engberg S; Ahlstedt I; Leffler A; Lindström E; Kristensson E; Svensson A; Påhlman I; Johansson A; Drmota T; von Mentzer B
    Biochem Pharmacol; 2007 Jan; 73(2):259-69. PubMed ID: 17097619
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).
    Giardina GA; Raveglia LF; Grugni M; Sarau HM; Farina C; Medhurst AD; Graziani D; Schmidt DB; Rigolio R; Luttmann M; Cavagnera S; Foley JJ; Vecchietti V; Hay DW
    J Med Chem; 1999 Mar; 42(6):1053-65. PubMed ID: 10090788
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of the rhesus monkey.
    Nagano M; Saitow F; Haneda E; Konishi S; Hayashi M; Suzuki H
    Br J Pharmacol; 2006 Feb; 147(3):316-23. PubMed ID: 16331282
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors.
    Malherbe P; Knoflach F; Hernandez MC; Hoffmann T; Schnider P; Porter RH; Wettstein JG; Ballard TM; Spooren W; Steward L
    Br J Pharmacol; 2011 Feb; 162(4):929-46. PubMed ID: 21039418
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacology of MEN 11467: a potent new selective and orally- effective peptidomimetic tachykinin NK(1) receptor antagonist.
    Cirillo R; Astolfi M; Conte B; Lopez G; Parlani M; Sacco G; Terracciano R; Fincham CI; Sisto A; Evangelista S; Maggi CA; Manzini S
    Neuropeptides; 2001; 35(3-4):137-47. PubMed ID: 11884203
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
    Malherbe P; Knoflach F; Marcuz A; Bohnert C; Weber M; Knust H; Ratni H; Spooren W; Ballard TM; Bissantz C
    Neuropharmacology; 2014 Nov; 86():259-72. PubMed ID: 25107588
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
    Sarau HM; Griswold DE; Bush B; Potts W; Sandhu P; Lundberg D; Foley JJ; Schmidt DB; Webb EF; Martin LD; Legos JJ; Whitmore RG; Barone FC; Medhurst AD; Luttmann MA; Giardina GA; Hay DW
    J Pharmacol Exp Ther; 2000 Oct; 295(1):373-81. PubMed ID: 10992004
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.
    Giardina GA; Sarau HM; Farina C; Medhurst AD; Grugni M; Raveglia LF; Schmidt DB; Rigolio R; Luttmann M; Vecchietti V; Hay DW
    J Med Chem; 1997 Jun; 40(12):1794-807. PubMed ID: 9191956
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3.
    Leffler A; Ahlstedt I; Engberg S; Svensson A; Billger M; Oberg L; Bjursell MK; Lindström E; von Mentzer B
    Biochem Pharmacol; 2009 May; 77(9):1522-30. PubMed ID: 19426690
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evidence that the proposed novel human "neurokinin-4" receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin.
    Sarau HM; Mooney JL; Schmidt DB; Foley JJ; Buckley PT; Giardina GA; Wang DY; Lee JA; Hay DW
    Mol Pharmacol; 2000 Sep; 58(3):552-9. PubMed ID: 10953048
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
    Tsuchida H; Takahashi S; Nosaka E; Mukaiyama O; Yamashita M; Morimoto K
    Eur J Pharmacol; 2008 May; 586(1-3):306-12. PubMed ID: 18353309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands.
    Peters JU; Hoffmann T; Schnider P; Stadler H; Koblet A; Alker A; Poli SM; Ballard TM; Spooren W; Steward L; Sleight AJ
    Bioorg Med Chem Lett; 2010 Jun; 20(11):3405-8. PubMed ID: 20430616
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
    Sundqvist M; Kristensson E; Adolfsson R; Leffler A; Ahlstedt I; Engberg S; Drmota T; Sigfridsson K; Jussila R; de Verdier J; Novén A; Johansson A; Påhlman I; von Mentzer B; Lindström E
    Eur J Pharmacol; 2007 Dec; 577(1-3):78-86. PubMed ID: 17920583
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Human NK inhibitory and activating receptors that bind to human leukocyte antigens (HLA) regulate NK cells and T cells].
    Ikeda H; Coulie PG
    Tanpakushitsu Kakusan Koso; 1997 Nov; 42(15):2510-21. PubMed ID: 9391340
    [No Abstract]   [Full Text] [Related]  

  • 19. Modification of the potent peptide FK888 with unusual aminoacids: effects on activity on neurokinin receptors.
    Caliendo G; Greco G; Grieco P; Perissutti E; Santagada V; Calignano A; Mancuso F; Novellino E
    Farmaco; 1996 Mar; 51(3):197-201. PubMed ID: 8688142
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular modeling of neurokinin B and tachykinin NK₃ receptor complex.
    Ganjiwale AD; Rao GS; Cowsik SM
    J Chem Inf Model; 2011 Nov; 51(11):2932-8. PubMed ID: 21913652
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.