89 related articles for article (PubMed ID: 22578458)
1. Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Chu L; Armstrong HM; Chang LL; Cheng AF; Colwell L; Cui J; Evans J; Galka A; Goulet MT; Hayes N; Lo J; Menke J; Ok HO; Ondeyka DL; Patel M; Quaker GM; Sings H; Witkin SL; Zhao A; Ujjainwalla F
Bioorg Med Chem Lett; 2012 Jun; 22(12):4133-8. PubMed ID: 22578458
[TBL] [Abstract][Full Text] [Related]
2. 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).
Banoglu E; Çelikoğlu E; Völker S; Olgaç A; Gerstmeier J; Garscha U; Çalışkan B; Schubert US; Carotti A; Macchiarulo A; Werz O
Eur J Med Chem; 2016 May; 113():1-10. PubMed ID: 26922224
[TBL] [Abstract][Full Text] [Related]
3. Structure-based drug design on membrane protein targets: human integral membrane protein 5-lipoxygenase-activating protein.
Ferguson AD
Methods Mol Biol; 2012; 841():267-90. PubMed ID: 22222457
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
Levent S; Gerstmeier J; Olgaç A; Nikels F; Garscha U; Carotti A; Macchiarulo A; Werz O; Banoglu E; Çalışkan B
Eur J Med Chem; 2016 Oct; 122():510-519. PubMed ID: 27423639
[TBL] [Abstract][Full Text] [Related]
5. Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.
De Simone R; Chini MG; Bruno I; Riccio R; Mueller D; Werz O; Bifulco G
J Med Chem; 2011 Mar; 54(6):1565-75. PubMed ID: 21323313
[TBL] [Abstract][Full Text] [Related]
6. Discovery and optimization of oxadiazole-based FLAP inhibitors.
Bartolozzi A; Abeywardane A; Bosanac T; Broadwater JA; Chen Z; Hutzler JM; Huber JD; Nemoto P; Olague A; Riether D; Simpson T; Takahashi H; Wu L; Zhang Y; Zindell RM
Bioorg Med Chem Lett; 2017 Oct; 27(20):4652-4659. PubMed ID: 28927794
[TBL] [Abstract][Full Text] [Related]
7. Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Banoglu E; Çalişkan B; Luderer S; Eren G; Özkan Y; Altenhofen W; Weinigel C; Barz D; Gerstmeier J; Pergola C; Werz O
Bioorg Med Chem; 2012 Jun; 20(12):3728-41. PubMed ID: 22607880
[TBL] [Abstract][Full Text] [Related]
8. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Stock NS; Bain G; Zunic J; Li Y; Ziff J; Roppe J; Santini A; Darlington J; Prodanovich P; King CD; Baccei C; Lee C; Rong H; Chapman C; Broadhead A; Lorrain D; Correa L; Hutchinson JH; Evans JF; Prasit P
J Med Chem; 2011 Dec; 54(23):8013-29. PubMed ID: 22059882
[TBL] [Abstract][Full Text] [Related]
9. Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
Lemurell M; Ulander J; Winiwarter S; Dahlén A; Davidsson Ö; Emtenäs H; Broddefalk J; Swanson M; Hovdal D; Plowright AT; Pettersen A; Rydén-Landergren M; Barlind J; Llinas A; Herslöf M; Drmota T; Sigfridsson K; Moses S; Whatling C
J Med Chem; 2015 Jan; 58(2):897-911. PubMed ID: 25478788
[TBL] [Abstract][Full Text] [Related]
10. Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.
Macdonald D; Brideau C; Chan CC; Falgueyret JP; Frenette R; Guay J; Hutchinson JH; Perrier H; Prasit P; Riendeau D; Tagari P; Thérien M; Young RN; Girard Y
Bioorg Med Chem Lett; 2008 Mar; 18(6):2023-7. PubMed ID: 18276139
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of [(3) H] and [(2) H6 ]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP).
Lindelöf Å; Ericsson C; Simonsson R; Nilsson G; Grönberg G; Elmore CS
J Labelled Comp Radiopharm; 2016 Jul; 59(9):340-5. PubMed ID: 27298225
[TBL] [Abstract][Full Text] [Related]
12. A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
Blevitt JM; Hack MD; Herman K; Chang L; Keith JM; Mirzadegan T; Rao NL; Lebsack AD; Milla ME
J Biol Chem; 2016 Jun; 291(24):12724-12731. PubMed ID: 27129215
[TBL] [Abstract][Full Text] [Related]
13. Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 1: SAR of the aryl region.
Levy DE; Wang DX; Lu Q; Chen Z; Perumattam J; Xu YJ; Liclican A; Higaki J; Dong H; Laney M; Mavunkel B; Dugar S
Bioorg Med Chem Lett; 2008 Apr; 18(7):2390-4. PubMed ID: 18334294
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and SAR comparative studies of 2-allyl-4-methoxy-1-alkoxybenzenes as 15-lipoxygenase inhibitors.
Sadeghian H; Seyedi SM; Attaran N; Jabbari A; Jafari Z
J Enzyme Inhib Med Chem; 2011 Apr; 26(2):238-44. PubMed ID: 20939767
[TBL] [Abstract][Full Text] [Related]
15. Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor.
Ericsson H; Nelander K; Lagerstrom-Fermer M; Balendran C; Bhat M; Chialda L; Gan LM; Heijer M; Kjaer M; Lambert J; Lindstedt EL; Forsberg GB; Whatling C; Skrtic S
Clin Transl Sci; 2018 May; 11(3):330-338. PubMed ID: 29517132
[TBL] [Abstract][Full Text] [Related]
16. [Synthesis and progestional activity of 7- -alkylthio-and 7- -arylthio-17- -acetoxyprogesterones].
Yamato Y; Masuda Y; Kaneko H
Yakugaku Zasshi; 1971 Jul; 91(7):770-2. PubMed ID: 5105482
[No Abstract] [Full Text] [Related]
17. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Sawyer JS; Anderson BD; Beight DW; Campbell RM; Jones ML; Herron DK; Lampe JW; McCowan JR; McMillen WT; Mort N; Parsons S; Smith EC; Vieth M; Weir LC; Yan L; Zhang F; Yingling JM
J Med Chem; 2003 Sep; 46(19):3953-6. PubMed ID: 12954047
[TBL] [Abstract][Full Text] [Related]
18. A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.
Uddin MJ; Praveen Rao PN; McDonald R; Knaus EE
J Med Chem; 2004 Nov; 47(24):6108-11. PubMed ID: 15537365
[TBL] [Abstract][Full Text] [Related]
19. Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Levy DE; Wang DX; Lu Q; Chen Z; Perumattam J; Xu YJ; Higaki J; Dong H; Liclican A; Laney M; Mavunkel B; Dugar S
Bioorg Med Chem Lett; 2008 Apr; 18(7):2395-8. PubMed ID: 18334295
[TBL] [Abstract][Full Text] [Related]
20. Rhodium-catalyzed reductive cleavage of carbon-cyano bonds with hydrosilane: a catalytic protocol for removal of cyano groups.
Tobisu M; Nakamura R; Kita Y; Chatani N
J Am Chem Soc; 2009 Mar; 131(9):3174-5. PubMed ID: 19215138
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]