BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

267 related articles for article (PubMed ID: 22642269)

  • 1. Development of a Grp94 inhibitor.
    Duerfeldt AS; Peterson LB; Maynard JC; Ng CL; Eletto D; Ostrovsky O; Shinogle HE; Moore DS; Argon Y; Nicchitta CV; Blagg BS
    J Am Chem Soc; 2012 Jun; 134(23):9796-804. PubMed ID: 22642269
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
    Que NLS; Crowley VM; Duerfeldt AS; Zhao J; Kent CN; Blagg BSJ; Gewirth DT
    J Med Chem; 2018 Apr; 61(7):2793-2805. PubMed ID: 29528635
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
    Jiang F; Guo AP; Xu JC; You QD; Xu XL
    J Med Chem; 2018 Nov; 61(21):9513-9533. PubMed ID: 30351001
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
    Immormino RM; Metzger LE; Reardon PN; Dollins DE; Blagg BS; Gewirth DT
    J Mol Biol; 2009 May; 388(5):1033-42. PubMed ID: 19361515
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide.
    Krukenberg KA; Böttcher UM; Southworth DR; Agard DA
    Protein Sci; 2009 Sep; 18(9):1815-27. PubMed ID: 19554567
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.
    Mishra SJ; Ghosh S; Stothert AR; Dickey CA; Blagg BS
    ACS Chem Biol; 2017 Jan; 12(1):244-253. PubMed ID: 27959508
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
    Lee JH; Kang KW; Kim JE; Hwang SW; Park JH; Kim SH; Ji JH; Kim TG; Nam HY; Roh MS; Lee EH; Park MI; Kim MS; Lee HW
    Int J Clin Exp Pathol; 2015; 8(8):9487-93. PubMed ID: 26464709
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Grp on the Hsp90 mechanism.
    Richter K; Reinstein J; Buchner J
    Mol Cell; 2007 Oct; 28(2):177-9. PubMed ID: 17964255
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Exploring the Functional Complementation between Grp94 and Hsp90.
    Maharaj KA; Que NL; Hong F; Huck JD; Gill SK; Wu S; Li Z; Gewirth DT
    PLoS One; 2016; 11(11):e0166271. PubMed ID: 27824935
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The ER Chaperones BiP and Grp94 Regulate the Formation of Insulin-Like Growth Factor 2 (IGF2) Oligomers.
    Jin Y; Kotler JLM; Wang S; Huang B; Halpin JC; Street TO
    J Mol Biol; 2021 Jun; 433(13):166963. PubMed ID: 33811917
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of radamide analogs as Grp94 inhibitors.
    Muth A; Crowley V; Khandelwal A; Mishra S; Zhao J; Hall J; Blagg BS
    Bioorg Med Chem; 2014 Aug; 22(15):4083-98. PubMed ID: 25027801
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones.
    Dollins DE; Warren JJ; Immormino RM; Gewirth DT
    Mol Cell; 2007 Oct; 28(1):41-56. PubMed ID: 17936703
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The ATPase cycle of the endoplasmic chaperone Grp94.
    Frey S; Leskovar A; Reinstein J; Buchner J
    J Biol Chem; 2007 Dec; 282(49):35612-20. PubMed ID: 17925398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity.
    Wassenberg JJ; Reed RC; Nicchitta CV
    J Biol Chem; 2000 Jul; 275(30):22806-14. PubMed ID: 10816560
    [TBL] [Abstract][Full Text] [Related]  

  • 15. GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum.
    Marzec M; Eletto D; Argon Y
    Biochim Biophys Acta; 2012 Mar; 1823(3):774-87. PubMed ID: 22079671
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy.
    Jahn M; Tych K; Girstmair H; Steinmaßl M; Hugel T; Buchner J; Rief M
    Structure; 2018 Jan; 26(1):96-105.e4. PubMed ID: 29276035
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.
    Ghosh S; Shinogle HE; Galeva NA; Dobrowsky RT; Blagg BS
    J Biol Chem; 2016 Apr; 291(16):8309-23. PubMed ID: 26872972
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Adenosine nucleotides and the regulation of GRP94-client protein interactions.
    Rosser MF; Trotta BM; Marshall MR; Berwin B; Nicchitta CV
    Biochemistry; 2004 Jul; 43(27):8835-45. PubMed ID: 15236592
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
    Chu F; Maynard JC; Chiosis G; Nicchitta CV; Burlingame AL
    Protein Sci; 2006 Jun; 15(6):1260-9. PubMed ID: 16731965
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages.
    Wassenberg JJ; Dezfulian C; Nicchitta CV
    J Cell Sci; 1999 Jul; 112 ( Pt 13)():2167-75. PubMed ID: 10362546
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.