303 related articles for article (PubMed ID: 22664975)
1. Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.
Christ F; Shaw S; Demeulemeester J; Desimmie BA; Marchand A; Butler S; Smets W; Chaltin P; Westby M; Debyser Z; Pickford C
Antimicrob Agents Chemother; 2012 Aug; 56(8):4365-74. PubMed ID: 22664975
[TBL] [Abstract][Full Text] [Related]
2. Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Le Rouzic E; Bonnard D; Chasset S; Bruneau JM; Chevreuil F; Le Strat F; Nguyen J; Beauvoir R; Amadori C; Brias J; Vomscheid S; Eiler S; Lévy N; Delelis O; Deprez E; Saïb A; Zamborlini A; Emiliani S; Ruff M; Ledoussal B; Moreau F; Benarous R
Retrovirology; 2013 Nov; 10():144. PubMed ID: 24261564
[TBL] [Abstract][Full Text] [Related]
3. Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.
Xue W; Liu H; Yao X
PLoS One; 2014; 9(3):e90799. PubMed ID: 24599328
[TBL] [Abstract][Full Text] [Related]
4. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.
Christ F; Debyser Z
Virology; 2013 Jan; 435(1):102-9. PubMed ID: 23217620
[TBL] [Abstract][Full Text] [Related]
5. Quinoline-based Protein-protein Interaction Inhibitors of LEDGF/p75 and HIV Integrase: An In Silico Study.
Chhokar N; Kalra S; Chauhan M; Munshi A; Kumar R
Curr Top Med Chem; 2018; 18(32):2800-2815. PubMed ID: 30747071
[TBL] [Abstract][Full Text] [Related]
6. New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
Tsiang M; Jones GS; Niedziela-Majka A; Kan E; Lansdon EB; Huang W; Hung M; Samuel D; Novikov N; Xu Y; Mitchell M; Guo H; Babaoglu K; Liu X; Geleziunas R; Sakowicz R
J Biol Chem; 2012 Jun; 287(25):21189-203. PubMed ID: 22535962
[TBL] [Abstract][Full Text] [Related]
7. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L; Dharmarajan V; Serrao E; Hoyte A; Larue RC; Slaughter A; Sharma A; Plumb MR; Kessl JJ; Fuchs JR; Bushman FD; Engelman AN; Griffin PR; Kvaratskhelia M
ACS Chem Biol; 2016 May; 11(5):1313-21. PubMed ID: 26910179
[TBL] [Abstract][Full Text] [Related]
8. LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.
Schrijvers R; De Rijck J; Demeulemeester J; Adachi N; Vets S; Ronen K; Christ F; Bushman FD; Debyser Z; Gijsbers R
PLoS Pathog; 2012; 8(3):e1002558. PubMed ID: 22396646
[TBL] [Abstract][Full Text] [Related]
9. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
Christ F; Voet A; Marchand A; Nicolet S; Desimmie BA; Marchand D; Bardiot D; Van der Veken NJ; Van Remoortel B; Strelkov SV; De Maeyer M; Chaltin P; Debyser Z
Nat Chem Biol; 2010 Jun; 6(6):442-8. PubMed ID: 20473303
[TBL] [Abstract][Full Text] [Related]
10. A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A; Slaughter A; Jena N; Feng L; Kessl JJ; Fadel HJ; Malani N; Male F; Wu L; Poeschla E; Bushman FD; Fuchs JR; Kvaratskhelia M
PLoS Pathog; 2014 May; 10(5):e1004171. PubMed ID: 24874515
[TBL] [Abstract][Full Text] [Related]
11. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L; Sharma A; Slaughter A; Jena N; Koh Y; Shkriabai N; Larue RC; Patel PA; Mitsuya H; Kessl JJ; Engelman A; Fuchs JR; Kvaratskhelia M
J Biol Chem; 2013 May; 288(22):15813-20. PubMed ID: 23615903
[TBL] [Abstract][Full Text] [Related]
12. LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.
Desimmie BA; Schrijvers R; Demeulemeester J; Borrenberghs D; Weydert C; Thys W; Vets S; Van Remoortel B; Hofkens J; De Rijck J; Hendrix J; Bannert N; Gijsbers R; Christ F; Debyser Z
Retrovirology; 2013 May; 10():57. PubMed ID: 23721378
[TBL] [Abstract][Full Text] [Related]
13. LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection.
Debyser Z; Bruggemans A; Van Belle S; Janssens J; Christ F
Adv Exp Med Biol; 2021; 1322():97-114. PubMed ID: 34258738
[TBL] [Abstract][Full Text] [Related]
14. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Bonnard D; Le Rouzic E; Eiler S; Amadori C; Orlov I; Bruneau JM; Brias J; Barbion J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Moreau F; Saïb A; Klaholz BP; Emiliani S; Ruff M; Zamborlini A; Benarous R
J Biol Chem; 2018 Apr; 293(16):6172-6186. PubMed ID: 29507092
[TBL] [Abstract][Full Text] [Related]
15. The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
Amadori C; van der Velden YU; Bonnard D; Orlov I; van Bel N; Le Rouzic E; Miralles L; Brias J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Mayr L; Moreau F; García F; Gatell J; Zamborlini A; Emiliani S; Ruff M; Klaholz BP; Moog C; Berkhout B; Plana M; Benarous R
Retrovirology; 2017 Nov; 14(1):50. PubMed ID: 29121950
[TBL] [Abstract][Full Text] [Related]
16. The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75.
Zhang DW; Yan HL; Xu XS; Xu L; Yin ZH; Chang S; Luo H
J Enzyme Inhib Med Chem; 2020 Dec; 35(1):906-912. PubMed ID: 32228103
[TBL] [Abstract][Full Text] [Related]
17. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer.
Sun J; Patel K; Hume J; Pigza JA; Donahue MG; Kessl JJ
J Biol Chem; 2021; 296():100363. PubMed ID: 33539919
[TBL] [Abstract][Full Text] [Related]
18. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.
Vranckx LS; Demeulemeester J; Saleh S; Boll A; Vansant G; Schrijvers R; Weydert C; Battivelli E; Verdin E; Cereseto A; Christ F; Gijsbers R; Debyser Z
EBioMedicine; 2016 Jun; 8():248-264. PubMed ID: 27428435
[TBL] [Abstract][Full Text] [Related]
19. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction.
Zhang FH; Debnath B; Xu ZL; Yang LM; Song LR; Zheng YT; Neamati N; Long YQ
Eur J Med Chem; 2017 Jan; 125():1051-1063. PubMed ID: 27810592
[TBL] [Abstract][Full Text] [Related]
20. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.
Jurado KA; Engelman A
Expert Rev Mol Med; 2013 Nov; 15():e14. PubMed ID: 24274067
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]