These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
5. Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Volta M; Cataldi S; Beccano-Kelly D; Munsie L; Tatarnikov I; Chou P; Bergeron S; Mitchell E; Lim R; Khinda J; Lloret A; Bennett CF; Paradiso C; Morari M; Farrer MJ; Milnerwood AJ Parkinsonism Relat Disord; 2015 Oct; 21(10):1156-63. PubMed ID: 26282470 [TBL] [Abstract][Full Text] [Related]
6. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake. Zhou H; Huang C; Tong J; Hong WC; Liu YJ; Xia XG Int J Biol Sci; 2011; 7(6):753-61. PubMed ID: 21698001 [TBL] [Abstract][Full Text] [Related]
7. Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation. Matikainen-Ankney BA; Kezunovic N; Mesias RE; Tian Y; Williams FM; Huntley GW; Benson DL J Neurosci; 2016 Jul; 36(27):7128-41. PubMed ID: 27383589 [TBL] [Abstract][Full Text] [Related]
8. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. Li X; Patel JC; Wang J; Avshalumov MV; Nicholson C; Buxbaum JD; Elder GA; Rice ME; Yue Z J Neurosci; 2010 Feb; 30(5):1788-97. PubMed ID: 20130188 [TBL] [Abstract][Full Text] [Related]
9. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. Walker MD; Volta M; Cataldi S; Dinelle K; Beccano-Kelly D; Munsie L; Kornelsen R; Mah C; Chou P; Co K; Khinda J; Mroczek M; Bergeron S; Yu K; Cao LP; Funk N; Ott T; Galter D; Riess O; Biskup S; Milnerwood AJ; Stoessl AJ; Farrer MJ; Sossi V J Parkinsons Dis; 2014; 4(3):483-98. PubMed ID: 25000966 [TBL] [Abstract][Full Text] [Related]
10. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Tong Y; Yamaguchi H; Giaime E; Boyle S; Kopan R; Kelleher RJ; Shen J Proc Natl Acad Sci U S A; 2010 May; 107(21):9879-84. PubMed ID: 20457918 [TBL] [Abstract][Full Text] [Related]
11. Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice. Huang G; Bloodgood DW; Kang J; Shahapal A; Chen P; Kaganovsky K; Kim JI; Ding JB; Shen J J Neurosci; 2022 Jun; 42(23):4755-4765. PubMed ID: 35534227 [TBL] [Abstract][Full Text] [Related]
12. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Ramonet D; Daher JP; Lin BM; Stafa K; Kim J; Banerjee R; Westerlund M; Pletnikova O; Glauser L; Yang L; Liu Y; Swing DA; Beal MF; Troncoso JC; McCaffery JM; Jenkins NA; Copeland NG; Galter D; Thomas B; Lee MK; Dawson TM; Dawson VL; Moore DJ PLoS One; 2011 Apr; 6(4):e18568. PubMed ID: 21494637 [TBL] [Abstract][Full Text] [Related]
13. Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Sloan M; Alegre-Abarrategui J; Wade-Martins R Biochem Soc Trans; 2012 Oct; 40(5):1080-5. PubMed ID: 22988869 [TBL] [Abstract][Full Text] [Related]
14. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Beccano-Kelly DA; Volta M; Munsie LN; Paschall SA; Tatarnikov I; Co K; Chou P; Cao LP; Bergeron S; Mitchell E; Han H; Melrose HL; Tapia L; Raymond LA; Farrer MJ; Milnerwood AJ Hum Mol Genet; 2015 Mar; 24(5):1336-49. PubMed ID: 25343991 [TBL] [Abstract][Full Text] [Related]
18. (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse. Chou JS; Chen CY; Chen YL; Weng YH; Yeh TH; Lu CS; Chang YM; Wang HL Neurobiol Dis; 2014 Aug; 68():190-9. PubMed ID: 24830390 [TBL] [Abstract][Full Text] [Related]
19. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. Plowey ED; Cherra SJ; Liu YJ; Chu CT J Neurochem; 2008 May; 105(3):1048-56. PubMed ID: 18182054 [TBL] [Abstract][Full Text] [Related]
20. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Ho PW; Leung CT; Liu H; Pang SY; Lam CS; Xian J; Li L; Kung MH; Ramsden DB; Ho SL Autophagy; 2020 Feb; 16(2):347-370. PubMed ID: 30983487 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]