BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

459 related articles for article (PubMed ID: 22684333)

  • 1. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
    Capparelli C; Whitaker-Menezes D; Guido C; Balliet R; Pestell TG; Howell A; Sneddon S; Pestell RG; Martinez-Outschoorn U; Lisanti MP; Sotgia F
    Cell Cycle; 2012 Jun; 11(12):2272-84. PubMed ID: 22684333
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
    Guido C; Whitaker-Menezes D; Capparelli C; Balliet R; Lin Z; Pestell RG; Howell A; Aquila S; Andò S; Martinez-Outschoorn U; Sotgia F; Lisanti MP
    Cell Cycle; 2012 Aug; 11(16):3019-35. PubMed ID: 22874531
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
    Martinez-Outschoorn UE; Trimmer C; Lin Z; Whitaker-Menezes D; Chiavarina B; Zhou J; Wang C; Pavlides S; Martinez-Cantarin MP; Capozza F; Witkiewicz AK; Flomenberg N; Howell A; Pestell RG; Caro J; Lisanti MP; Sotgia F
    Cell Cycle; 2010 Sep; 9(17):3515-33. PubMed ID: 20855962
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
    Avena P; Anselmo W; Whitaker-Menezes D; Wang C; Pestell RG; Lamb RS; Hulit J; Casaburi I; Andò S; Martinez-Outschoorn UE; Lisanti MP; Sotgia F
    Cell Cycle; 2013 May; 12(9):1360-70. PubMed ID: 23574724
    [TBL] [Abstract][Full Text] [Related]  

  • 5. HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
    Chiavarina B; Whitaker-Menezes D; Migneco G; Martinez-Outschoorn UE; Pavlides S; Howell A; Tanowitz HB; Casimiro MC; Wang C; Pestell RG; Grieshaber P; Caro J; Sotgia F; Lisanti MP
    Cell Cycle; 2010 Sep; 9(17):3534-51. PubMed ID: 20864819
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
    Chiavarina B; Whitaker-Menezes D; Martinez-Outschoorn UE; Witkiewicz AK; Birbe R; Howell A; Pestell RG; Smith J; Daniel R; Sotgia F; Lisanti MP
    Cancer Biol Ther; 2011 Dec; 12(12):1101-13. PubMed ID: 22236875
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.
    Martinez-Outschoorn U; Sotgia F; Lisanti MP
    Semin Oncol; 2014 Apr; 41(2):195-216. PubMed ID: 24787293
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
    Balliet RM; Capparelli C; Guido C; Pestell TG; Martinez-Outschoorn UE; Lin Z; Whitaker-Menezes D; Chiavarina B; Pestell RG; Howell A; Sotgia F; Lisanti MP
    Cell Cycle; 2011 Dec; 10(23):4065-73. PubMed ID: 22129993
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.
    Castello-Cros R; Bonuccelli G; Molchansky A; Capozza F; Witkiewicz AK; Birbe RC; Howell A; Pestell RG; Whitaker-Menezes D; Sotgia F; Lisanti MP
    Cell Cycle; 2011 Jun; 10(12):2021-34. PubMed ID: 21646868
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts.
    Trimmer C; Sotgia F; Whitaker-Menezes D; Balliet RM; Eaton G; Martinez-Outschoorn UE; Pavlides S; Howell A; Iozzo RV; Pestell RG; Scherer PE; Capozza F; Lisanti MP
    Cancer Biol Ther; 2011 Feb; 11(4):383-94. PubMed ID: 21150282
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
    Migneco G; Whitaker-Menezes D; Chiavarina B; Castello-Cros R; Pavlides S; Pestell RG; Fatatis A; Flomenberg N; Tsirigos A; Howell A; Martinez-Outschoorn UE; Sotgia F; Lisanti MP
    Cell Cycle; 2010 Jun; 9(12):2412-22. PubMed ID: 20562527
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.
    Martinez-Outschoorn UE; Pavlides S; Whitaker-Menezes D; Daumer KM; Milliman JN; Chiavarina B; Migneco G; Witkiewicz AK; Martinez-Cantarin MP; Flomenberg N; Howell A; Pestell RG; Lisanti MP; Sotgia F
    Cell Cycle; 2010 Jun; 9(12):2423-33. PubMed ID: 20562526
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
    Chiavarina B; Martinez-Outschoorn UE; Whitaker-Menezes D; Howell A; Tanowitz HB; Pestell RG; Sotgia F; Lisanti MP
    Cell Cycle; 2012 Sep; 11(17):3280-9. PubMed ID: 22894905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
    Martinez-Outschoorn UE; Balliet RM; Rivadeneira DB; Chiavarina B; Pavlides S; Wang C; Whitaker-Menezes D; Daumer KM; Lin Z; Witkiewicz AK; Flomenberg N; Howell A; Pestell RG; Knudsen ES; Sotgia F; Lisanti MP
    Cell Cycle; 2010 Aug; 9(16):3256-76. PubMed ID: 20814239
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
    Martinez-Outschoorn UE; Balliet R; Lin Z; Whitaker-Menezes D; Birbe RC; Bombonati A; Pavlides S; Lamb R; Sneddon S; Howell A; Sotgia F; Lisanti MP
    Cell Cycle; 2012 Dec; 11(23):4402-13. PubMed ID: 23172369
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.
    Pavlides S; Tsirigos A; Vera I; Flomenberg N; Frank PG; Casimiro MC; Wang C; Fortina P; Addya S; Pestell RG; Martinez-Outschoorn UE; Sotgia F; Lisanti MP
    Cell Cycle; 2010 Jun; 9(11):2201-19. PubMed ID: 20519932
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
    Bonuccelli G; Whitaker-Menezes D; Castello-Cros R; Pavlides S; Pestell RG; Fatatis A; Witkiewicz AK; Vander Heiden MG; Migneco G; Chiavarina B; Frank PG; Capozza F; Flomenberg N; Martinez-Outschoorn UE; Sotgia F; Lisanti MP
    Cell Cycle; 2010 May; 9(10):1960-71. PubMed ID: 20495363
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo.
    Al-Zoubi M; Salem AF; Martinez-Outschoorn UE; Whitaker-Menezes D; Lamb R; Hulit J; Howell A; Gandara R; Sartini M; Arafat H; Bevilacqua G; Sotgia F; Lisanti MP
    Cell Cycle; 2013 Feb; 12(3):480-90. PubMed ID: 23292149
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.
    Capparelli C; Guido C; Whitaker-Menezes D; Bonuccelli G; Balliet R; Pestell TG; Goldberg AF; Pestell RG; Howell A; Sneddon S; Birbe R; Tsirigos A; Martinez-Outschoorn U; Sotgia F; Lisanti MP
    Cell Cycle; 2012 Jun; 11(12):2285-302. PubMed ID: 22684298
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
    Pavlides S; Tsirigos A; Migneco G; Whitaker-Menezes D; Chiavarina B; Flomenberg N; Frank PG; Casimiro MC; Wang C; Pestell RG; Martinez-Outschoorn UE; Howell A; Sotgia F; Lisanti MP
    Cell Cycle; 2010 Sep; 9(17):3485-505. PubMed ID: 20861672
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.