BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 22651555)

  • 1. Biomarkers and biomeasures: key enablers for pharmacokinetic-pharmacodynamic modeling in drug discovery and development.
    Agoram BM; van der Graaf PH
    Bioanalysis; 2012 Jun; 4(10):1143-5. PubMed ID: 22651555
    [No Abstract]   [Full Text] [Related]  

  • 2. The role of pharmacokinetic and pharmacokinetic/pharmacodynamic modeling in drug discovery and development.
    Yu XQ; Wilson AG
    Future Med Chem; 2010 Jun; 2(6):923-8. PubMed ID: 21426110
    [No Abstract]   [Full Text] [Related]  

  • 3. Physiologically based pharmacokinetic (PBPK) modeling and simulation: applications in lead optimization.
    Peters SA; Ungell AL; Dolgos H
    Curr Opin Drug Discov Devel; 2009 Jul; 12(4):509-18. PubMed ID: 19562647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chutes and ladders on the critical path:comparative effectiveness, product value, and the use of biomarkers in drug development.
    Woodcock J
    Clin Pharmacol Ther; 2009 Jul; 86(1):12-4. PubMed ID: 19536116
    [No Abstract]   [Full Text] [Related]  

  • 5. Biomarkers in clinical drug development.
    Gobburu JV
    Clin Pharmacol Ther; 2009 Jul; 86(1):26-7. PubMed ID: 19536121
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An industrial perspective on contemporary applications of PBPK models in drug discovery and development.
    Smith BJ
    Biopharm Drug Dispos; 2012 Mar; 33(2):53-4. PubMed ID: 22407480
    [No Abstract]   [Full Text] [Related]  

  • 7. Predicting Human Pharmacokinetics: Physiologically Based Pharmacokinetic Modeling and In Silico ADME Prediction in Early Drug Discovery.
    Shi J; Zha W
    Eur J Drug Metab Pharmacokinet; 2019 Feb; 44(1):135-137. PubMed ID: 30136219
    [No Abstract]   [Full Text] [Related]  

  • 8. Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development.
    Oosterhuis B
    Bioanalysis; 2010 Mar; 2(3):377-9. PubMed ID: 21083246
    [No Abstract]   [Full Text] [Related]  

  • 9. Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development.
    Van Der Graaf PH; Gabrielsson J
    Future Med Chem; 2009 Nov; 1(8):1371-4. PubMed ID: 21426051
    [No Abstract]   [Full Text] [Related]  

  • 10. Flow cytometry-based biomarkers in translational medicine and drug development.
    Litwin V; O'Gorman MR
    J Immunol Methods; 2011 Jan; 363(2):101-2. PubMed ID: 20888828
    [No Abstract]   [Full Text] [Related]  

  • 11. Application of PBPK modelling in drug discovery and development at Pfizer.
    Jones HM; Dickins M; Youdim K; Gosset JR; Attkins NJ; Hay TL; Gurrell IK; Logan YR; Bungay PJ; Jones BC; Gardner IB
    Xenobiotica; 2012 Jan; 42(1):94-106. PubMed ID: 22035569
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development.
    Agoram BM; Demin O
    Drug Discov Today; 2011 Dec; 16(23-24):1031-6. PubMed ID: 22020181
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!
    Rostami-Hodjegan A; Tamai I; Pang KS
    Biopharm Drug Dispos; 2012 Mar; 33(2):47-50. PubMed ID: 22351594
    [No Abstract]   [Full Text] [Related]  

  • 14. Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.
    Jones HM; Chen Y; Gibson C; Heimbach T; Parrott N; Peters SA; Snoeys J; Upreti VV; Zheng M; Hall SD
    Clin Pharmacol Ther; 2015 Mar; 97(3):247-62. PubMed ID: 25670209
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Beyond biomarkers: an opportunity to address the 'pharmacodynamic gap' in pediatric drug development.
    Kearns GL
    Biomark Med; 2010 Dec; 4(6):783-6. PubMed ID: 21133695
    [No Abstract]   [Full Text] [Related]  

  • 16. Multiscale modeling in drug discovery and development: future opportunities and present challenges.
    Vicini P
    Clin Pharmacol Ther; 2010 Jul; 88(1):126-9. PubMed ID: 20520608
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Best practice in the use of physiologically based pharmacokinetic modeling and simulation to address clinical pharmacology regulatory questions.
    Zhao P; Rowland M; Huang SM
    Clin Pharmacol Ther; 2012 Jul; 92(1):17-20. PubMed ID: 22713733
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Impact of modeling and simulation: myth or fact?
    Allerheiligen SR
    Clin Pharmacol Ther; 2014 Oct; 96(4):413-5. PubMed ID: 25236663
    [No Abstract]   [Full Text] [Related]  

  • 19. The promise of imaging biomarkers.
    Drug News Perspect; 2010 Mar; 23(2):119-23. PubMed ID: 20369077
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Optimizing the use of biomarkers, surrogate endpoints, and clinical endpoints for more efficient drug development.
    Colburn WA
    J Clin Pharmacol; 2000 Dec; 40(12 Pt 2):1419-27. PubMed ID: 11185662
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.