These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 22595961)

  • 1. Rescue of misrouted GnRHR mutants reveals its constitutive activity.
    Janovick JA; Pogozheva ID; Mosberg HI; Cornea A; Conn PM
    Mol Endocrinol; 2012 Jul; 26(7):1179-88. PubMed ID: 22595961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking.
    Janovick JA; Conn PM
    Methods Enzymol; 2010; 485():277-92. PubMed ID: 21050923
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect.
    Brothers SP; Cornea A; Janovick JA; Conn PM
    Mol Endocrinol; 2004 Jul; 18(7):1787-97. PubMed ID: 15105440
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.
    Janovick JA; Patny A; Mosley R; Goulet MT; Altman MD; Rush TS; Cornea A; Conn PM
    Mol Endocrinol; 2009 Feb; 23(2):157-68. PubMed ID: 19095769
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans.
    Leaños-Miranda A; Ulloa-Aguirre A; Ji TH; Janovick JA; Conn PM
    J Clin Endocrinol Metab; 2003 Jul; 88(7):3360-7. PubMed ID: 12843188
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.
    Maya-Núñez G; Janovick JA; Ulloa-Aguirre A; Söderlund D; Conn PM; Méndez JP
    J Clin Endocrinol Metab; 2002 May; 87(5):2144-9. PubMed ID: 11994356
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system.
    Cabrera-Wrooman A; Janovick JA; Conn PM
    Mol Cell Endocrinol; 2013 Dec; 381(1-2):1-7. PubMed ID: 23891857
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs.
    Janovick JA; Park BS; Conn PM
    PLoS One; 2011; 6(7):e22784. PubMed ID: 21818389
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy.
    Janovick JA; Knollman PE; Brothers SP; Ayala-Yáñez R; Aziz AS; Conn PM
    J Biol Chem; 2006 Mar; 281(13):8417-25. PubMed ID: 16446355
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants.
    Knollman PE; Janovick JA; Brothers SP; Conn PM
    J Biol Chem; 2005 Jul; 280(26):24506-14. PubMed ID: 15886197
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane.
    Lucca-Junior W; Janovick JA; Conn PM
    Braz J Med Biol Res; 2009 Feb; 42(2):164-7. PubMed ID: 19274343
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro.
    Janovick JA; Brothers SP; Cornea A; Bush E; Goulet MT; Ashton WT; Sauer DR; Haviv F; Greer J; Conn PM
    Mol Cell Endocrinol; 2007 Jun; 272(1-2):77-85. PubMed ID: 17555869
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.
    Conn PM; Ulloa-Aguirre A
    Trends Endocrinol Metab; 2010 Mar; 21(3):190-7. PubMed ID: 20005736
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor.
    Kosugi T; Sower SA
    Gen Comp Endocrinol; 2010 May; 166(3):498-503. PubMed ID: 20005226
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism.
    Leaños-Miranda A; Janovick JA; Conn PM
    J Clin Endocrinol Metab; 2002 Oct; 87(10):4825-8. PubMed ID: 12364481
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling.
    Tello JA; Newton CL; Bouligand J; Guiochon-Mantel A; Millar RP; Young J
    PLoS One; 2012; 7(6):e38456. PubMed ID: 22679506
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.
    Janovick JA; Stewart MD; Jacob D; Martin LD; Deng JM; Stewart CA; Wang Y; Cornea A; Chavali L; Lopez S; Mitalipov S; Kang E; Lee HS; Manna PR; Stocco DM; Behringer RR; Conn PM
    Proc Natl Acad Sci U S A; 2013 Dec; 110(52):21030-5. PubMed ID: 24324164
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease.
    Conn PM; Janovick JA
    Mol Cell Endocrinol; 2009 Feb; 299(2):137-45. PubMed ID: 19059461
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists.
    Finch AR; Caunt CJ; Armstrong SP; McArdle CA
    Mol Endocrinol; 2010 Feb; 24(2):423-35. PubMed ID: 20009083
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target.
    Janovick JA; Maya-Nunez G; Conn PM
    J Clin Endocrinol Metab; 2002 Jul; 87(7):3255-62. PubMed ID: 12107234
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.