328 related articles for article (PubMed ID: 22618020)
1. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.
Jiang JX; Chen X; Serizawa N; Szyndralewiez C; Page P; Schröder K; Brandes RP; Devaraj S; Török NJ
Free Radic Biol Med; 2012 Jul; 53(2):289-96. PubMed ID: 22618020
[TBL] [Abstract][Full Text] [Related]
2. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.
Aoyama T; Paik YH; Watanabe S; Laleu B; Gaggini F; Fioraso-Cartier L; Molango S; Heitz F; Merlot C; Szyndralewiez C; Page P; Brenner DA
Hepatology; 2012 Dec; 56(6):2316-27. PubMed ID: 22806357
[TBL] [Abstract][Full Text] [Related]
3. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.
Lan T; Kisseleva T; Brenner DA
PLoS One; 2015; 10(7):e0129743. PubMed ID: 26222337
[TBL] [Abstract][Full Text] [Related]
4. NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.
Sancho P; Mainez J; Crosas-Molist E; Roncero C; Fernández-Rodriguez CM; Pinedo F; Huber H; Eferl R; Mikulits W; Fabregat I
PLoS One; 2012; 7(9):e45285. PubMed ID: 23049784
[TBL] [Abstract][Full Text] [Related]
5. Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.
Gray SP; Jha JC; Kennedy K; van Bommel E; Chew P; Szyndralewiez C; Touyz RM; Schmidt HHHW; Cooper ME; Jandeleit-Dahm KAM
Diabetologia; 2017 May; 60(5):927-937. PubMed ID: 28160092
[TBL] [Abstract][Full Text] [Related]
6. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.
Gorin Y; Cavaglieri RC; Khazim K; Lee DY; Bruno F; Thakur S; Fanti P; Szyndralewiez C; Barnes JL; Block K; Abboud HE
Am J Physiol Renal Physiol; 2015 Jun; 308(11):F1276-87. PubMed ID: 25656366
[TBL] [Abstract][Full Text] [Related]
7. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.
Bettaieb A; Jiang JX; Sasaki Y; Chao TI; Kiss Z; Chen X; Tian J; Katsuyama M; Yabe-Nishimura C; Xi Y; Szyndralewiez C; Schröder K; Shah A; Brandes RP; Haj FG; Török NJ
Gastroenterology; 2015 Aug; 149(2):468-80.e10. PubMed ID: 25888330
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.
Sun Q; Zhang W; Zhong W; Sun X; Zhou Z
Biochim Biophys Acta Gen Subj; 2017 Jan; 1861(1 Pt A):2912-2921. PubMed ID: 27634671
[TBL] [Abstract][Full Text] [Related]
9. Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.
Jha JC; Gray SP; Barit D; Okabe J; El-Osta A; Namikoshi T; Thallas-Bonke V; Wingler K; Szyndralewiez C; Heitz F; Touyz RM; Cooper ME; Schmidt HH; Jandeleit-Dahm KA
J Am Soc Nephrol; 2014 Jun; 25(6):1237-54. PubMed ID: 24511132
[TBL] [Abstract][Full Text] [Related]
10. Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.
García-Ruiz I; Blanes Ruiz N; Rada P; Pardo V; Ruiz L; Blas-García A; Valdecantos MP; Grau Sanz M; Solís Herruzo JA; Valverde ÁM
Redox Biol; 2019 Sep; 26():101263. PubMed ID: 31299613
[TBL] [Abstract][Full Text] [Related]
11. [Effects of M2-type macrophages and GKT137831 on oxidative stress in hepatic stellate cells].
Sun RG; Li J; Shen FJ
Zhonghua Gan Zang Bing Za Zhi; 2024 Mar; 32(3):201-207. PubMed ID: 38584100
[No Abstract] [Full Text] [Related]
12. Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.
Deliyanti D; Wilkinson-Berka JL
J Neuroinflammation; 2015 Jul; 12():136. PubMed ID: 26219952
[TBL] [Abstract][Full Text] [Related]
13. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.
Cha JJ; Min HS; Kim KT; Kim JE; Ghee JY; Kim HW; Lee JE; Han JY; Lee G; Ha HJ; Bae YS; Lee SR; Moon SH; Lee SC; Kim G; Kang YS; Cha DR
Lab Invest; 2017 Apr; 97(4):419-431. PubMed ID: 28165467
[TBL] [Abstract][Full Text] [Related]
14. Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling.
Shin SK; Kim KO; Kim SH; Kwon OS; Choi CS; Jeong SH; Kim YS; Kim JH; Chung MH
J Gastroenterol Hepatol; 2020 Jun; 35(6):1078-1087. PubMed ID: 31907970
[TBL] [Abstract][Full Text] [Related]
15. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation.
Green DE; Murphy TC; Kang BY; Kleinhenz JM; Szyndralewiez C; Page P; Sutliff RL; Hart CM
Am J Respir Cell Mol Biol; 2012 Nov; 47(5):718-26. PubMed ID: 22904198
[TBL] [Abstract][Full Text] [Related]
16. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice.
Paik YH; Iwaisako K; Seki E; Inokuchi S; Schnabl B; Osterreicher CH; Kisseleva T; Brenner DA
Hepatology; 2011 May; 53(5):1730-41. PubMed ID: 21384410
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated protumorigenic interactions.
Sampson N; Brunner E; Weber A; Puhr M; Schäfer G; Szyndralewiez C; Klocker H
Int J Cancer; 2018 Jul; 143(2):383-395. PubMed ID: 29441570
[TBL] [Abstract][Full Text] [Related]
18. Role of NADPH oxidases in the redox biology of liver fibrosis.
Crosas-Molist E; Fabregat I
Redox Biol; 2015 Dec; 6():106-111. PubMed ID: 26204504
[TBL] [Abstract][Full Text] [Related]
19. Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: role of NADPH oxidase.
Wang M; Abais JM; Meng N; Zhang Y; Ritter JK; Li PL; Tang WX
Free Radic Biol Med; 2014 Jun; 71():109-120. PubMed ID: 24657416
[TBL] [Abstract][Full Text] [Related]
20. The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.
Somanna NK; Valente AJ; Krenz M; Fay WP; Delafontaine P; Chandrasekar B
J Cell Physiol; 2016 May; 231(5):1130-41. PubMed ID: 26445208
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]