BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

253 related articles for article (PubMed ID: 22661948)

  • 21. Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes.
    Madlensky L; Natarajan L; Tchu S; Pu M; Mortimer J; Flatt SW; Nikoloff DM; Hillman G; Fontecha MR; Lawrence HJ; Parker BA; Wu AH; Pierce JP
    Clin Pharmacol Ther; 2011 May; 89(5):718-25. PubMed ID: 21430657
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The use of the 13C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels.
    Opdam FL; Dezentje VO; den Hartigh J; Modak AS; Vree R; Batman E; Smorenburg CH; Nortier JW; Gelderblom H; Guchelaar HJ
    Cancer Chemother Pharmacol; 2013 Mar; 71(3):593-601. PubMed ID: 23228987
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
    Khor CC; Winter S; Sutiman N; Mürdter TE; Chen S; Lim JSL; Li Z; Li J; Sim KS; Ganchev B; Eccles D; Eccles B; Tapper W; Zgheib NK; Tfayli A; Ng RCH; Yap YS; Lim E; Wong M; Wong NS; Ang PCS; Dent R; Tremmel R; Klein K; Schaeffeler E; Zhou Y; Lauschke VM; Eichelbaum M; Schwab M; Brauch HB; Chowbay B; Schroth W
    Clin Pharmacol Ther; 2023 Mar; 113(3):712-723. PubMed ID: 36629403
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Clinical
    Mulder TAM; de With M; Del Re M; Danesi R; Mathijssen RHJ; van Schaik RHN
    Cancers (Basel); 2021 Feb; 13(4):. PubMed ID: 33673305
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
    Lim YC; Li L; Desta Z; Zhao Q; Rae JM; Flockhart DA; Skaar TC
    J Pharmacol Exp Ther; 2006 Aug; 318(2):503-12. PubMed ID: 16690721
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Comparative metabolic study between two selective estrogen receptor modulators, toremifene and tamoxifen, in human liver microsomes.
    Watanabe M; Watanabe N; Maruyama S; Kawashiro T
    Drug Metab Pharmacokinet; 2015 Oct; 30(5):325-33. PubMed ID: 26423799
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol.
    Chao TC; Pan WC; Tsai YF; Chou YC; Liu YR; Wang SF; Chen YJ; Souček P; Ueng YF
    Toxicol Appl Pharmacol; 2019 Sep; 378():114619. PubMed ID: 31195002
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity.
    Welzen ME; Dezentjé VO; van Schaik RH; Colbers AP; Guchelaar HJ; van Erp NP; den Hartigh J; Burger DM; van Laarhoven HW
    Ther Drug Monit; 2015 Aug; 37(4):501-7. PubMed ID: 26192892
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Adjusting the dose of tamoxifen in patients with early breast cancer and CYP2D6 poor metabolizer phenotype.
    Martinez de Dueñas E; Ochoa Aranda E; Blancas Lopez-Barajas I; Ferrer Magdalena T; Bandrés Moya F; Chicharro García LM; Gómez Capilla JA; Zafra Ceres M; de Haro T; Romero Llorens R; Ferrer Albiach C; Ferriols Lisart R; Chover Lara D; López Rodríguez A; Munárriz Ferrandis J; Olmos Antón S
    Breast; 2014 Aug; 23(4):400-6. PubMed ID: 24685597
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
    Goetz MP; Knox SK; Suman VJ; Rae JM; Safgren SL; Ames MM; Visscher DW; Reynolds C; Couch FJ; Lingle WL; Weinshilboum RM; Fritcher EG; Nibbe AM; Desta Z; Nguyen A; Flockhart DA; Perez EA; Ingle JN
    Breast Cancer Res Treat; 2007 Jan; 101(1):113-21. PubMed ID: 17115111
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen.
    Kanji CR; Nyabadza G; Nhachi C; Masimirembwa C
    J Pers Med; 2023 Jan; 13(2):. PubMed ID: 36836506
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Clinical Trial:
    Khalaj Z; Baratieh Z; Nikpour P; Schwab M; Schaeffeler E; Mokarian F; Khanahmad H; Salehi R; Mürdter TE; Salehi M
    Front Pharmacol; 2019; 10():530. PubMed ID: 31178724
    [No Abstract]   [Full Text] [Related]  

  • 33. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.
    Wu X; Hawse JR; Subramaniam M; Goetz MP; Ingle JN; Spelsberg TC
    Cancer Res; 2009 Mar; 69(5):1722-7. PubMed ID: 19244106
    [TBL] [Abstract][Full Text] [Related]  

  • 34. CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy.
    Teft WA; Gong IY; Dingle B; Potvin K; Younus J; Vandenberg TA; Brackstone M; Perera FE; Choi YH; Zou G; Legan RM; Tirona RG; Kim RB
    Breast Cancer Res Treat; 2013 May; 139(1):95-105. PubMed ID: 23580071
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Multigene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19, and ABCB1.
    Powers JL; Buys SS; Fletcher D; Melis R; Johnson-Davis KL; Lyon E; Malmberg EM; McMillin GA
    J Clin Pharmacol; 2016 Dec; 56(12):1570-1581. PubMed ID: 27198207
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen.
    Kim J; Coss CC; Barrett CM; Mohler ML; Bohl CE; Li CM; He Y; Veverka KA; Dalton JT
    Int J Cancer; 2013 Mar; 132(6):1475-85. PubMed ID: 22915089
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.
    Ahmed NS; Elghazawy NH; ElHady AK; Engel M; Hartmann RW; Abadi AH
    Eur J Med Chem; 2016 Apr; 112():171-179. PubMed ID: 26896706
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts.
    Gong IY; Teft WA; Ly J; Chen YH; Alicke B; Kim RB; Choo EF
    Breast Cancer Res Treat; 2013 May; 139(1):61-9. PubMed ID: 23605084
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice.
    Ruddy KJ; Desantis SD; Gelman RS; Wu AH; Punglia RS; Mayer EL; Tolaney SM; Winer EP; Partridge AH; Burstein HJ
    Breast Cancer Res Treat; 2013 Oct; 141(3):421-7. PubMed ID: 24062210
    [TBL] [Abstract][Full Text] [Related]  

  • 40.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.