263 related articles for article (PubMed ID: 22702834)
1. In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2.
London N; Gullá S; Keating AE; Schueler-Furman O
Biochemistry; 2012 Jul; 51(29):5841-50. PubMed ID: 22702834
[TBL] [Abstract][Full Text] [Related]
2. Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
Dutta S; Gullá S; Chen TS; Fire E; Grant RA; Keating AE
J Mol Biol; 2010 May; 398(5):747-62. PubMed ID: 20363230
[TBL] [Abstract][Full Text] [Related]
3. Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.
Boersma MD; Haase HS; Peterson-Kaufman KJ; Lee EF; Clarke OB; Colman PM; Smith BJ; Horne WS; Fairlie WD; Gellman SH
J Am Chem Soc; 2012 Jan; 134(1):315-23. PubMed ID: 22040025
[TBL] [Abstract][Full Text] [Related]
4. A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
Lee EF; Czabotar PE; van Delft MF; Michalak EM; Boyle MJ; Willis SN; Puthalakath H; Bouillet P; Colman PM; Huang DC; Fairlie WD
J Cell Biol; 2008 Jan; 180(2):341-55. PubMed ID: 18209102
[TBL] [Abstract][Full Text] [Related]
5. Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Rajan S; Choi M; Baek K; Yoon HS
Proteins; 2015 Jul; 83(7):1262-72. PubMed ID: 25907960
[TBL] [Abstract][Full Text] [Related]
6. Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
Foight GW; Ryan JA; Gullá SV; Letai A; Keating AE
ACS Chem Biol; 2014 Sep; 9(9):1962-8. PubMed ID: 25052212
[TBL] [Abstract][Full Text] [Related]
7. Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot spot interactions.
Moroy G; Martin E; Dejaegere A; Stote RH
J Biol Chem; 2009 Jun; 284(26):17499-511. PubMed ID: 19293158
[TBL] [Abstract][Full Text] [Related]
8. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
Kazi A; Sun J; Doi K; Sung SS; Takahashi Y; Yin H; Rodriguez JM; Becerril J; Berndt N; Hamilton AD; Wang HG; Sebti SM
J Biol Chem; 2011 Mar; 286(11):9382-92. PubMed ID: 21148306
[TBL] [Abstract][Full Text] [Related]
9. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
Du H; Wolf J; Schafer B; Moldoveanu T; Chipuk JE; Kuwana T
J Biol Chem; 2011 Jan; 286(1):491-501. PubMed ID: 21041309
[TBL] [Abstract][Full Text] [Related]
10. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Chen L; Willis SN; Wei A; Smith BJ; Fletcher JI; Hinds MG; Colman PM; Day CL; Adams JM; Huang DC
Mol Cell; 2005 Feb; 17(3):393-403. PubMed ID: 15694340
[TBL] [Abstract][Full Text] [Related]
11. Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides.
Modi V; Sankararamakrishnan R
J Mol Graph Model; 2017 May; 73():115-128. PubMed ID: 28279820
[TBL] [Abstract][Full Text] [Related]
12. Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.
Lama D; Sankararamakrishnan R
Proteins; 2008 Nov; 73(2):492-514. PubMed ID: 18452209
[TBL] [Abstract][Full Text] [Related]
13. Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).
Chen TS; Palacios H; Keating AE
J Mol Biol; 2013 Jan; 425(1):171-85. PubMed ID: 23154169
[TBL] [Abstract][Full Text] [Related]
14. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
Kuwana T; Bouchier-Hayes L; Chipuk JE; Bonzon C; Sullivan BA; Green DR; Newmeyer DD
Mol Cell; 2005 Feb; 17(4):525-35. PubMed ID: 15721256
[TBL] [Abstract][Full Text] [Related]
15. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Fire E; Gullá SV; Grant RA; Keating AE
Protein Sci; 2010 Mar; 19(3):507-19. PubMed ID: 20066663
[TBL] [Abstract][Full Text] [Related]
16. Molecular dynamics study of segment peptides of Bax, Bim, and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein.
Zhao RN; Fan S; Han JG; Liu G
J Biomol Struct Dyn; 2015; 33(5):1067-81. PubMed ID: 24865469
[TBL] [Abstract][Full Text] [Related]
17. Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.
Lee MS; Ha JH; Yoon HS; Lee CK; Chi SW
Biochem Biophys Res Commun; 2014 Feb; 445(1):120-5. PubMed ID: 24491548
[TBL] [Abstract][Full Text] [Related]
18. A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity.
Ponassi R; Biasotti B; Tomati V; Bruno S; Poggi A; Malacarne D; Cimoli G; Salis A; Pozzi S; Miglino M; Damonte G; Cozzini P; Spyrakis F; Campanini B; Bagnasco L; Castagnino N; Tortolina L; Mumot A; Frassoni F; Daga A; Cilli M; Piccardi F; Monfardini I; Perugini M; Zoppoli G; D'Arrigo C; Pesenti R; Parodi S
Cell Cycle; 2008 Oct; 7(20):3211-24. PubMed ID: 18843207
[TBL] [Abstract][Full Text] [Related]
19. CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
Chen S; Dai Y; Pei XY; Myers J; Wang L; Kramer LB; Garnett M; Schwartz DM; Su F; Simmons GL; Richey JD; Larsen DG; Dent P; Orlowski RZ; Grant S
Cancer Res; 2012 Aug; 72(16):4225-37. PubMed ID: 22693249
[TBL] [Abstract][Full Text] [Related]
20. Molecular dynamics simulations of pro-apoptotic BH3 peptide helices in aqueous medium: relationship between helix stability and their binding affinities to the anti-apoptotic protein Bcl-X(L).
Lama D; Sankararamakrishnan R
J Comput Aided Mol Des; 2011 May; 25(5):413-26. PubMed ID: 21523491
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]