176 related articles for article (PubMed ID: 22579485)
1. Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Keck GE; Poudel YB; Rudra A; Stephens JC; Kedei N; Lewin NE; Blumberg PM
Bioorg Med Chem Lett; 2012 Jun; 22(12):4084-8. PubMed ID: 22579485
[TBL] [Abstract][Full Text] [Related]
2. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Mackanos EA; Pettit GR; Ramsdell JS
J Biol Chem; 1991 Jun; 266(17):11205-12. PubMed ID: 1904062
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.
Andrews IP; Ketcham JM; Blumberg PM; Kedei N; Lewin NE; Peach ML; Krische MJ
J Am Chem Soc; 2014 Sep; 136(38):13209-16. PubMed ID: 25207655
[TBL] [Abstract][Full Text] [Related]
4. The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.
Wender PA; Verma VA
Org Lett; 2008 Aug; 10(15):3331-4. PubMed ID: 18588309
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
Irie K; Yanagita RC
Chem Rec; 2014 Apr; 14(2):251-67. PubMed ID: 24677503
[TBL] [Abstract][Full Text] [Related]
6. The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
Keck GE; Li W; Kraft MB; Kedei N; Lewin NE; Blumberg PM
Org Lett; 2009 Jun; 11(11):2277-80. PubMed ID: 19419164
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.
Kraft MB; Poudel YB; Kedei N; Lewin NE; Peach ML; Blumberg PM; Keck GE
J Am Chem Soc; 2014 Sep; 136(38):13202-8. PubMed ID: 25207434
[TBL] [Abstract][Full Text] [Related]
8. The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
Stanwell C; Gescher A; Bradshaw TD; Pettit GR
Int J Cancer; 1994 Feb; 56(4):585-92. PubMed ID: 8112895
[TBL] [Abstract][Full Text] [Related]
9. Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
Keck GE; Poudel YB; Welch DS; Kraft MB; Truong AP; Stephens JC; Kedei N; Lewin NE; Blumberg PM
Org Lett; 2009 Feb; 11(3):593-6. PubMed ID: 19113896
[TBL] [Abstract][Full Text] [Related]
10. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N; Lewin NE; Géczy T; Selezneva J; Braun DC; Chen J; Herrmann MA; Heldman MR; Lim L; Mannan P; Garfield SH; Poudel YB; Cummins TJ; Rudra A; Blumberg PM; Keck GE
ACS Chem Biol; 2013 Apr; 8(4):767-77. PubMed ID: 23369356
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring.
Baumann DO; McGowan KM; Kedei N; Peach ML; Blumberg PM; Keck GE
J Org Chem; 2016 Sep; 81(17):7862-83. PubMed ID: 27494208
[TBL] [Abstract][Full Text] [Related]
12. Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Szallasi Z; Denning MF; Smith CB; Dlugosz AA; Yuspa SH; Pettit GR; Blumberg PM
Mol Pharmacol; 1994 Nov; 46(5):840-50. PubMed ID: 7969070
[TBL] [Abstract][Full Text] [Related]
13. Protein kinase C-alpha but not protein kinase C-epsilon is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells.
Jalava A; Lintunen M; Heikkilä J
Biochem Biophys Res Commun; 1993 Mar; 191(2):472-8. PubMed ID: 8461005
[TBL] [Abstract][Full Text] [Related]
14. Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Kedei N; Telek A; Michalowski AM; Kraft MB; Li W; Poudel YB; Rudra A; Petersen ME; Keck GE; Blumberg PM
Biochem Pharmacol; 2013 Feb; 85(3):313-24. PubMed ID: 23146662
[TBL] [Abstract][Full Text] [Related]
15. The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Kedei N; Telek A; Czap A; Lubart ES; Czifra G; Yang D; Chen J; Morrison T; Goldsmith PK; Lim L; Mannan P; Garfield SH; Kraft MB; Li W; Keck GE; Blumberg PM
Biochem Pharmacol; 2011 Jun; 81(11):1296-308. PubMed ID: 21458422
[TBL] [Abstract][Full Text] [Related]
16. Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1.
Basu A; Lazo JS
Cancer Res; 1992 Jun; 52(11):3119-24. PubMed ID: 1591725
[TBL] [Abstract][Full Text] [Related]
17. Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.
Trost BM; Dong G
J Am Chem Soc; 2010 Nov; 132(46):16403-16. PubMed ID: 21043491
[TBL] [Abstract][Full Text] [Related]
18. Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.
Keck GE; Poudel YB; Rudra A; Stephens JC; Kedei N; Lewin NE; Peach ML; Blumberg PM
Angew Chem Int Ed Engl; 2010 Jun; 49(27):4580-4. PubMed ID: 20491108
[No Abstract] [Full Text] [Related]
19. Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
von Burstin VA; Xiao L; Kazanietz MG
Mol Pharmacol; 2010 Sep; 78(3):325-32. PubMed ID: 20516369
[TBL] [Abstract][Full Text] [Related]
20. Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin.
Lee HW; Smith L; Pettit GR; Bingham Smith J
Am J Physiol; 1996 Jul; 271(1 Pt 1):C304-11. PubMed ID: 8760059
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]