These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 22582065)

  • 1. Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.
    Chen D; Zhang Q; Zhang Q; Cen P; Xu Z; Liu W
    Appl Environ Microbiol; 2012 Aug; 78(15):5093-103. PubMed ID: 22582065
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Origin of the allyl group in FK506 biosynthesis.
    Goranovic D; Kosec G; Mrak P; Fujs S; Horvat J; Kuscer E; Kopitar G; Petkovic H
    J Biol Chem; 2010 May; 285(19):14292-300. PubMed ID: 20194504
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.
    Blažič M; Kosec G; Baebler Š; Gruden K; Petković H
    Microb Cell Fact; 2015 Oct; 14():164. PubMed ID: 26466669
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.
    Mo S; Lee SK; Jin YY; Suh JW
    J Microbiol Biotechnol; 2016 Feb; 26(2):233-40. PubMed ID: 26502733
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
    Mo S; Kim DH; Lee JH; Park JW; Basnet DB; Ban YH; Yoo YJ; Chen SW; Park SR; Choi EA; Kim E; Jin YY; Lee SK; Park JY; Liu Y; Lee MO; Lee KS; Kim SJ; Kim D; Park BC; Lee SG; Kwon HJ; Suh JW; Moore BS; Lim SK; Yoon YJ
    J Am Chem Soc; 2011 Feb; 133(4):976-85. PubMed ID: 21175203
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
    Wu K; Chung L; Revill WP; Katz L; Reeves CD
    Gene; 2000 Jun; 251(1):81-90. PubMed ID: 10863099
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
    Barreiro C; Prieto C; Sola-Landa A; Solera E; Martínez-Castro M; Pérez-Redondo R; García-Estrada C; Aparicio JF; Fernández-Martínez LT; Santos-Aberturas J; Salehi-Najafabadi Z; Rodríguez-García A; Tauch A; Martín JF
    J Bacteriol; 2012 Jul; 194(14):3756-7. PubMed ID: 22740677
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.
    Huang D; Xia M; Li S; Wen J; Jia X
    J Ind Microbiol Biotechnol; 2013 Sep; 40(9):1023-37. PubMed ID: 23779221
    [TBL] [Abstract][Full Text] [Related]  

  • 9. FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.
    Goranovič D; Blažič M; Magdevska V; Horvat J; Kuščer E; Polak T; Santos-Aberturas J; Martínez-Castro M; Barreiro C; Mrak P; Kopitar G; Kosec G; Fujs S; Martín JF; Petković H
    BMC Microbiol; 2012 Oct; 12():238. PubMed ID: 23083511
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.
    Zhang XS; Luo HD; Tao Y; Wang YY; Jiang XH; Jiang H; Li YQ
    J Ind Microbiol Biotechnol; 2016 Dec; 43(12):1693-1703. PubMed ID: 27757551
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.
    Ordóñez-Robles M; Rodríguez-García A; Martín JF
    Appl Microbiol Biotechnol; 2016 Sep; 100(18):8091-103. PubMed ID: 27357227
    [TBL] [Abstract][Full Text] [Related]  

  • 12. An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units.
    Jiang H; Wang YY; Guo YY; Shen JJ; Zhang XS; Luo HD; Ren NN; Jiang XH; Li YQ
    FEBS J; 2015 Jul; 282(13):2527-39. PubMed ID: 25865045
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor.
    Mo S; Ban YH; Park JW; Yoo YJ; Yoon YJ
    J Ind Microbiol Biotechnol; 2009 Dec; 36(12):1473-82. PubMed ID: 19756799
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011.
    Mo S; Lee SK; Jin YY; Oh CH; Suh JW
    Appl Microbiol Biotechnol; 2013 Apr; 97(7):3053-62. PubMed ID: 23053074
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel chemobiosynthetic approach for exclusive production of FK506.
    Kosec G; Goranovič D; Mrak P; Fujs S; Kuščer E; Horvat J; Kopitar G; Petković H
    Metab Eng; 2012 Jan; 14(1):39-46. PubMed ID: 22100790
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis.
    Wu QB; Zhang XY; Chen XA; Li YQ
    Microb Cell Fact; 2021 Aug; 20(1):166. PubMed ID: 34425854
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).
    Barreiro C; Martínez-Castro M
    Appl Microbiol Biotechnol; 2014 Jan; 98(2):497-507. PubMed ID: 24272367
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil.
    Wang J; Liu H; Huang D; Jin L; Wang C; Wen J
    Appl Microbiol Biotechnol; 2017 Mar; 101(6):2447-2465. PubMed ID: 28175948
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.
    Motamedi H; Shafiee A
    Eur J Biochem; 1998 Sep; 256(3):528-34. PubMed ID: 9780228
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase.
    Wang YY; Bai LF; Ran XX; Jiang XH; Wu H; Zhang W; Jin MY; Li YQ; Jiang H
    Protein Pept Lett; 2015; 22(1):2-7. PubMed ID: 25267255
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.