BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 22578786)

  • 1. Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.
    Jasper A; Schepmann D; Lehmkuhl K; Vela JM; Buschmann H; Holenz J; Wünsch B
    Eur J Med Chem; 2012 Jul; 53():327-36. PubMed ID: 22578786
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.
    Jasper A; Schepmann D; Lehmkuhl K; Vela JM; Buschmann H; Holenz J; Wünsch B
    Eur J Med Chem; 2009 Nov; 44(11):4306-14. PubMed ID: 19709783
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis and pharmacological evaluation of spirocyclic σ(1) receptor ligands with exocyclic amino moiety (increased distance 1).
    Rack E; Fröhlich R; Schepmann D; Wünsch B
    Bioorg Med Chem; 2011 May; 19(10):3141-51. PubMed ID: 21531141
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].
    Oberdorf C; Schepmann D; Vela JM; Diaz JL; Holenz J; Wünsch B
    J Med Chem; 2008 Oct; 51(20):6531-7. PubMed ID: 18816044
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.
    Oberdorf C; Schepmann D; Vela JM; Buschmann H; Holenz J; Wünsch B
    J Med Chem; 2012 Jun; 55(11):5350-60. PubMed ID: 22515405
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyridine analogues of spirocyclic σ₁ receptor ligands.
    Miyata K; Möller G; Schepmann D; Wünsch B
    Bioorg Med Chem; 2014 Aug; 22(15):4277-84. PubMed ID: 24913984
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and σ receptor affinity of regioisomeric spirocyclic furopyridines.
    Miyata K; Schepmann D; Wünsch B
    Eur J Med Chem; 2014 Aug; 83():709-16. PubMed ID: 25016157
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability.
    Grosse Maestrup E; Wiese C; Schepmann D; Hiller A; Fischer S; Scheunemann M; Brust P; Wünsch B
    Bioorg Med Chem; 2009 May; 17(10):3630-41. PubMed ID: 19394833
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
    Banister SD; Rendina LM; Kassiou M
    Bioorg Med Chem Lett; 2012 Jun; 22(12):4059-63. PubMed ID: 22607684
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ(1) receptor ligands with a (2-fluoroethyl) residue in 3-position.
    Maestrup EG; Wiese C; Schepmann D; Brust P; Wünsch B
    Bioorg Med Chem; 2011 Jan; 19(1):393-405. PubMed ID: 21126878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.
    Schläger T; Schepmann D; Würthwein EU; Wünsch B
    Bioorg Med Chem; 2008 Mar; 16(6):2992-3001. PubMed ID: 18221879
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxa-Pictet-Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure.
    Knappmann I; Schepmann D; Wünsch B
    Bioorg Med Chem; 2016 Sep; 24(18):4045-4055. PubMed ID: 27396684
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.
    Maier CA; Wünsch B
    J Med Chem; 2002 Jan; 45(2):438-48. PubMed ID: 11784148
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].
    Wiese C; Grosse Maestrup E; Schepmann D; Vela JM; Holenz J; Buschmann H; Wünsch B
    J Pharm Pharmacol; 2009 May; 61(5):631-40. PubMed ID: 19406002
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.
    Maier CA; Wünsch B
    J Med Chem; 2002 Oct; 45(22):4923-30. PubMed ID: 12383018
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.
    de Costa BR; He XS; Dominguez C; Cutts J; Williams W; Bowen WD
    J Med Chem; 1994 Jan; 37(2):314-21. PubMed ID: 8295220
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging.
    Li Y; Wang X; Zhang J; Deuther-Conrad W; Xie F; Zhang X; Liu J; Qiao J; Cui M; Steinbach J; Brust P; Liu B; Jia H
    J Med Chem; 2013 May; 56(9):3478-91. PubMed ID: 23566245
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
    Peddi S; Roth BL; Glennon RA; Westkaemper RB
    Bioorg Med Chem Lett; 2004 May; 14(9):2279-83. PubMed ID: 15081025
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exploitation of an additional hydrophobic pocket of σ1 receptors: late-stage diverse modifications of spirocyclic thiophenes by C-H bond functionalization.
    Meyer C; Neue B; Schepmann D; Yanagisawa S; Yamaguchi J; Würthwein EU; Itami K; Wünsch B
    Org Biomol Chem; 2011 Dec; 9(23):8016-29. PubMed ID: 21986584
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling.
    Oberdorf C; Schmidt TJ; Wünsch B
    Eur J Med Chem; 2010 Jul; 45(7):3116-24. PubMed ID: 20427100
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.