288 related articles for article (PubMed ID: 22699492)
1. A single ligand is sufficient to activate EGFR dimers.
Liu P; Cleveland TE; Bouyain S; Byrne PO; Longo PA; Leahy DJ
Proc Natl Acad Sci U S A; 2012 Jul; 109(27):10861-6. PubMed ID: 22699492
[TBL] [Abstract][Full Text] [Related]
2. ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.
Alvarado D; Klein DE; Lemmon MA
Nature; 2009 Sep; 461(7261):287-91. PubMed ID: 19718021
[TBL] [Abstract][Full Text] [Related]
3. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.
Bouyain S; Longo PA; Li S; Ferguson KM; Leahy DJ
Proc Natl Acad Sci U S A; 2005 Oct; 102(42):15024-9. PubMed ID: 16203964
[TBL] [Abstract][Full Text] [Related]
4. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.
Garrett TP; McKern NM; Lou M; Elleman TC; Adams TE; Lovrecz GO; Kofler M; Jorissen RN; Nice EC; Burgess AW; Ward CW
Mol Cell; 2003 Feb; 11(2):495-505. PubMed ID: 12620236
[TBL] [Abstract][Full Text] [Related]
5. Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.
Monsey J; Shen W; Schlesinger P; Bose R
J Biol Chem; 2010 Mar; 285(10):7035-44. PubMed ID: 20022944
[TBL] [Abstract][Full Text] [Related]
6. Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family.
Arkhipov A; Shan Y; Kim ET; Dror RO; Shaw DE
Elife; 2013 Jul; 2():e00708. PubMed ID: 23878723
[TBL] [Abstract][Full Text] [Related]
7. Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.
Ward MD; Leahy DJ
J Biol Chem; 2015 Jan; 290(3):1570-9. PubMed ID: 25468910
[TBL] [Abstract][Full Text] [Related]
8. Structural basis for negative cooperativity in growth factor binding to an EGF receptor.
Alvarado D; Klein DE; Lemmon MA
Cell; 2010 Aug; 142(4):568-79. PubMed ID: 20723758
[TBL] [Abstract][Full Text] [Related]
9. A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion.
Fichter CD; Przypadlo CM; Buck A; Herbener N; Riedel B; Schäfer L; Nakagawa H; Walch A; Reinheckel T; Werner M; Lassmann S
J Pathol; 2017 Dec; 243(4):481-495. PubMed ID: 28940194
[TBL] [Abstract][Full Text] [Related]
10. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
Li Y; Macdonald-Obermann J; Westfall C; Piwnica-Worms D; Pike LJ
J Biol Chem; 2012 Sep; 287(37):31116-25. PubMed ID: 22822073
[TBL] [Abstract][Full Text] [Related]
11. ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells.
Choi BK; Fan X; Deng H; Zhang N; An Z
Cancer Med; 2012 Aug; 1(1):28-38. PubMed ID: 23342251
[TBL] [Abstract][Full Text] [Related]
12. Structural basis for EGFR ligand sequestration by Argos.
Klein DE; Stayrook SE; Shi F; Narayan K; Lemmon MA
Nature; 2008 Jun; 453(7199):1271-5. PubMed ID: 18500331
[TBL] [Abstract][Full Text] [Related]
13. Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
Macdonald-Obermann JL; Pike LJ
J Biol Chem; 2014 Sep; 289(38):26178-26188. PubMed ID: 25086039
[TBL] [Abstract][Full Text] [Related]
14. ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation.
Feroz K; Williams E; Riese DJ
Cell Signal; 2002 Sep; 14(9):793-8. PubMed ID: 12034361
[TBL] [Abstract][Full Text] [Related]
15. The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.
Liu P; Bouyain S; Eigenbrot C; Leahy DJ
Protein Sci; 2012 Jan; 21(1):152-5. PubMed ID: 22012915
[TBL] [Abstract][Full Text] [Related]
16. Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging.
Macdonald-Obermann JL; Piwnica-Worms D; Pike LJ
Proc Natl Acad Sci U S A; 2012 Jan; 109(1):137-42. PubMed ID: 22190492
[TBL] [Abstract][Full Text] [Related]
17. Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.
Tynan CJ; Roberts SK; Rolfe DJ; Clarke DT; Loeffler HH; Kästner J; Winn MD; Parker PJ; Martin-Fernandez ML
Mol Cell Biol; 2011 Jun; 31(11):2241-52. PubMed ID: 21444717
[TBL] [Abstract][Full Text] [Related]
18. Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis.
Clayton AH; Walker F; Orchard SG; Henderson C; Fuchs D; Rothacker J; Nice EC; Burgess AW
J Biol Chem; 2005 Aug; 280(34):30392-9. PubMed ID: 15994331
[TBL] [Abstract][Full Text] [Related]
19. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
Aertgeerts K; Skene R; Yano J; Sang BC; Zou H; Snell G; Jennings A; Iwamoto K; Habuka N; Hirokawa A; Ishikawa T; Tanaka T; Miki H; Ohta Y; Sogabe S
J Biol Chem; 2011 May; 286(21):18756-65. PubMed ID: 21454582
[TBL] [Abstract][Full Text] [Related]
20. Ligand discrimination in signaling through an ErbB4 receptor homodimer.
Sweeney C; Lai C; Riese DJ; Diamonti AJ; Cantley LC; Carraway KL
J Biol Chem; 2000 Jun; 275(26):19803-7. PubMed ID: 10867024
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]