These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

87 related articles for article (PubMed ID: 22650795)

  • 1. Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems.
    Vauquelin G; Van Liefde I
    Expert Opin Drug Discov; 2012 Jul; 7(7):583-95. PubMed ID: 22650795
    [TBL] [Abstract][Full Text] [Related]  

  • 2. On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.
    Vauquelin G
    Expert Opin Drug Discov; 2015 Oct; 10(10):1085-98. PubMed ID: 26165720
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhancer and competitive allosteric modulation model for G-protein-coupled receptors.
    Pietra D; Borghini A; Breschi MC; Bianucci AM
    J Theor Biol; 2010 Dec; 267(4):663-75. PubMed ID: 20800599
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies.
    Barrondo S; Sallés J
    Neuropharmacology; 2009 Feb; 56(2):455-62. PubMed ID: 18951909
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery and characterization of orthosteric and allosteric muscarinic M2 acetylcholine receptor ligands by affinity selection-mass spectrometry.
    Whitehurst CE; Nazef N; Annis DA; Hou Y; Murphy DM; Spacciapoli P; Yao Z; Ziebell MR; Cheng CC; Shipps GW; Felsch JS; Lau D; Nash HM
    J Biomol Screen; 2006 Mar; 11(2):194-207. PubMed ID: 16490772
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.
    Ehlert FJ
    Mol Pharmacol; 1988 Feb; 33(2):187-94. PubMed ID: 2828914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Determining allosteric modulator mechanism of action: integration of radioligand binding and functional assay data.
    Langmead CJ
    Methods Mol Biol; 2011; 746():195-209. PubMed ID: 21607858
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time.
    Vauquelin G
    Expert Opin Drug Discov; 2010 Oct; 5(10):927-41. PubMed ID: 22823988
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.
    Packeu A; Wennerberg M; Balendran A; Vauquelin G
    Br J Pharmacol; 2010 Nov; 161(6):1311-28. PubMed ID: 20946109
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.
    Avlani VA; McLoughlin DJ; Sexton PM; Christopoulos A
    J Pharmacol Exp Ther; 2008 Jun; 325(3):927-34. PubMed ID: 18322151
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Avidity and positive allosteric modulation/cooperativity act hand in hand to increase the residence time of bivalent receptor ligands.
    Vauquelin G; Bricca G; Van Liefde I
    Fundam Clin Pharmacol; 2014 Oct; 28(5):530-43. PubMed ID: 24118041
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand dissociation constants from competition binding assays: errors associated with ligand depletion.
    Goldstein A; Barrett RW
    Mol Pharmacol; 1987 Jun; 31(6):603-9. PubMed ID: 3600604
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Measuring receptor target coverage: a radioligand competition binding protocol for assessing the association and dissociation rates of unlabeled compounds.
    Sykes DA; Dowling MR; Charlton SJ
    Curr Protoc Pharmacol; 2010 Sep; Chapter 9():Unit 9.14. PubMed ID: 22294377
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
    Malany S; Hernandez LM; Smith WF; Crowe PD; Hoare SR
    J Recept Signal Transduct Res; 2009; 29(2):84-93. PubMed ID: 19308787
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.
    Baraldi PG; Romagnoli R; Pavani MG; Nuñez Mdel C; Tabrizi MA; Shryock JC; Leung E; Moorman AR; Uluoglu C; Iannotta V; Merighi S; Borea PA
    J Med Chem; 2003 Feb; 46(5):794-809. PubMed ID: 12593659
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
    Tränkle C; Weyand O; Voigtländer U; Mynett A; Lazareno S; Birdsall NJ; Mohr K
    Mol Pharmacol; 2003 Jul; 64(1):180-90. PubMed ID: 12815174
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action.
    Vauquelin G; Charlton SJ
    Br J Pharmacol; 2010 Oct; 161(3):488-508. PubMed ID: 20880390
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter.
    Nandi A; Dersch CM; Kulshrestha M; Ananthan S; Rothman RB
    Synapse; 2004 Sep; 53(3):176-83. PubMed ID: 15236350
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The pharmacological basis of receptor binding.
    Schütz W
    Wien Klin Wochenschr; 1991; 103(15):438-42. PubMed ID: 1656614
    [TBL] [Abstract][Full Text] [Related]  

  • 20. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
    Urwyler S; Pozza MF; Lingenhoehl K; Mosbacher J; Lampert C; Froestl W; Koller M; Kaupmann K
    J Pharmacol Exp Ther; 2003 Oct; 307(1):322-30. PubMed ID: 12954816
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.