BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

193 related articles for article (PubMed ID: 22685215)

  • 1. Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
    Amunugama HT; Zhang H; Hollenberg PF
    Drug Metab Dispos; 2012 Sep; 40(9):1765-70. PubMed ID: 22685215
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
    Lin HL; Zhang H; Hollenberg PF
    J Pharmacol Exp Ther; 2009 Apr; 329(1):26-37. PubMed ID: 19168709
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL; Kent UM; Hollenberg PF
    J Pharmacol Exp Ther; 2005 Apr; 313(1):154-64. PubMed ID: 15608076
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
    Zhang H; Amunugama H; Ney S; Cooper N; Hollenberg PF
    Mol Pharmacol; 2011 Nov; 80(5):839-47. PubMed ID: 21862689
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts.
    Sridar C; Kenaan C; Hollenberg PF
    Drug Metab Dispos; 2012 Dec; 40(12):2256-66. PubMed ID: 22936314
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI; Kent UM; Hollenberg PF
    Drug Metab Dispos; 2003 Jan; 31(1):46-52. PubMed ID: 12485952
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
    Harleton E; Webster M; Bumpus NN; Kent UM; Rae JM; Hollenberg PF
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1011-9. PubMed ID: 15121764
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.
    Gerber JG; Rhodes RJ; Gal J
    Chirality; 2004 Jan; 16(1):36-44. PubMed ID: 14628297
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor.
    Fan PW; Gu C; Marsh SA; Stevens JC
    Drug Metab Dispos; 2003 Jan; 31(1):28-36. PubMed ID: 12485950
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation.
    Chang Y; Fang WB; Lin SN; Moody DE
    Basic Clin Pharmacol Toxicol; 2011 Jan; 108(1):55-62. PubMed ID: 20825389
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene.
    Lin HL; Zhang H; Pratt-Hyatt MJ; Hollenberg PF
    Drug Metab Dispos; 2011 Dec; 39(12):2431-9. PubMed ID: 21930824
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir.
    Lin HL; D'Agostino J; Kenaan C; Calinski D; Hollenberg PF
    Drug Metab Dispos; 2013 Oct; 41(10):1813-24. PubMed ID: 23886699
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.
    Shebley M; Kent UM; Ballou DP; Hollenberg PF
    Drug Metab Dispos; 2009 Apr; 37(4):745-52. PubMed ID: 19144770
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.
    Sridar C; Kent UM; Notley LM; Gillam EM; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Jun; 301(3):945-52. PubMed ID: 12023523
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4.
    Casabar RC; Wallace AD; Hodgson E; Rose RL
    Drug Metab Dispos; 2006 Oct; 34(10):1779-85. PubMed ID: 16855053
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.
    Kent UM; Aviram M; Rosenblat M; Hollenberg PF
    Drug Metab Dispos; 2002 Jun; 30(6):709-15. PubMed ID: 12019199
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of cytochrome P4502B6 in methadone metabolism and clearance.
    Kharasch ED; Stubbert K
    J Clin Pharmacol; 2013 Mar; 53(3):305-13. PubMed ID: 23361846
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
    Chun J; Kent UM; Moss RM; Sayre LM; Hollenberg PF
    Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
    Blobaum AL; Kent UM; Alworth WL; Hollenberg PF
    Chem Res Toxicol; 2002 Dec; 15(12):1561-71. PubMed ID: 12482238
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM; Mills DE; Rajnarayanan RV; Alworth WL; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.