257 related articles for article (PubMed ID: 22621375)
1. Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.
Bedingfield PT; Cowen D; Acklam P; Cunningham F; Parsons MR; McConkey GA; Fishwick CW; Johnson AP
J Med Chem; 2012 Jun; 55(12):5841-50. PubMed ID: 22621375
[TBL] [Abstract][Full Text] [Related]
2. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Hurt DE; Widom J; Clardy J
Acta Crystallogr D Biol Crystallogr; 2006 Mar; 62(Pt 3):312-23. PubMed ID: 16510978
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase.
Boa AN; Canavan SP; Hirst PR; Ramsey C; Stead AM; McConkey GA
Bioorg Med Chem; 2005 Mar; 13(6):1945-67. PubMed ID: 15727850
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.
Heikkilä T; Ramsey C; Davies M; Galtier C; Stead AM; Johnson AP; Fishwick CW; Boa AN; McConkey GA
J Med Chem; 2007 Jan; 50(2):186-91. PubMed ID: 17228860
[TBL] [Abstract][Full Text] [Related]
5. The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Heikkilä T; Thirumalairajan S; Davies M; Parsons MR; McConkey AG; Fishwick CW; Johnson AP
Bioorg Med Chem Lett; 2006 Jan; 16(1):88-92. PubMed ID: 16236496
[TBL] [Abstract][Full Text] [Related]
6. Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors.
Azeredo LFSP; Coutinho JP; Jabor VAP; Feliciano PR; Nonato MC; Kaiser CR; Menezes CMS; Hammes ASO; Caffarena ER; Hoelz LVB; de Souza NB; Pereira GAN; Cerávolo IP; Krettli AU; Boechat N
Eur J Med Chem; 2017 Jan; 126():72-83. PubMed ID: 27744189
[TBL] [Abstract][Full Text] [Related]
7. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.
Davies M; Heikkilä T; McConkey GA; Fishwick CW; Parsons MR; Johnson AP
J Med Chem; 2009 May; 52(9):2683-93. PubMed ID: 19351152
[TBL] [Abstract][Full Text] [Related]
8. Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria.
Hoelz LV; Calil FA; Nonato MC; Pinheiro LC; Boechat N
Future Med Chem; 2018 Aug; 10(15):1853-1874. PubMed ID: 30019917
[TBL] [Abstract][Full Text] [Related]
9. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Hurt DE; Sutton AE; Clardy J
Bioorg Med Chem Lett; 2006 Mar; 16(6):1610-5. PubMed ID: 16406782
[TBL] [Abstract][Full Text] [Related]
10. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
Walse B; Dufe VT; Svensson B; Fritzson I; Dahlberg L; Khairoullina A; Wellmar U; Al-Karadaghi S
Biochemistry; 2008 Aug; 47(34):8929-36. PubMed ID: 18672895
[TBL] [Abstract][Full Text] [Related]
11. Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors.
Vyas VK; Ghate M
Mini Rev Med Chem; 2011 Oct; 11(12):1039-55. PubMed ID: 21861807
[TBL] [Abstract][Full Text] [Related]
12. Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.
Pavadai E; El Mazouni F; Wittlin S; de Kock C; Phillips MA; Chibale K
J Chem Inf Model; 2016 Mar; 56(3):548-62. PubMed ID: 26915022
[TBL] [Abstract][Full Text] [Related]
13. Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.
Pippione AC; Sainas S; Goyal P; Fritzson I; Cassiano GC; Giraudo A; Giorgis M; Tavella TA; Bagnati R; Rolando B; Caing-Carlsson R; Costa FTM; Andrade CH; Al-Karadaghi S; Boschi D; Friemann R; Lolli ML
Eur J Med Chem; 2019 Feb; 163():266-280. PubMed ID: 30529545
[TBL] [Abstract][Full Text] [Related]
14. In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.
Ross LS; Gamo FJ; Lafuente-Monasterio MJ; Singh OM; Rowland P; Wiegand RC; Wirth DF
J Biol Chem; 2014 Jun; 289(26):17980-95. PubMed ID: 24782313
[TBL] [Abstract][Full Text] [Related]
15. Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.
Malmquist NA; Gujjar R; Rathod PK; Phillips MA
Biochemistry; 2008 Feb; 47(8):2466-75. PubMed ID: 18225919
[TBL] [Abstract][Full Text] [Related]
16. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
Deng X; Gujjar R; El Mazouni F; Kaminsky W; Malmquist NA; Goldsmith EJ; Rathod PK; Phillips MA
J Biol Chem; 2009 Sep; 284(39):26999-7009. PubMed ID: 19640844
[TBL] [Abstract][Full Text] [Related]
17. Synthesis, Design, and Structure⁻Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of
Xu L; Li W; Diao Y; Sun H; Li H; Zhu L; Zhou H; Zhao Z
Molecules; 2018 May; 23(6):. PubMed ID: 29794978
[TBL] [Abstract][Full Text] [Related]
18. Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.
McConkey GA; Bedingfield PTP; Burrell DR; Chambers NC; Cunningham F; Prior TJ; Fishwick CWG; Boa AN
Bioorg Med Chem Lett; 2017 Aug; 27(16):3878-3882. PubMed ID: 28669445
[TBL] [Abstract][Full Text] [Related]
19. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans.
Zameitat E; Gojković Z; Knecht W; Piskur J; Löffler M
FEBS J; 2006 Jul; 273(14):3183-91. PubMed ID: 16774642
[TBL] [Abstract][Full Text] [Related]
20. Dual binding mode of a novel series of DHODH inhibitors.
Baumgartner R; Walloschek M; Kralik M; Gotschlich A; Tasler S; Mies J; Leban J
J Med Chem; 2006 Feb; 49(4):1239-47. PubMed ID: 16480261
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
