These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

124 related articles for article (PubMed ID: 22646918)

  • 1. Theoretical study on HF elimination and aromatization mechanisms: a case of pyridoxal 5' phosphate-dependent enzyme.
    Gökcan H; Konuklar FA
    J Org Chem; 2012 Jul; 77(13):5533-43. PubMed ID: 22646918
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stereoelectronic explanations for the mechanistic details of transimination and HF elimination reactions.
    Gökcan H; Konuklar FA
    J Mol Graph Model; 2014 Jun; 51():173-83. PubMed ID: 24929816
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Theoretical studies on the inactivation mechanism of γ-aminobutyric acid aminotransferase.
    Durak AT; Gökcan H; Konuklar FA
    Org Biomol Chem; 2011 Jul; 9(14):5162-71. PubMed ID: 21647516
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.
    Storici P; De Biase D; Bossa F; Bruno S; Mozzarelli A; Peneff C; Silverman RB; Schirmer T
    J Biol Chem; 2004 Jan; 279(1):363-73. PubMed ID: 14534310
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Active site model for gamma-aminobutyrate aminotransferase explains substrate specificity and inhibitor reactivities.
    Toney MD; Pascarella S; De Biase D
    Protein Sci; 1995 Nov; 4(11):2366-74. PubMed ID: 8563634
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular dynamics simulations of apo, holo, and inactivator bound GABA-at reveal the role of active site residues in PLP dependent enzymes.
    Gökcan H; Monard G; Sungur Konuklar FA
    Proteins; 2016 Jul; 84(7):875-91. PubMed ID: 26800298
    [TBL] [Abstract][Full Text] [Related]  

  • 7. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.
    Wang Z; Yuan H; Nikolic D; Van Breemen RB; Silverman RB
    Biochemistry; 2006 Dec; 45(48):14513-22. PubMed ID: 17128990
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
    Belitsky BR
    J Mol Biol; 2004 Jul; 340(4):655-64. PubMed ID: 15223311
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.
    Lightcap ES; Hopkins MH; Olson GT; Silverman RB
    Bioorg Med Chem; 1995 May; 3(5):579-85. PubMed ID: 7648206
    [TBL] [Abstract][Full Text] [Related]  

  • 10. DFT studies on Schiff base formation of vitamin B6 analogues. Reaction between a pyridoxamine-analogue and carbonyl compounds.
    Ortega-Castro J; Adrover M; Frau J; Salvà A; Donoso J; Muñoz F
    J Phys Chem A; 2010 Apr; 114(13):4634-40. PubMed ID: 20235562
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
    Mascarenhas R; Le HV; Clevenger KD; Lehrer HJ; Ringe D; Kelleher NL; Silverman RB; Liu D
    Biochemistry; 2017 Sep; 56(37):4951-4961. PubMed ID: 28816437
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structures of a γ-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct.
    Bruce H; Nguyen Tuan A; Mangas Sánchez J; Leese C; Hopwood J; Hyde R; Hart S; Turkenburg JP; Grogan G
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2012 Oct; 68(Pt 10):1175-80. PubMed ID: 23027742
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding.
    Clift MD; Ji H; Deniau GP; O'Hagan D; Silverman RB
    Biochemistry; 2007 Dec; 46(48):13819-28. PubMed ID: 17988152
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chemical inactivation of bacterial GABA aminotransferase.
    Tunnicliff G; Crites GJ
    Biochem Mol Biol Int; 1998 Sep; 46(1):43-54. PubMed ID: 9784838
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structure of γ-aminobutyrate aminotransferase in complex with a PLP-GABA adduct from Corynebacterium glutamicum.
    Hong J; Kim KJ
    Biochem Biophys Res Commun; 2019 Jun; 514(3):601-606. PubMed ID: 31072617
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pyritinol and the enzymes of gamma-aminobutyric acid (GABA) synthesis and degradation.
    Turský T
    Physiol Bohemoslov; 1988; 37(2):135-43. PubMed ID: 2975003
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).
    Lee H; Doud EH; Wu R; Sanishvili R; Juncosa JI; Liu D; Kelleher NL; Silverman RB
    J Am Chem Soc; 2015 Feb; 137(7):2628-40. PubMed ID: 25616005
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Formation of Schiff bases of O-phosphorylethanolamine and O-phospho-D,L-serine with pyridoxal 5'-phosphate. experimental and theoretical studies.
    Vilanova B; Gallardo JM; Caldés C; Adrover M; Ortega-Castro J; Muñoz F; Donoso J
    J Phys Chem A; 2012 Mar; 116(8):1897-905. PubMed ID: 22280506
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy.
    Storici P; Capitani G; De Biase D; Moser M; John RA; Jansonius JN; Schirmer T
    Biochemistry; 1999 Jul; 38(27):8628-34. PubMed ID: 10393538
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A quantum mechanical/molecular mechanical study on the catalysis of the pyridoxal 5'-phosphate-dependent enzyme L-serine dehydratase.
    Zhao Z; Liu H
    J Phys Chem B; 2008 Oct; 112(41):13091-100. PubMed ID: 18811194
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.